Therapeutical evaluation of different dose regimens of praziquantel in schistosomiasis mansoni, based on the quantitative oogram technique
A clinical trial involving 80 patients of both sexes, from ages 15 to 55, with chronic intestinal or hepatointestinal schistosomiasis mansoni, was carried out to evaluate the therapeutical efficacy of different dose regimens of praziquantel. The patients were randomly allocated into four groups with...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
1987
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Online Access: | https://doi.org/10.1590/S0036-46651987000500006 https://doaj.org/article/26efb802ec874c35b0a5c3460931a83c |
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ftdoajarticles:oai:doaj.org/article:26efb802ec874c35b0a5c3460931a83c 2024-09-09T19:28:38+00:00 Therapeutical evaluation of different dose regimens of praziquantel in schistosomiasis mansoni, based on the quantitative oogram technique Aloísio Sales da Cunha J. Romeu Cançado Getúlio Leonel de Rezende 1987-10-01T00:00:00Z https://doi.org/10.1590/S0036-46651987000500006 https://doaj.org/article/26efb802ec874c35b0a5c3460931a83c EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651987000500006&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46651987000500006 https://doaj.org/article/26efb802ec874c35b0a5c3460931a83c Revista do Instituto de Medicina Tropical de São Paulo, Vol 29, Iss 5, Pp 295-304 (1987) Schistosomiasis Praziquantel Oogram Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1987 ftdoajarticles https://doi.org/10.1590/S0036-46651987000500006 2024-08-05T17:49:30Z A clinical trial involving 80 patients of both sexes, from ages 15 to 55, with chronic intestinal or hepatointestinal schistosomiasis mansoni, was carried out to evaluate the therapeutical efficacy of different dose regimens of praziquantel. The patients were randomly allocated into four groups with an equal number of cases and were then treated with one of the following dosages: 60 mg/kg for 1 day; 60 mg/kg daily for 2 days; 60 mg/kg daily for 3 days; and 30 mg/kg daily for 6 days. The assessment of parasitological cure was based on the quantitative oogram technique through rectal mucosa biopsies which were undertaken prior to, as well as, 1,2,4 and 6 months post-treatment. Concurrently, stool examinations according to the qualitative Hoffman, Pons & Janer (HPJ) and the quantitative Kato-Katz (K-K) methods were also performed. The best tolerability was observed with 30 mg/kg daily for 6 days whereas the highest incidence of side-effects (mainly dizziness and nausea) was found with 60 mg/kg daily for 3 days. No serious adverse drug reaction has occurred. The achieved cure rates were: 25% with 60 mg/kg for 1 day; 60% with 60 mg/kg daily for 2 days; 89.5% with 60 mg/kg daily for 3 days; and 90% with 30 mg/kg daily for 6 days. At the same time there has been a downfall of 64%, 73%, 87% and 84% respectively, in the median number of viable S. mansoni ova per gram of tissue. Thus, a very clear direct correlation between dose and effect could be seen. The corresponding cure rates according to stool examinations by HPJ were 39%, 80%, 100% and 95%; by K-K 89%, 100%, 100% and 100%. This discrepancy in results amongst the three parasitological methods is certainly due to their unequal accuracy. In fact, when the number of viable eggs per gram of tissue fell below 5,000 the difference in the percentage of false negative findings between HPJ (28%) and K-K (80%) became significative. When this number dropped to less than 2,000 the percentage of false negative results obtained with HPJ (49%) turned significant in relation ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Downfall ENVELOPE(-62.366,-62.366,-64.800,-64.800) Revista do Instituto de Medicina Tropical de São Paulo 29 5 295 304 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Schistosomiasis Praziquantel Oogram Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Schistosomiasis Praziquantel Oogram Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Aloísio Sales da Cunha J. Romeu Cançado Getúlio Leonel de Rezende Therapeutical evaluation of different dose regimens of praziquantel in schistosomiasis mansoni, based on the quantitative oogram technique |
topic_facet |
Schistosomiasis Praziquantel Oogram Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
A clinical trial involving 80 patients of both sexes, from ages 15 to 55, with chronic intestinal or hepatointestinal schistosomiasis mansoni, was carried out to evaluate the therapeutical efficacy of different dose regimens of praziquantel. The patients were randomly allocated into four groups with an equal number of cases and were then treated with one of the following dosages: 60 mg/kg for 1 day; 60 mg/kg daily for 2 days; 60 mg/kg daily for 3 days; and 30 mg/kg daily for 6 days. The assessment of parasitological cure was based on the quantitative oogram technique through rectal mucosa biopsies which were undertaken prior to, as well as, 1,2,4 and 6 months post-treatment. Concurrently, stool examinations according to the qualitative Hoffman, Pons & Janer (HPJ) and the quantitative Kato-Katz (K-K) methods were also performed. The best tolerability was observed with 30 mg/kg daily for 6 days whereas the highest incidence of side-effects (mainly dizziness and nausea) was found with 60 mg/kg daily for 3 days. No serious adverse drug reaction has occurred. The achieved cure rates were: 25% with 60 mg/kg for 1 day; 60% with 60 mg/kg daily for 2 days; 89.5% with 60 mg/kg daily for 3 days; and 90% with 30 mg/kg daily for 6 days. At the same time there has been a downfall of 64%, 73%, 87% and 84% respectively, in the median number of viable S. mansoni ova per gram of tissue. Thus, a very clear direct correlation between dose and effect could be seen. The corresponding cure rates according to stool examinations by HPJ were 39%, 80%, 100% and 95%; by K-K 89%, 100%, 100% and 100%. This discrepancy in results amongst the three parasitological methods is certainly due to their unequal accuracy. In fact, when the number of viable eggs per gram of tissue fell below 5,000 the difference in the percentage of false negative findings between HPJ (28%) and K-K (80%) became significative. When this number dropped to less than 2,000 the percentage of false negative results obtained with HPJ (49%) turned significant in relation ... |
format |
Article in Journal/Newspaper |
author |
Aloísio Sales da Cunha J. Romeu Cançado Getúlio Leonel de Rezende |
author_facet |
Aloísio Sales da Cunha J. Romeu Cançado Getúlio Leonel de Rezende |
author_sort |
Aloísio Sales da Cunha |
title |
Therapeutical evaluation of different dose regimens of praziquantel in schistosomiasis mansoni, based on the quantitative oogram technique |
title_short |
Therapeutical evaluation of different dose regimens of praziquantel in schistosomiasis mansoni, based on the quantitative oogram technique |
title_full |
Therapeutical evaluation of different dose regimens of praziquantel in schistosomiasis mansoni, based on the quantitative oogram technique |
title_fullStr |
Therapeutical evaluation of different dose regimens of praziquantel in schistosomiasis mansoni, based on the quantitative oogram technique |
title_full_unstemmed |
Therapeutical evaluation of different dose regimens of praziquantel in schistosomiasis mansoni, based on the quantitative oogram technique |
title_sort |
therapeutical evaluation of different dose regimens of praziquantel in schistosomiasis mansoni, based on the quantitative oogram technique |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1987 |
url |
https://doi.org/10.1590/S0036-46651987000500006 https://doaj.org/article/26efb802ec874c35b0a5c3460931a83c |
long_lat |
ENVELOPE(-62.366,-62.366,-64.800,-64.800) |
geographic |
Arctic Downfall |
geographic_facet |
Arctic Downfall |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 29, Iss 5, Pp 295-304 (1987) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651987000500006&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46651987000500006 https://doaj.org/article/26efb802ec874c35b0a5c3460931a83c |
op_doi |
https://doi.org/10.1590/S0036-46651987000500006 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
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29 |
container_issue |
5 |
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295 |
op_container_end_page |
304 |
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