Unusual pattern of chikungunya virus epidemic in the Americas, the Panamanian experience.
BACKGROUND:Chikungunya virus (CHIKV) typically causes explosive epidemics of fever, rash and polyarthralgia after its introduction into naïve populations. Since its introduction in Panama in May of 2014, few autochthonous cases have been reported; most of them were found within limited outbreaks in...
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ftdoajarticles:oai:doaj.org/article:27f6adfeb83b4da997bc60494106265c 2023-05-15T15:16:40+02:00 Unusual pattern of chikungunya virus epidemic in the Americas, the Panamanian experience. Jean-Paul Carrera Yamilka Díaz Bernardino Denis Itza Barahona de Mosca Dennys Rodriguez Israel Cedeño Dimelza Arauz Publio González Lizbeth Cerezo Lourdes Moreno Lourdes García Lisseth E Sáenz María Aneth Atencio Eddy Rojas-Fermin Fernando Vizcaino Nicolas Perez Brechla Moreno Sandra López-Vergès Anayansi Valderrama Blas Armién 2017-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005338 https://doaj.org/article/27f6adfeb83b4da997bc60494106265c EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5336303?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005338 https://doaj.org/article/27f6adfeb83b4da997bc60494106265c PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005338 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005338 2022-12-31T04:48:53Z BACKGROUND:Chikungunya virus (CHIKV) typically causes explosive epidemics of fever, rash and polyarthralgia after its introduction into naïve populations. Since its introduction in Panama in May of 2014, few autochthonous cases have been reported; most of them were found within limited outbreaks in Panama City in 2014 and Puerto Obaldia town, near the Caribbean border with Colombia in 2015. In order to confirm that Panama had few CHIKV cases compared with neighboring countries, we perform an epidemiological analysis of chikungunya cases reported from May 2014 to July 2015. Moreover, to understand this paucity of confirmed CHIKV cases, a vectorial analysis in the counties where these cases were reported was performed. METHODS:Chikungunya cases were identified at medical centers and notified to health authorities. Sera samples were analyzed at Gorgas Memorial Institute for viral RNA and CHIKV-specific antibody detection. RESULTS:A total of 413 suspected cases of CHIKV infections were reported, with incidence rates of 0.5 and 0.7 per 100,000 inhabitants in 2014 and 2015, respectively. During this period, 38.6% of CHIKV cases were autochthonous with rash and polyarthralgia as predominant symptoms. CHIKV and DENV incidence ratios were 1:306 and 1:34, respectively. A phylogenetic analysis of E1/E2 genomic segment indicates that the outbreak strains belong to the Asian genotype and cluster together with CHIKV isolates from other American countries during the same period. Statistical analysis of the National Vector Control program at the district level shows low and medium vector infestation level for most of the counties with CHIKV cases. This index was lower than for neighboring countries. CONCLUSIONS:Previous training of clinical, laboratory and vector workers allowed a good caption and detection of the chikungunya cases and fast intervention. It is possible that low/medium vector infestation level could explain in part the paucity of chikungunya infections in Panama. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 2 e0005338 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jean-Paul Carrera Yamilka Díaz Bernardino Denis Itza Barahona de Mosca Dennys Rodriguez Israel Cedeño Dimelza Arauz Publio González Lizbeth Cerezo Lourdes Moreno Lourdes García Lisseth E Sáenz María Aneth Atencio Eddy Rojas-Fermin Fernando Vizcaino Nicolas Perez Brechla Moreno Sandra López-Vergès Anayansi Valderrama Blas Armién Unusual pattern of chikungunya virus epidemic in the Americas, the Panamanian experience. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Chikungunya virus (CHIKV) typically causes explosive epidemics of fever, rash and polyarthralgia after its introduction into naïve populations. Since its introduction in Panama in May of 2014, few autochthonous cases have been reported; most of them were found within limited outbreaks in Panama City in 2014 and Puerto Obaldia town, near the Caribbean border with Colombia in 2015. In order to confirm that Panama had few CHIKV cases compared with neighboring countries, we perform an epidemiological analysis of chikungunya cases reported from May 2014 to July 2015. Moreover, to understand this paucity of confirmed CHIKV cases, a vectorial analysis in the counties where these cases were reported was performed. METHODS:Chikungunya cases were identified at medical centers and notified to health authorities. Sera samples were analyzed at Gorgas Memorial Institute for viral RNA and CHIKV-specific antibody detection. RESULTS:A total of 413 suspected cases of CHIKV infections were reported, with incidence rates of 0.5 and 0.7 per 100,000 inhabitants in 2014 and 2015, respectively. During this period, 38.6% of CHIKV cases were autochthonous with rash and polyarthralgia as predominant symptoms. CHIKV and DENV incidence ratios were 1:306 and 1:34, respectively. A phylogenetic analysis of E1/E2 genomic segment indicates that the outbreak strains belong to the Asian genotype and cluster together with CHIKV isolates from other American countries during the same period. Statistical analysis of the National Vector Control program at the district level shows low and medium vector infestation level for most of the counties with CHIKV cases. This index was lower than for neighboring countries. CONCLUSIONS:Previous training of clinical, laboratory and vector workers allowed a good caption and detection of the chikungunya cases and fast intervention. It is possible that low/medium vector infestation level could explain in part the paucity of chikungunya infections in Panama. |
format |
Article in Journal/Newspaper |
author |
Jean-Paul Carrera Yamilka Díaz Bernardino Denis Itza Barahona de Mosca Dennys Rodriguez Israel Cedeño Dimelza Arauz Publio González Lizbeth Cerezo Lourdes Moreno Lourdes García Lisseth E Sáenz María Aneth Atencio Eddy Rojas-Fermin Fernando Vizcaino Nicolas Perez Brechla Moreno Sandra López-Vergès Anayansi Valderrama Blas Armién |
author_facet |
Jean-Paul Carrera Yamilka Díaz Bernardino Denis Itza Barahona de Mosca Dennys Rodriguez Israel Cedeño Dimelza Arauz Publio González Lizbeth Cerezo Lourdes Moreno Lourdes García Lisseth E Sáenz María Aneth Atencio Eddy Rojas-Fermin Fernando Vizcaino Nicolas Perez Brechla Moreno Sandra López-Vergès Anayansi Valderrama Blas Armién |
author_sort |
Jean-Paul Carrera |
title |
Unusual pattern of chikungunya virus epidemic in the Americas, the Panamanian experience. |
title_short |
Unusual pattern of chikungunya virus epidemic in the Americas, the Panamanian experience. |
title_full |
Unusual pattern of chikungunya virus epidemic in the Americas, the Panamanian experience. |
title_fullStr |
Unusual pattern of chikungunya virus epidemic in the Americas, the Panamanian experience. |
title_full_unstemmed |
Unusual pattern of chikungunya virus epidemic in the Americas, the Panamanian experience. |
title_sort |
unusual pattern of chikungunya virus epidemic in the americas, the panamanian experience. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005338 https://doaj.org/article/27f6adfeb83b4da997bc60494106265c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005338 (2017) |
op_relation |
http://europepmc.org/articles/PMC5336303?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005338 https://doaj.org/article/27f6adfeb83b4da997bc60494106265c |
op_doi |
https://doi.org/10.1371/journal.pntd.0005338 |
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PLOS Neglected Tropical Diseases |
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11 |
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2 |
container_start_page |
e0005338 |
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1766346970982514688 |