Omega-3 Polyunsaturated Fatty Acids and Stroke Burden
Stroke is a major leading cause of death and disability worldwide. N-3 polyunsaturated fatty acids (PUFAs) including eicosapentaenoic acid and docosahexaenoic acid have potent anti-inflammatory effects, reduce platelet aggregation, and regress atherosclerotic plaques. Since the discovery that the Gr...
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ftdoajarticles:oai:doaj.org/article:2674579c3bcc413499b5be2b8f34d2ae 2023-05-15T16:07:11+02:00 Omega-3 Polyunsaturated Fatty Acids and Stroke Burden Yuji Ueno Nobukazu Miyamoto Kazuo Yamashiro Ryota Tanaka Nobutaka Hattori 2019-11-01T00:00:00Z https://doi.org/10.3390/ijms20225549 https://doaj.org/article/2674579c3bcc413499b5be2b8f34d2ae EN eng MDPI AG https://www.mdpi.com/1422-0067/20/22/5549 https://doaj.org/toc/1422-0067 1422-0067 doi:10.3390/ijms20225549 https://doaj.org/article/2674579c3bcc413499b5be2b8f34d2ae International Journal of Molecular Sciences, Vol 20, Iss 22, p 5549 (2019) stroke omega-3 pufa eicosapentaenoic acid docosahexaenoic acid Biology (General) QH301-705.5 Chemistry QD1-999 article 2019 ftdoajarticles https://doi.org/10.3390/ijms20225549 2022-12-31T02:28:05Z Stroke is a major leading cause of death and disability worldwide. N-3 polyunsaturated fatty acids (PUFAs) including eicosapentaenoic acid and docosahexaenoic acid have potent anti-inflammatory effects, reduce platelet aggregation, and regress atherosclerotic plaques. Since the discovery that the Greenland Eskimo population, whose diet is high in marine n-3 PUFAs, have a lower incidence of coronary heart disease than Western populations, numerous epidemiological studies to explore the associations of dietary intakes of fish and n-3 PUFAs with cardiovascular diseases, and large-scale clinical trials to identify the benefits of treatment with n-3 PUFAs have been conducted. In most of these studies the incidence and mortality of stroke were also evaluated mainly as secondary endpoints. Thus, a systematic literature review regarding the association of dietary intake of n-3 PUFAs with stroke in the epidemiological studies and the treatment effects of n-3 PUFAs in the clinical trials was conducted. Moreover, recent experimental studies were also reviewed to explore the molecular mechanisms of the neuroprotective effects of n-3 PUFAs after stroke. Article in Journal/Newspaper eskimo* Greenland Directory of Open Access Journals: DOAJ Articles Greenland International Journal of Molecular Sciences 20 22 5549 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
stroke omega-3 pufa eicosapentaenoic acid docosahexaenoic acid Biology (General) QH301-705.5 Chemistry QD1-999 |
spellingShingle |
stroke omega-3 pufa eicosapentaenoic acid docosahexaenoic acid Biology (General) QH301-705.5 Chemistry QD1-999 Yuji Ueno Nobukazu Miyamoto Kazuo Yamashiro Ryota Tanaka Nobutaka Hattori Omega-3 Polyunsaturated Fatty Acids and Stroke Burden |
topic_facet |
stroke omega-3 pufa eicosapentaenoic acid docosahexaenoic acid Biology (General) QH301-705.5 Chemistry QD1-999 |
description |
Stroke is a major leading cause of death and disability worldwide. N-3 polyunsaturated fatty acids (PUFAs) including eicosapentaenoic acid and docosahexaenoic acid have potent anti-inflammatory effects, reduce platelet aggregation, and regress atherosclerotic plaques. Since the discovery that the Greenland Eskimo population, whose diet is high in marine n-3 PUFAs, have a lower incidence of coronary heart disease than Western populations, numerous epidemiological studies to explore the associations of dietary intakes of fish and n-3 PUFAs with cardiovascular diseases, and large-scale clinical trials to identify the benefits of treatment with n-3 PUFAs have been conducted. In most of these studies the incidence and mortality of stroke were also evaluated mainly as secondary endpoints. Thus, a systematic literature review regarding the association of dietary intake of n-3 PUFAs with stroke in the epidemiological studies and the treatment effects of n-3 PUFAs in the clinical trials was conducted. Moreover, recent experimental studies were also reviewed to explore the molecular mechanisms of the neuroprotective effects of n-3 PUFAs after stroke. |
format |
Article in Journal/Newspaper |
author |
Yuji Ueno Nobukazu Miyamoto Kazuo Yamashiro Ryota Tanaka Nobutaka Hattori |
author_facet |
Yuji Ueno Nobukazu Miyamoto Kazuo Yamashiro Ryota Tanaka Nobutaka Hattori |
author_sort |
Yuji Ueno |
title |
Omega-3 Polyunsaturated Fatty Acids and Stroke Burden |
title_short |
Omega-3 Polyunsaturated Fatty Acids and Stroke Burden |
title_full |
Omega-3 Polyunsaturated Fatty Acids and Stroke Burden |
title_fullStr |
Omega-3 Polyunsaturated Fatty Acids and Stroke Burden |
title_full_unstemmed |
Omega-3 Polyunsaturated Fatty Acids and Stroke Burden |
title_sort |
omega-3 polyunsaturated fatty acids and stroke burden |
publisher |
MDPI AG |
publishDate |
2019 |
url |
https://doi.org/10.3390/ijms20225549 https://doaj.org/article/2674579c3bcc413499b5be2b8f34d2ae |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland |
genre_facet |
eskimo* Greenland |
op_source |
International Journal of Molecular Sciences, Vol 20, Iss 22, p 5549 (2019) |
op_relation |
https://www.mdpi.com/1422-0067/20/22/5549 https://doaj.org/toc/1422-0067 1422-0067 doi:10.3390/ijms20225549 https://doaj.org/article/2674579c3bcc413499b5be2b8f34d2ae |
op_doi |
https://doi.org/10.3390/ijms20225549 |
container_title |
International Journal of Molecular Sciences |
container_volume |
20 |
container_issue |
22 |
container_start_page |
5549 |
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1766403248881664000 |