Azithromycin-liposomes as a novel approach for localized therapy of cervicovaginal bacterial infections
Željka Vanić,1 Zora Rukavina,1 Suvi Manner,2 Adyary Fallarero,3 Lidija Uzelac,4 Marijeta Kralj,4 Daniela Amidžić Klarić,1 Anita Bogdanov,5 Tímea Raffai,5 Dezső Peter Virok,5 Jelena Filipović-Grčić,1 Nataša Škalko-Basnet61Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry,...
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ftdoajarticles:oai:doaj.org/article:273087be414a48c2bf30c07660c8faa1 2023-05-15T18:49:26+02:00 Azithromycin-liposomes as a novel approach for localized therapy of cervicovaginal bacterial infections Vanić Ž Rukavina Z Manner S Fallarero A Uzelac L Kralj M Amidžić Klarić D Bogdanov A Raffai T Virok DP Filipović-Grčić J Škalko-Basnet N 2019-07-01T00:00:00Z https://doaj.org/article/273087be414a48c2bf30c07660c8faa1 EN eng Dove Medical Press https://www.dovepress.com/azithromycin-liposomes-as-a-novel-approach-for-localized-therapy-of-ce-peer-reviewed-article-IJN https://doaj.org/toc/1178-2013 1178-2013 https://doaj.org/article/273087be414a48c2bf30c07660c8faa1 International Journal of Nanomedicine, Vol Volume 14, Pp 5957-5976 (2019) Vaginal drug delivery Biofilm Escherichia coli Chlamydia trachomatis Cervical cells Biocompatibility Medicine (General) R5-920 article 2019 ftdoajarticles 2022-12-31T08:01:44Z Željka Vanić,1 Zora Rukavina,1 Suvi Manner,2 Adyary Fallarero,3 Lidija Uzelac,4 Marijeta Kralj,4 Daniela Amidžić Klarić,1 Anita Bogdanov,5 Tímea Raffai,5 Dezső Peter Virok,5 Jelena Filipović-Grčić,1 Nataša Škalko-Basnet61Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia; 2Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi and University of Helsinki, 20520 Turku, Finland; 3Division of Pharmaceutical Biosciences, Pharmaceutical Biology, Faculty of Pharmacy, University of Helsinki, 00014 Helsinki, Finland; 4Department of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia; 5Department of Medical Microbiology and Immunobiology, University of Szeged, 6720 Szeged, Hungary; 6Drug Transport and Delivery Research Group, Department of Pharmacy, Faculty of Health Sciences, University of Tromsø the Arctic University of Norway, 5037 Tromsø, NorwayBackground: Efficient localized cervicovaginal antibacterial therapy, enabling the delivery of antibiotic to the site of action at lower doses while escaping systemic drug effects and reducing the risk of developing microbial resistance, is attracting considerable attention. Liposomes have been shown to allow sustained drug release into vaginal mucosa and improve delivery of antibiotics to bacterial cells and biofilms. Azithromycin (AZI), a potent broad-spectrum macrolide antibiotic, has not yet been investigated for localized therapy of cervicovaginal infections, although it is administered orally for the treatment of sexually transmitted diseases. Encapsulation of AZI in liposomes could improve its solubility, antibacterial activity, and allow the prolonged drug release in the cervicovaginal tissue, while avoiding systemic side effects.Purpose: The objective of this study was to develop AZI-liposomes and explore their potentials for treating cervicovaginal infections.Methods: AZI-liposomes that differed in bilayer elasticity/rigidity and surface charge were ... Article in Journal/Newspaper Arctic University of Norway University of Tromsø Directory of Open Access Journals: DOAJ Articles Arctic Norway Tromsø |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Vaginal drug delivery Biofilm Escherichia coli Chlamydia trachomatis Cervical cells Biocompatibility Medicine (General) R5-920 |
spellingShingle |
Vaginal drug delivery Biofilm Escherichia coli Chlamydia trachomatis Cervical cells Biocompatibility Medicine (General) R5-920 Vanić Ž Rukavina Z Manner S Fallarero A Uzelac L Kralj M Amidžić Klarić D Bogdanov A Raffai T Virok DP Filipović-Grčić J Škalko-Basnet N Azithromycin-liposomes as a novel approach for localized therapy of cervicovaginal bacterial infections |
topic_facet |
Vaginal drug delivery Biofilm Escherichia coli Chlamydia trachomatis Cervical cells Biocompatibility Medicine (General) R5-920 |
description |
Željka Vanić,1 Zora Rukavina,1 Suvi Manner,2 Adyary Fallarero,3 Lidija Uzelac,4 Marijeta Kralj,4 Daniela Amidžić Klarić,1 Anita Bogdanov,5 Tímea Raffai,5 Dezső Peter Virok,5 Jelena Filipović-Grčić,1 Nataša Škalko-Basnet61Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia; 2Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi and University of Helsinki, 20520 Turku, Finland; 3Division of Pharmaceutical Biosciences, Pharmaceutical Biology, Faculty of Pharmacy, University of Helsinki, 00014 Helsinki, Finland; 4Department of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia; 5Department of Medical Microbiology and Immunobiology, University of Szeged, 6720 Szeged, Hungary; 6Drug Transport and Delivery Research Group, Department of Pharmacy, Faculty of Health Sciences, University of Tromsø the Arctic University of Norway, 5037 Tromsø, NorwayBackground: Efficient localized cervicovaginal antibacterial therapy, enabling the delivery of antibiotic to the site of action at lower doses while escaping systemic drug effects and reducing the risk of developing microbial resistance, is attracting considerable attention. Liposomes have been shown to allow sustained drug release into vaginal mucosa and improve delivery of antibiotics to bacterial cells and biofilms. Azithromycin (AZI), a potent broad-spectrum macrolide antibiotic, has not yet been investigated for localized therapy of cervicovaginal infections, although it is administered orally for the treatment of sexually transmitted diseases. Encapsulation of AZI in liposomes could improve its solubility, antibacterial activity, and allow the prolonged drug release in the cervicovaginal tissue, while avoiding systemic side effects.Purpose: The objective of this study was to develop AZI-liposomes and explore their potentials for treating cervicovaginal infections.Methods: AZI-liposomes that differed in bilayer elasticity/rigidity and surface charge were ... |
format |
Article in Journal/Newspaper |
author |
Vanić Ž Rukavina Z Manner S Fallarero A Uzelac L Kralj M Amidžić Klarić D Bogdanov A Raffai T Virok DP Filipović-Grčić J Škalko-Basnet N |
author_facet |
Vanić Ž Rukavina Z Manner S Fallarero A Uzelac L Kralj M Amidžić Klarić D Bogdanov A Raffai T Virok DP Filipović-Grčić J Škalko-Basnet N |
author_sort |
Vanić Ž |
title |
Azithromycin-liposomes as a novel approach for localized therapy of cervicovaginal bacterial infections |
title_short |
Azithromycin-liposomes as a novel approach for localized therapy of cervicovaginal bacterial infections |
title_full |
Azithromycin-liposomes as a novel approach for localized therapy of cervicovaginal bacterial infections |
title_fullStr |
Azithromycin-liposomes as a novel approach for localized therapy of cervicovaginal bacterial infections |
title_full_unstemmed |
Azithromycin-liposomes as a novel approach for localized therapy of cervicovaginal bacterial infections |
title_sort |
azithromycin-liposomes as a novel approach for localized therapy of cervicovaginal bacterial infections |
publisher |
Dove Medical Press |
publishDate |
2019 |
url |
https://doaj.org/article/273087be414a48c2bf30c07660c8faa1 |
geographic |
Arctic Norway Tromsø |
geographic_facet |
Arctic Norway Tromsø |
genre |
Arctic University of Norway University of Tromsø |
genre_facet |
Arctic University of Norway University of Tromsø |
op_source |
International Journal of Nanomedicine, Vol Volume 14, Pp 5957-5976 (2019) |
op_relation |
https://www.dovepress.com/azithromycin-liposomes-as-a-novel-approach-for-localized-therapy-of-ce-peer-reviewed-article-IJN https://doaj.org/toc/1178-2013 1178-2013 https://doaj.org/article/273087be414a48c2bf30c07660c8faa1 |
_version_ |
1766243035897659392 |