Genomic epidemiology of Campylobacter jejuni associated with asymptomatic pediatric infection in the Peruvian Amazon.
Campylobacter is the leading bacterial cause of gastroenteritis worldwide and its incidence is especially high in low- and middle-income countries (LMIC). Disease epidemiology in LMICs is different compared to high income countries like the USA or in Europe. Children in LMICs commonly have repeated...
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ftdoajarticles:oai:doaj.org/article:272cc218fba44be9baed520bb330cbed 2023-05-15T15:07:54+02:00 Genomic epidemiology of Campylobacter jejuni associated with asymptomatic pediatric infection in the Peruvian Amazon. Ben Pascoe Francesca Schiaffino Susan Murray Guillaume Méric Sion C Bayliss Matthew D Hitchings Evangelos Mourkas Jessica K Calland Rosa Burga Pablo Peñataro Yori Keith A Jolley Kerry K Cooper Craig T Parker Maribel Paredes Olortegui Margaret N Kosek Samuel K Sheppard 2020-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008533 https://doaj.org/article/272cc218fba44be9baed520bb330cbed EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008533 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008533 https://doaj.org/article/272cc218fba44be9baed520bb330cbed PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008533 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008533 2022-12-31T10:37:01Z Campylobacter is the leading bacterial cause of gastroenteritis worldwide and its incidence is especially high in low- and middle-income countries (LMIC). Disease epidemiology in LMICs is different compared to high income countries like the USA or in Europe. Children in LMICs commonly have repeated and chronic infections even in the absence of symptoms, which can lead to deficits in early childhood development. In this study, we sequenced and characterized C. jejuni (n = 62) from a longitudinal cohort study of children under the age of 5 with and without diarrheal symptoms, and contextualized them within a global C. jejuni genome collection. Epidemiological differences in disease presentation were reflected in the genomes, specifically by the absence of some of the most common global disease-causing lineages. As in many other countries, poultry-associated strains were likely a major source of human infection but almost half of local disease cases (15 of 31) were attributable to genotypes that are rare outside of Peru. Asymptomatic infection was not limited to a single (or few) human adapted lineages but resulted from phylogenetically divergent strains suggesting an important role for host factors in the cryptic epidemiology of campylobacteriosis in LMICs. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 8 e0008533 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ben Pascoe Francesca Schiaffino Susan Murray Guillaume Méric Sion C Bayliss Matthew D Hitchings Evangelos Mourkas Jessica K Calland Rosa Burga Pablo Peñataro Yori Keith A Jolley Kerry K Cooper Craig T Parker Maribel Paredes Olortegui Margaret N Kosek Samuel K Sheppard Genomic epidemiology of Campylobacter jejuni associated with asymptomatic pediatric infection in the Peruvian Amazon. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Campylobacter is the leading bacterial cause of gastroenteritis worldwide and its incidence is especially high in low- and middle-income countries (LMIC). Disease epidemiology in LMICs is different compared to high income countries like the USA or in Europe. Children in LMICs commonly have repeated and chronic infections even in the absence of symptoms, which can lead to deficits in early childhood development. In this study, we sequenced and characterized C. jejuni (n = 62) from a longitudinal cohort study of children under the age of 5 with and without diarrheal symptoms, and contextualized them within a global C. jejuni genome collection. Epidemiological differences in disease presentation were reflected in the genomes, specifically by the absence of some of the most common global disease-causing lineages. As in many other countries, poultry-associated strains were likely a major source of human infection but almost half of local disease cases (15 of 31) were attributable to genotypes that are rare outside of Peru. Asymptomatic infection was not limited to a single (or few) human adapted lineages but resulted from phylogenetically divergent strains suggesting an important role for host factors in the cryptic epidemiology of campylobacteriosis in LMICs. |
format |
Article in Journal/Newspaper |
author |
Ben Pascoe Francesca Schiaffino Susan Murray Guillaume Méric Sion C Bayliss Matthew D Hitchings Evangelos Mourkas Jessica K Calland Rosa Burga Pablo Peñataro Yori Keith A Jolley Kerry K Cooper Craig T Parker Maribel Paredes Olortegui Margaret N Kosek Samuel K Sheppard |
author_facet |
Ben Pascoe Francesca Schiaffino Susan Murray Guillaume Méric Sion C Bayliss Matthew D Hitchings Evangelos Mourkas Jessica K Calland Rosa Burga Pablo Peñataro Yori Keith A Jolley Kerry K Cooper Craig T Parker Maribel Paredes Olortegui Margaret N Kosek Samuel K Sheppard |
author_sort |
Ben Pascoe |
title |
Genomic epidemiology of Campylobacter jejuni associated with asymptomatic pediatric infection in the Peruvian Amazon. |
title_short |
Genomic epidemiology of Campylobacter jejuni associated with asymptomatic pediatric infection in the Peruvian Amazon. |
title_full |
Genomic epidemiology of Campylobacter jejuni associated with asymptomatic pediatric infection in the Peruvian Amazon. |
title_fullStr |
Genomic epidemiology of Campylobacter jejuni associated with asymptomatic pediatric infection in the Peruvian Amazon. |
title_full_unstemmed |
Genomic epidemiology of Campylobacter jejuni associated with asymptomatic pediatric infection in the Peruvian Amazon. |
title_sort |
genomic epidemiology of campylobacter jejuni associated with asymptomatic pediatric infection in the peruvian amazon. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008533 https://doaj.org/article/272cc218fba44be9baed520bb330cbed |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008533 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008533 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008533 https://doaj.org/article/272cc218fba44be9baed520bb330cbed |
op_doi |
https://doi.org/10.1371/journal.pntd.0008533 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
14 |
container_issue |
8 |
container_start_page |
e0008533 |
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