A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis.
BACKGROUND:Infection of bones and joints remains one of the most commonly described complications of brucellosis in humans and is predominantly reported in all ages and sexes in high-risk regions, such as the Middle East, Asia, South and Central America, and Africa. We aimed to systematically review...
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ftdoajarticles:oai:doaj.org/article:27a6d2982c384a5789d4e580ca5e5ed7 2023-05-15T15:10:08+02:00 A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. Shakirat A Adetunji Gilbert Ramirez Margaret J Foster Angela M Arenas-Gamboa 2019-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007112 https://doaj.org/article/27a6d2982c384a5789d4e580ca5e5ed7 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6355028?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007112 https://doaj.org/article/27a6d2982c384a5789d4e580ca5e5ed7 PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0007112 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007112 2022-12-31T01:42:03Z BACKGROUND:Infection of bones and joints remains one of the most commonly described complications of brucellosis in humans and is predominantly reported in all ages and sexes in high-risk regions, such as the Middle East, Asia, South and Central America, and Africa. We aimed to systematically review the literature and perform a meta-analysis to estimate the global prevalence of osteoarticular brucellosis (OAB). METHODOLOGY:Major bibliographic databases were searched using keywords and suitable combinations. All studies reporting the incidence and clinical manifestations of osteoarticular brucellosis in humans, and demonstrated by two or more diagnostic methods (bacteriological, molecular, serological, and/or radiographic) were included. Random model was used, and statistical significance was set at 0.05. PRINCIPAL FINDINGS:A total of 56 studies met the inclusion criteria and were included in the systematic review and meta-analysis. There was an evidence of geographical variation in the prevalence of osteoarticular disease with estimates ranging from 27% in low-risk regions to 36% in high-risk regions. However, the difference was not significant. Thus, brucellosis patients have at least a 27% chance of developing osteoarticular disease. CONCLUSIONS:The prevalence of OAB is not dependent on the endemicity of brucellosis in a particular region. Hence, further research should investigate the potential mechanisms of OAB, as well as the influence of age, gender, and other socioeconomic factor variations in its global prevalence, as this may provide insight into associated exposure risks and management of the disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 1 e0007112 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Shakirat A Adetunji Gilbert Ramirez Margaret J Foster Angela M Arenas-Gamboa A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Infection of bones and joints remains one of the most commonly described complications of brucellosis in humans and is predominantly reported in all ages and sexes in high-risk regions, such as the Middle East, Asia, South and Central America, and Africa. We aimed to systematically review the literature and perform a meta-analysis to estimate the global prevalence of osteoarticular brucellosis (OAB). METHODOLOGY:Major bibliographic databases were searched using keywords and suitable combinations. All studies reporting the incidence and clinical manifestations of osteoarticular brucellosis in humans, and demonstrated by two or more diagnostic methods (bacteriological, molecular, serological, and/or radiographic) were included. Random model was used, and statistical significance was set at 0.05. PRINCIPAL FINDINGS:A total of 56 studies met the inclusion criteria and were included in the systematic review and meta-analysis. There was an evidence of geographical variation in the prevalence of osteoarticular disease with estimates ranging from 27% in low-risk regions to 36% in high-risk regions. However, the difference was not significant. Thus, brucellosis patients have at least a 27% chance of developing osteoarticular disease. CONCLUSIONS:The prevalence of OAB is not dependent on the endemicity of brucellosis in a particular region. Hence, further research should investigate the potential mechanisms of OAB, as well as the influence of age, gender, and other socioeconomic factor variations in its global prevalence, as this may provide insight into associated exposure risks and management of the disease. |
format |
Article in Journal/Newspaper |
author |
Shakirat A Adetunji Gilbert Ramirez Margaret J Foster Angela M Arenas-Gamboa |
author_facet |
Shakirat A Adetunji Gilbert Ramirez Margaret J Foster Angela M Arenas-Gamboa |
author_sort |
Shakirat A Adetunji |
title |
A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. |
title_short |
A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. |
title_full |
A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. |
title_fullStr |
A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. |
title_full_unstemmed |
A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. |
title_sort |
systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007112 https://doaj.org/article/27a6d2982c384a5789d4e580ca5e5ed7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0007112 (2019) |
op_relation |
http://europepmc.org/articles/PMC6355028?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007112 https://doaj.org/article/27a6d2982c384a5789d4e580ca5e5ed7 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007112 |
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PLOS Neglected Tropical Diseases |
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13 |
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1 |
container_start_page |
e0007112 |
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