Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients

• Main Authors: Saheb Sharif-Askari F, Saheb Sharif-Askari N, Guella A, Alabdullah A, Bashar Al Sheleh H, Maher Hoory AlRawi A, Sami Haddad E, Hamid Q, Halwani R, Hamoudi R
• Format: Article in Journal/Newspaper
• Language: English
• Published: Dove Medical Press 2020
• Subjects: extended-spectrum ß-lactamase; klebsiella pneumoniae; escherichia coli; urinary tract infection; c-reactive protein; survival; Infectious and parasitic diseases; RC109-216; Maher; sami
• Online Access: https://doaj.org/article/2742322af4e546628805789d6fcb8017

Fatemeh Saheb Sharif-Askari,1 Narjes Saheb Sharif-Askari,1 Adnane Guella,2 Ali Alabdullah,1,* Hour Bashar Al Sheleh,1,* Afnan Maher Hoory AlRawi,1,* Enad Sami Haddad,1,* Qutayba Hamid,1,3 Rabih Halwani,1,3,4 Rifat Hamoudi1,3 1Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; 2Department of Nephrology, University Hospital Sharjah, Sharjah, United Arab Emirates; 3Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; 4Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia*These authors contributed equally to this workCorrespondence: Rifat Hamoudi; Rabih HalwaniCollege of Medicine, University of Sharjah, Sharjah, United Arab EmiratesEmail [e-mail]; [e-mail]: Extended-spectrum ß-lactamase (ESBL)-producing Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) are the most common uropathogens causing UTI (urinary tract infection) in type 2 diabetes mellitus (T2DM). Circulatory inflammatory markers such as C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) are usually dysregulated during UTI. However, the differential regulation of these inflammatory signatures during E. coli and K. pneumoniae UTI in T2DM has not been determined.Methods: A case–control study on 466 patients was performed to investigate the inflammatory signatures indicative of ESBL-E. coli and K. pneumoniae UTIs in T2DM. Serum CRP levels and blood NLR for these patients were determined and associated with E. coli and K. pneumoniae ESBL uropathogen using multivariate logistic regression analysis. Urinary interleukin 8 (IL-8) levels were also assessed and associated with these two UTI uropathogens in T2DM. The association of the two ESBL-uropathogens with the survival outcomes of T2DM patients was also analyzed using Cox-proportional hazard model.Results: T2DM patients with ESBL-E. ...