Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers
Introduction Chronic hepatitis B virus (HBV) infection and liver steatosis (LS) are the most common causes of chronic liver disease, and their coexistence is frequently observed in clinical practice. Although metabolic syndrome is the main cause of LS, it has not been associated with HBV infection....
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ftdoajarticles:oai:doaj.org/article:27328fe6bb3f4550b5872a44445f1354 2023-05-15T15:09:24+02:00 Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers Angélica Luciana Nau Júlia Cristina Soares Maria Beatriz Cacese Shiozawa Esther Buzaglo Dantas-Corrêa Leonardo de Lucca Schiavon Janaína Luz Narciso-Schiavon 2014-04-01T00:00:00Z https://doi.org/10.1590/0037-8682-0009-2014 https://doaj.org/article/27328fe6bb3f4550b5872a44445f1354 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000200158&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0009-2014 https://doaj.org/article/27328fe6bb3f4550b5872a44445f1354 Revista da Sociedade Brasileira de Medicina Tropical, Vol 47, Iss 2, Pp 158-164 (2014) HBV Hepatitis B Fatty liver Lipids Cholesterol Triglycerides Arctic medicine. Tropical medicine RC955-962 article 2014 ftdoajarticles https://doi.org/10.1590/0037-8682-0009-2014 2022-12-31T03:01:13Z Introduction Chronic hepatitis B virus (HBV) infection and liver steatosis (LS) are the most common causes of chronic liver disease, and their coexistence is frequently observed in clinical practice. Although metabolic syndrome is the main cause of LS, it has not been associated with HBV infection. The aims of this study were to describe the lipid profile and prevalence of LS among HBV carriers and to identify the characteristics associated with LS in this group. Methods This retrospective cross-sectional study included hepatitis B surface antigen (HBsAg)-positive patients evaluated during 2011 and 2012. Results Of the 83 patients included, the mean age was 46.4±12.5 years, 53% were men, and 9.1% were hepatitis B e antigen (HBeAg) -positive. These patients exhibited the following lipid profile: total cholesterol = 175.4±38.8mg/dL, low-density lipoprotein (LDL) = 113.0±32.7mg/dL, and triglycerides = 91.1±45.2mg/dL. Their fasting glucose was 95.3±14.5g/dL, and fasting insulin was 6.1±5.9µIU/mL. Liver steatosis was observed on abdominal ultrasound in 11.3% of individuals. Factors associated with the presence of LS included higher levels of total cholesterol, prothrombin activity, fasting insulin, and body mass index (BMI) as well as lower levels of aspartate aminotransferase (AST). Conclusions These findings suggest that LS in patients with chronic HBV appears to be a consequence of metabolic alterations and insulin action rather than of viral factors. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 47 2 158 164 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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HBV Hepatitis B Fatty liver Lipids Cholesterol Triglycerides Arctic medicine. Tropical medicine RC955-962 |
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HBV Hepatitis B Fatty liver Lipids Cholesterol Triglycerides Arctic medicine. Tropical medicine RC955-962 Angélica Luciana Nau Júlia Cristina Soares Maria Beatriz Cacese Shiozawa Esther Buzaglo Dantas-Corrêa Leonardo de Lucca Schiavon Janaína Luz Narciso-Schiavon Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers |
topic_facet |
HBV Hepatitis B Fatty liver Lipids Cholesterol Triglycerides Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction Chronic hepatitis B virus (HBV) infection and liver steatosis (LS) are the most common causes of chronic liver disease, and their coexistence is frequently observed in clinical practice. Although metabolic syndrome is the main cause of LS, it has not been associated with HBV infection. The aims of this study were to describe the lipid profile and prevalence of LS among HBV carriers and to identify the characteristics associated with LS in this group. Methods This retrospective cross-sectional study included hepatitis B surface antigen (HBsAg)-positive patients evaluated during 2011 and 2012. Results Of the 83 patients included, the mean age was 46.4±12.5 years, 53% were men, and 9.1% were hepatitis B e antigen (HBeAg) -positive. These patients exhibited the following lipid profile: total cholesterol = 175.4±38.8mg/dL, low-density lipoprotein (LDL) = 113.0±32.7mg/dL, and triglycerides = 91.1±45.2mg/dL. Their fasting glucose was 95.3±14.5g/dL, and fasting insulin was 6.1±5.9µIU/mL. Liver steatosis was observed on abdominal ultrasound in 11.3% of individuals. Factors associated with the presence of LS included higher levels of total cholesterol, prothrombin activity, fasting insulin, and body mass index (BMI) as well as lower levels of aspartate aminotransferase (AST). Conclusions These findings suggest that LS in patients with chronic HBV appears to be a consequence of metabolic alterations and insulin action rather than of viral factors. |
format |
Article in Journal/Newspaper |
author |
Angélica Luciana Nau Júlia Cristina Soares Maria Beatriz Cacese Shiozawa Esther Buzaglo Dantas-Corrêa Leonardo de Lucca Schiavon Janaína Luz Narciso-Schiavon |
author_facet |
Angélica Luciana Nau Júlia Cristina Soares Maria Beatriz Cacese Shiozawa Esther Buzaglo Dantas-Corrêa Leonardo de Lucca Schiavon Janaína Luz Narciso-Schiavon |
author_sort |
Angélica Luciana Nau |
title |
Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers |
title_short |
Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers |
title_full |
Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers |
title_fullStr |
Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers |
title_full_unstemmed |
Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers |
title_sort |
clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic hbv carriers |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2014 |
url |
https://doi.org/10.1590/0037-8682-0009-2014 https://doaj.org/article/27328fe6bb3f4550b5872a44445f1354 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 47, Iss 2, Pp 158-164 (2014) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000200158&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0009-2014 https://doaj.org/article/27328fe6bb3f4550b5872a44445f1354 |
op_doi |
https://doi.org/10.1590/0037-8682-0009-2014 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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47 |
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