Accuracy of the urine point-of-care circulating cathodic antigen assay for diagnosing Schistosomiasis mansoni infection in Brazil: A multicenter study

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Otavio Sarmento Pieri, Fernando Schemelzer Moraes Bezerra, Paulo Marcos Zech Coelho, Martin Johannes Enk, Tereza Cristina Favre, Carlos Graeff-Teixeira, Ricardo Riccio Oliveira, Mitermayer Galvão dos Reis, Lee Senhorinha de Almeida Andrade, Lilian Christina Nóbrega Holsbach Beck, Vivian Favero, Thainá Rodrigues de Souza Fialho, Ricardo José de Paula Souza e Guimarães, Bruna Souza Santos Oliveira, Vanessa Fey Pascoal, Marta Cristhiany Cunha Pinheiro, Ronald Alves dos Santos, Luciano Kalabric Silva, Isadora Cristina de Siqueira, Renata Perotto de Souza, Naftale Katz
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2023
• Subjects: Schistosoma mansoni; Point-of-care (POC); Circulating cathodic antigen (CCA); Kato-Katz; Helmintex; Brazil; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0238-2022; https://doaj.org/article/2693bf6d885a4936b8f40efcff614e5b

ABSTRACT Background: The World Health Organization recommends a market-ready, urine-based point-of-care diagnostic test for circulating cathodic antigens (CCA) to determine the prevalence of S. mansoni. This study evaluated the performance of the URINE CCA (SCHISTO) ECO TESTE® (POC-ECO), which is currently available in Brazil. Methods: Residents from eight sites with different prevalence estimates provided one urine sample for POC-ECO and one stool sample for Kato-Katz (KK) and Helmintex® (HTX) testing as an egg-detecting reference for infection status. Results: None of the study sites had significantly higher POC-ECO accuracy than KK. Conclusions: POC-ECO is not currently recommended in Brazilian schistosomiasis elimination programs.