Toxoplasmosis in patients with an autoimmune disease and immunosuppressive agents: A multicenter study and literature review.
Background Cases of Toxoplasma reactivation or more severe primary infection have been reported in patients receiving immunosuppressive (IS) treatment for autoimmune diseases (AID). The purpose of this study was to describe features of toxoplasmosis occurring in patients with AID treated by IS thera...
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ftdoajarticles:oai:doaj.org/article:2789fc2799b3481e8c556c2c321dfd30 2023-05-15T15:08:23+02:00 Toxoplasmosis in patients with an autoimmune disease and immunosuppressive agents: A multicenter study and literature review. Marie-Fleur Durieux Jean-Guillaume Lopez Maher Banjari Karine Passebosc-Faure Marie-Pierre Brenier-Pinchart Luc Paris Gilles Gargala Sabine Berthier Julie Bonhomme Cathy Chemla Isabelle Villena Pierre Flori Emilie Fréalle Coralie L'Ollivier Florian Lussac-Sorton José Gilberto Montoya Estelle Cateau Christelle Pomares Loïc Simon Dorothée Quinio Florence Robert-Gangneux Hélène Yera Marc Labriffe Anne-Laure Fauchais Marie-Laure Dardé 2022-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010691 https://doaj.org/article/2789fc2799b3481e8c556c2c321dfd30 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010691 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010691 https://doaj.org/article/2789fc2799b3481e8c556c2c321dfd30 PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010691 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010691 2022-12-30T23:42:59Z Background Cases of Toxoplasma reactivation or more severe primary infection have been reported in patients receiving immunosuppressive (IS) treatment for autoimmune diseases (AID). The purpose of this study was to describe features of toxoplasmosis occurring in patients with AID treated by IS therapy, excluded HIV-positive and transplant patients. Methods A multicenter descriptive study was conducted using data from the French National Reference Center for Toxoplasmosis (NRCT) that received DNA extracts or strains isolated from patients, associated with clinical data. Other cases were retrieved through a questionnaire sent to all French parasitology and internal medicine departments. Furthermore, a systematic literature review was conducted. Results 61 cases were collected: 25 retrieved by the NRCT and by a call for observations and 36 from a literature review. Half of the cases were attributed to reactivation (50.9%), and most of cases (49.2%) were cerebral toxoplasmosis. The most common associated AID were rheumatoid arthritis (28%) and most frequent treatments were antimetabolites (44.3%). Corticosteroids were involved in 60.7% of cases. Patients had a favorable outcome (50.8%) but nine did not survive. For 12 cases, a successful Toxoplasma strain characterization suggested the possible role of this parasitic factor in ocular cases. Conclusion Although this remains a rare condition, clinicians should be aware for the management of patients and for the choice of IS treatment. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 8 e0010691 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Marie-Fleur Durieux Jean-Guillaume Lopez Maher Banjari Karine Passebosc-Faure Marie-Pierre Brenier-Pinchart Luc Paris Gilles Gargala Sabine Berthier Julie Bonhomme Cathy Chemla Isabelle Villena Pierre Flori Emilie Fréalle Coralie L'Ollivier Florian Lussac-Sorton José Gilberto Montoya Estelle Cateau Christelle Pomares Loïc Simon Dorothée Quinio Florence Robert-Gangneux Hélène Yera Marc Labriffe Anne-Laure Fauchais Marie-Laure Dardé Toxoplasmosis in patients with an autoimmune disease and immunosuppressive agents: A multicenter study and literature review. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Cases of Toxoplasma reactivation or more severe primary infection have been reported in patients receiving immunosuppressive (IS) treatment for autoimmune diseases (AID). The purpose of this study was to describe features of toxoplasmosis occurring in patients with AID treated by IS therapy, excluded HIV-positive and transplant patients. Methods A multicenter descriptive study was conducted using data from the French National Reference Center for Toxoplasmosis (NRCT) that received DNA extracts or strains isolated from patients, associated with clinical data. Other cases were retrieved through a questionnaire sent to all French parasitology and internal medicine departments. Furthermore, a systematic literature review was conducted. Results 61 cases were collected: 25 retrieved by the NRCT and by a call for observations and 36 from a literature review. Half of the cases were attributed to reactivation (50.9%), and most of cases (49.2%) were cerebral toxoplasmosis. The most common associated AID were rheumatoid arthritis (28%) and most frequent treatments were antimetabolites (44.3%). Corticosteroids were involved in 60.7% of cases. Patients had a favorable outcome (50.8%) but nine did not survive. For 12 cases, a successful Toxoplasma strain characterization suggested the possible role of this parasitic factor in ocular cases. Conclusion Although this remains a rare condition, clinicians should be aware for the management of patients and for the choice of IS treatment. |
format |
Article in Journal/Newspaper |
author |
Marie-Fleur Durieux Jean-Guillaume Lopez Maher Banjari Karine Passebosc-Faure Marie-Pierre Brenier-Pinchart Luc Paris Gilles Gargala Sabine Berthier Julie Bonhomme Cathy Chemla Isabelle Villena Pierre Flori Emilie Fréalle Coralie L'Ollivier Florian Lussac-Sorton José Gilberto Montoya Estelle Cateau Christelle Pomares Loïc Simon Dorothée Quinio Florence Robert-Gangneux Hélène Yera Marc Labriffe Anne-Laure Fauchais Marie-Laure Dardé |
author_facet |
Marie-Fleur Durieux Jean-Guillaume Lopez Maher Banjari Karine Passebosc-Faure Marie-Pierre Brenier-Pinchart Luc Paris Gilles Gargala Sabine Berthier Julie Bonhomme Cathy Chemla Isabelle Villena Pierre Flori Emilie Fréalle Coralie L'Ollivier Florian Lussac-Sorton José Gilberto Montoya Estelle Cateau Christelle Pomares Loïc Simon Dorothée Quinio Florence Robert-Gangneux Hélène Yera Marc Labriffe Anne-Laure Fauchais Marie-Laure Dardé |
author_sort |
Marie-Fleur Durieux |
title |
Toxoplasmosis in patients with an autoimmune disease and immunosuppressive agents: A multicenter study and literature review. |
title_short |
Toxoplasmosis in patients with an autoimmune disease and immunosuppressive agents: A multicenter study and literature review. |
title_full |
Toxoplasmosis in patients with an autoimmune disease and immunosuppressive agents: A multicenter study and literature review. |
title_fullStr |
Toxoplasmosis in patients with an autoimmune disease and immunosuppressive agents: A multicenter study and literature review. |
title_full_unstemmed |
Toxoplasmosis in patients with an autoimmune disease and immunosuppressive agents: A multicenter study and literature review. |
title_sort |
toxoplasmosis in patients with an autoimmune disease and immunosuppressive agents: a multicenter study and literature review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010691 https://doaj.org/article/2789fc2799b3481e8c556c2c321dfd30 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010691 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010691 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010691 https://doaj.org/article/2789fc2799b3481e8c556c2c321dfd30 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010691 |
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PLOS Neglected Tropical Diseases |
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16 |
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8 |
container_start_page |
e0010691 |
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1766339761866276864 |