Optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology
Abstract Background Developing an efficient lipophilization reaction system for phenolic derivatives could enhance their applications in food processing. Low solubility of phenolic acids reduces the efficiency of phenolic derivatives in most benign enzyme solvents. The conversion of phenolic acids t...
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ftdoajarticles:oai:doaj.org/article:27b9ff303a924bf3ab738934a455820b 2023-05-15T14:15:37+02:00 Optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology Somayeh Gholivand Ola Lasekan Chin Ping Tan Faridah Abas Leong Sze Wei 2017-05-01T00:00:00Z https://doi.org/10.1186/s13065-017-0276-2 https://doaj.org/article/27b9ff303a924bf3ab738934a455820b EN eng BMC http://link.springer.com/article/10.1186/s13065-017-0276-2 https://doaj.org/toc/1752-153X doi:10.1186/s13065-017-0276-2 1752-153X https://doaj.org/article/27b9ff303a924bf3ab738934a455820b Chemistry Central Journal, Vol 11, Iss 1, Pp 1-10 (2017) Enzymatic esterification Hexyl dihydrocaffeate Candida antartica lipase (Novozyme 435) Ionic liquid Response surface methodology (RSM) Chemistry QD1-999 article 2017 ftdoajarticles https://doi.org/10.1186/s13065-017-0276-2 2022-12-31T07:59:52Z Abstract Background Developing an efficient lipophilization reaction system for phenolic derivatives could enhance their applications in food processing. Low solubility of phenolic acids reduces the efficiency of phenolic derivatives in most benign enzyme solvents. The conversion of phenolic acids through esterification alters their solubility and enhances their use as food antioxidant additives as well as their application in cosmetics. Results This study has shown that lipase-catalyzed esterification of dihydrocaffeic acid with hexanol in ionic liquid (1-butyl-3-methylimidazoliumbis (trifluoromethylsulfonyl) imide) was the best approach for esterification reaction. In order to achieve the maximum yield, the process was optimized by response surface methodology (RSM) based on a five-level and four independent variables such as: dosage of enzyme; hexanol/dihydrocaffeic acid mole ratio; temperature and reaction time. The optimum esterification condition (Y = 84.4%) was predicted to be obtained at temperature of 39.4 °C, time of 77.5 h dosage of enzyme at 41.6% and hexanol/dihydrocaffeic acid mole ratio of 2.1. Conclusion Finally, this study has produced an efficient enzymatic esterification method for the preparation of hexyl dihydrocaffeate in vitro using a lipase in an ionic liquid system. Concentration of hexanol was the most significant (p < 0.05) independent variable that influenced the yield of hexyl dihydrocaffeate. Graphical abstract Synthesis of different Hexyl dihydrocaffeates in ionic liquid Article in Journal/Newspaper antartic* Directory of Open Access Journals: DOAJ Articles Chemistry Central Journal 11 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Enzymatic esterification Hexyl dihydrocaffeate Candida antartica lipase (Novozyme 435) Ionic liquid Response surface methodology (RSM) Chemistry QD1-999 |
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Enzymatic esterification Hexyl dihydrocaffeate Candida antartica lipase (Novozyme 435) Ionic liquid Response surface methodology (RSM) Chemistry QD1-999 Somayeh Gholivand Ola Lasekan Chin Ping Tan Faridah Abas Leong Sze Wei Optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology |
topic_facet |
Enzymatic esterification Hexyl dihydrocaffeate Candida antartica lipase (Novozyme 435) Ionic liquid Response surface methodology (RSM) Chemistry QD1-999 |
description |
Abstract Background Developing an efficient lipophilization reaction system for phenolic derivatives could enhance their applications in food processing. Low solubility of phenolic acids reduces the efficiency of phenolic derivatives in most benign enzyme solvents. The conversion of phenolic acids through esterification alters their solubility and enhances their use as food antioxidant additives as well as their application in cosmetics. Results This study has shown that lipase-catalyzed esterification of dihydrocaffeic acid with hexanol in ionic liquid (1-butyl-3-methylimidazoliumbis (trifluoromethylsulfonyl) imide) was the best approach for esterification reaction. In order to achieve the maximum yield, the process was optimized by response surface methodology (RSM) based on a five-level and four independent variables such as: dosage of enzyme; hexanol/dihydrocaffeic acid mole ratio; temperature and reaction time. The optimum esterification condition (Y = 84.4%) was predicted to be obtained at temperature of 39.4 °C, time of 77.5 h dosage of enzyme at 41.6% and hexanol/dihydrocaffeic acid mole ratio of 2.1. Conclusion Finally, this study has produced an efficient enzymatic esterification method for the preparation of hexyl dihydrocaffeate in vitro using a lipase in an ionic liquid system. Concentration of hexanol was the most significant (p < 0.05) independent variable that influenced the yield of hexyl dihydrocaffeate. Graphical abstract Synthesis of different Hexyl dihydrocaffeates in ionic liquid |
format |
Article in Journal/Newspaper |
author |
Somayeh Gholivand Ola Lasekan Chin Ping Tan Faridah Abas Leong Sze Wei |
author_facet |
Somayeh Gholivand Ola Lasekan Chin Ping Tan Faridah Abas Leong Sze Wei |
author_sort |
Somayeh Gholivand |
title |
Optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology |
title_short |
Optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology |
title_full |
Optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology |
title_fullStr |
Optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology |
title_full_unstemmed |
Optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology |
title_sort |
optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology |
publisher |
BMC |
publishDate |
2017 |
url |
https://doi.org/10.1186/s13065-017-0276-2 https://doaj.org/article/27b9ff303a924bf3ab738934a455820b |
genre |
antartic* |
genre_facet |
antartic* |
op_source |
Chemistry Central Journal, Vol 11, Iss 1, Pp 1-10 (2017) |
op_relation |
http://link.springer.com/article/10.1186/s13065-017-0276-2 https://doaj.org/toc/1752-153X doi:10.1186/s13065-017-0276-2 1752-153X https://doaj.org/article/27b9ff303a924bf3ab738934a455820b |
op_doi |
https://doi.org/10.1186/s13065-017-0276-2 |
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Chemistry Central Journal |
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11 |
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1 |
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