Efficacy of low-dose myrrh protocols in the treatment of experimental schistosomiasis mansoni: hepatic improvement without parasitologic cure
Rashad Abdul-Ghani1, Naguiba Loutfy2, Manal Sheta3, Azza Hassan21Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen; 2Tropical Health Department, High Institute of Public Health, 3Department of Pathology, Medical Research Institute, Alexandr...
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ftdoajarticles:oai:doaj.org/article:27c84a58608b4d7aa3efc0dc7b83199d 2023-05-15T15:09:24+02:00 Efficacy of low-dose myrrh protocols in the treatment of experimental schistosomiasis mansoni: hepatic improvement without parasitologic cure Rashad Abdul-Ghani Naguiba Loutfy Manal Sheta 2010-11-01T00:00:00Z https://doaj.org/article/27c84a58608b4d7aa3efc0dc7b83199d EN eng Dove Medical Press http://www.dovepress.com/efficacy-of-low-dose-myrrh-protocols-in-the-treatment-of-experimental--a5675 https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/27c84a58608b4d7aa3efc0dc7b83199d Research and Reports in Tropical Medicine, Vol 2010, Iss default, Pp 65-71 (2010) Arctic medicine. Tropical medicine RC955-962 article 2010 ftdoajarticles 2022-12-31T04:55:03Z Rashad Abdul-Ghani1, Naguiba Loutfy2, Manal Sheta3, Azza Hassan21Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen; 2Tropical Health Department, High Institute of Public Health, 3Department of Pathology, Medical Research Institute, Alexandria University, Alexandria, EgyptAbstract: There is a new trend of “back to nature” in searching for antischistosomal drugs, particularly after the concerns raised about the possible emergence of schistosome isolates resistant/tolerant to praziquantel as well as for their relative safety and fewer side effects. Many plant derivatives have been investigated for efficacy against the Egyptian strain of Schistosoma mansoni, but much attention has been paid to myrrh extract, which is a purified sap obtained from Commiphora molmol. This extract has been produced and marketed in Egypt as a pharmaceutical preparation, but with a great discrepancy in its antischistosomal activity in both experimental and clinical studies. Most previous experimental studies used myrrh in the dosing protocol of 500 mg/kg/day for five days. In the present study, we investigated the therapeutic efficacy of three low-dose myrrh protocols against experimental schistosomiasis mansoni. All these protocols showed no significant efficacy in reducing parasite burdens and tissue egg loads or in changing oogram patterns. Nevertheless, there was an amelioration of hepatic lesions, with reductions in mean counts of hepatic granulomas as well as marked healing of these granulomas.Keywords: Schistosoma mansoni, schistosomiasis mansoni, myrrh, Commiphora molmol, antischistosomal chemotherapy Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Rashad Abdul-Ghani Naguiba Loutfy Manal Sheta Efficacy of low-dose myrrh protocols in the treatment of experimental schistosomiasis mansoni: hepatic improvement without parasitologic cure |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Rashad Abdul-Ghani1, Naguiba Loutfy2, Manal Sheta3, Azza Hassan21Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen; 2Tropical Health Department, High Institute of Public Health, 3Department of Pathology, Medical Research Institute, Alexandria University, Alexandria, EgyptAbstract: There is a new trend of “back to nature” in searching for antischistosomal drugs, particularly after the concerns raised about the possible emergence of schistosome isolates resistant/tolerant to praziquantel as well as for their relative safety and fewer side effects. Many plant derivatives have been investigated for efficacy against the Egyptian strain of Schistosoma mansoni, but much attention has been paid to myrrh extract, which is a purified sap obtained from Commiphora molmol. This extract has been produced and marketed in Egypt as a pharmaceutical preparation, but with a great discrepancy in its antischistosomal activity in both experimental and clinical studies. Most previous experimental studies used myrrh in the dosing protocol of 500 mg/kg/day for five days. In the present study, we investigated the therapeutic efficacy of three low-dose myrrh protocols against experimental schistosomiasis mansoni. All these protocols showed no significant efficacy in reducing parasite burdens and tissue egg loads or in changing oogram patterns. Nevertheless, there was an amelioration of hepatic lesions, with reductions in mean counts of hepatic granulomas as well as marked healing of these granulomas.Keywords: Schistosoma mansoni, schistosomiasis mansoni, myrrh, Commiphora molmol, antischistosomal chemotherapy |
format |
Article in Journal/Newspaper |
author |
Rashad Abdul-Ghani Naguiba Loutfy Manal Sheta |
author_facet |
Rashad Abdul-Ghani Naguiba Loutfy Manal Sheta |
author_sort |
Rashad Abdul-Ghani |
title |
Efficacy of low-dose myrrh protocols in the treatment of experimental schistosomiasis mansoni: hepatic improvement without parasitologic cure |
title_short |
Efficacy of low-dose myrrh protocols in the treatment of experimental schistosomiasis mansoni: hepatic improvement without parasitologic cure |
title_full |
Efficacy of low-dose myrrh protocols in the treatment of experimental schistosomiasis mansoni: hepatic improvement without parasitologic cure |
title_fullStr |
Efficacy of low-dose myrrh protocols in the treatment of experimental schistosomiasis mansoni: hepatic improvement without parasitologic cure |
title_full_unstemmed |
Efficacy of low-dose myrrh protocols in the treatment of experimental schistosomiasis mansoni: hepatic improvement without parasitologic cure |
title_sort |
efficacy of low-dose myrrh protocols in the treatment of experimental schistosomiasis mansoni: hepatic improvement without parasitologic cure |
publisher |
Dove Medical Press |
publishDate |
2010 |
url |
https://doaj.org/article/27c84a58608b4d7aa3efc0dc7b83199d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Research and Reports in Tropical Medicine, Vol 2010, Iss default, Pp 65-71 (2010) |
op_relation |
http://www.dovepress.com/efficacy-of-low-dose-myrrh-protocols-in-the-treatment-of-experimental--a5675 https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/27c84a58608b4d7aa3efc0dc7b83199d |
_version_ |
1766340600975589376 |