Krill Oil Improves Mild Knee Joint Pain: A Randomized Control Trial.
Krill oil is an edible oil extracted from krill, a small red-colored crustacean found in the Antarctic Ocean. The administration of krill oil is reported to mitigate inflammation in patients with cardiac disease, rheumatoid arthritis, or osteoarthritis. However, the effect of krill oil on mild knee...
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ftdoajarticles:oai:doaj.org/article:2740f45d99c4475b80976d664af0bed0 2023-05-15T13:45:14+02:00 Krill Oil Improves Mild Knee Joint Pain: A Randomized Control Trial. Yoshio Suzuki Minoru Fukushima Keishoku Sakuraba Keisuke Sawaki Kazuaki Sekigawa 2016-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0162769 https://doaj.org/article/2740f45d99c4475b80976d664af0bed0 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5049853?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0162769 https://doaj.org/article/2740f45d99c4475b80976d664af0bed0 PLoS ONE, Vol 11, Iss 10, p e0162769 (2016) Medicine R Science Q article 2016 ftdoajarticles https://doi.org/10.1371/journal.pone.0162769 2022-12-30T23:37:53Z Krill oil is an edible oil extracted from krill, a small red-colored crustacean found in the Antarctic Ocean. The administration of krill oil is reported to mitigate inflammation in patients with cardiac disease, rheumatoid arthritis, or osteoarthritis. However, the effect of krill oil on mild knee pain has not yet been determined.To assess the effect of krill oil on mild knee pain.A randomized, double-blind, parallel-group, placebo-controlled trial of fifty adults (38-85 years old) with mild knee pain attending the Fukushima Orthopedic Clinic (Tochigi, Japan) between September 2014 and March 2015.Participants were randomized to receive 2 g per day of either krill oil or an identical placebo for 30 days.The primary outcome was improvement in subjective symptoms of knee pain as assessed by the Japanese Knee Osteoarthritis Measure (JKOM) and Japanese Orthopaedic Association score (JOA). Secondary outcomes included blood and urine biochemical parameters.Both the placebo and krill oil groups showed significant improvements in the questions in the JKOM and JOA questionnaires after administration. After the intervention, krill oil group showed more improvements than placebo group in two questions regarding the pain and stiffness in knees in JKOM. Controlling for age, sex, weight, and smoking and drinking habits, krill oil significantly mitigated knee pain in sleeping (P < 0.001), standing (P < 0.001) and the range of motion of both right and left knees (both P = 0.011) compared to placebo. Krill oil administration raised plasma EPA (P = 0.048) and EPA/AA ratio (P = 0.003).This study indicates that krill oil administration (2 g/day, 30 days) improved the subjective symptoms of knee pain in adults with mild knee pain.UMIN-CTR; ID UMIN000014413. Article in Journal/Newspaper Antarc* Antarctic Antarctic Ocean Directory of Open Access Journals: DOAJ Articles Antarctic Antarctic Ocean Fukushima The Antarctic PLOS ONE 11 10 e0162769 |
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topic |
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Medicine R Science Q Yoshio Suzuki Minoru Fukushima Keishoku Sakuraba Keisuke Sawaki Kazuaki Sekigawa Krill Oil Improves Mild Knee Joint Pain: A Randomized Control Trial. |
topic_facet |
Medicine R Science Q |
description |
Krill oil is an edible oil extracted from krill, a small red-colored crustacean found in the Antarctic Ocean. The administration of krill oil is reported to mitigate inflammation in patients with cardiac disease, rheumatoid arthritis, or osteoarthritis. However, the effect of krill oil on mild knee pain has not yet been determined.To assess the effect of krill oil on mild knee pain.A randomized, double-blind, parallel-group, placebo-controlled trial of fifty adults (38-85 years old) with mild knee pain attending the Fukushima Orthopedic Clinic (Tochigi, Japan) between September 2014 and March 2015.Participants were randomized to receive 2 g per day of either krill oil or an identical placebo for 30 days.The primary outcome was improvement in subjective symptoms of knee pain as assessed by the Japanese Knee Osteoarthritis Measure (JKOM) and Japanese Orthopaedic Association score (JOA). Secondary outcomes included blood and urine biochemical parameters.Both the placebo and krill oil groups showed significant improvements in the questions in the JKOM and JOA questionnaires after administration. After the intervention, krill oil group showed more improvements than placebo group in two questions regarding the pain and stiffness in knees in JKOM. Controlling for age, sex, weight, and smoking and drinking habits, krill oil significantly mitigated knee pain in sleeping (P < 0.001), standing (P < 0.001) and the range of motion of both right and left knees (both P = 0.011) compared to placebo. Krill oil administration raised plasma EPA (P = 0.048) and EPA/AA ratio (P = 0.003).This study indicates that krill oil administration (2 g/day, 30 days) improved the subjective symptoms of knee pain in adults with mild knee pain.UMIN-CTR; ID UMIN000014413. |
format |
Article in Journal/Newspaper |
author |
Yoshio Suzuki Minoru Fukushima Keishoku Sakuraba Keisuke Sawaki Kazuaki Sekigawa |
author_facet |
Yoshio Suzuki Minoru Fukushima Keishoku Sakuraba Keisuke Sawaki Kazuaki Sekigawa |
author_sort |
Yoshio Suzuki |
title |
Krill Oil Improves Mild Knee Joint Pain: A Randomized Control Trial. |
title_short |
Krill Oil Improves Mild Knee Joint Pain: A Randomized Control Trial. |
title_full |
Krill Oil Improves Mild Knee Joint Pain: A Randomized Control Trial. |
title_fullStr |
Krill Oil Improves Mild Knee Joint Pain: A Randomized Control Trial. |
title_full_unstemmed |
Krill Oil Improves Mild Knee Joint Pain: A Randomized Control Trial. |
title_sort |
krill oil improves mild knee joint pain: a randomized control trial. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pone.0162769 https://doaj.org/article/2740f45d99c4475b80976d664af0bed0 |
geographic |
Antarctic Antarctic Ocean Fukushima The Antarctic |
geographic_facet |
Antarctic Antarctic Ocean Fukushima The Antarctic |
genre |
Antarc* Antarctic Antarctic Ocean |
genre_facet |
Antarc* Antarctic Antarctic Ocean |
op_source |
PLoS ONE, Vol 11, Iss 10, p e0162769 (2016) |
op_relation |
http://europepmc.org/articles/PMC5049853?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0162769 https://doaj.org/article/2740f45d99c4475b80976d664af0bed0 |
op_doi |
https://doi.org/10.1371/journal.pone.0162769 |
container_title |
PLOS ONE |
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11 |
container_issue |
10 |
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e0162769 |
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