Viral Parkinsonism: An underdiagnosed neurological complication of Dengue virus infection.
Dengue virus (DENV) is a flavivirus that is a significant cause of human disease costing billions of dollars per year in medical and mosquito control costs. It is estimated that up to 20% of DENV infections affect the brain. Incidence of DENV infections is increasing, which suggests more people are...
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ftdoajarticles:oai:doaj.org/article:266fb139a4df4492a6f6687feba1e4e9 2023-05-15T15:12:47+02:00 Viral Parkinsonism: An underdiagnosed neurological complication of Dengue virus infection. Hannah K Hopkins Elizabeth M Traverse Kelli L Barr 2022-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010118 https://doaj.org/article/266fb139a4df4492a6f6687feba1e4e9 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010118 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010118 https://doaj.org/article/266fb139a4df4492a6f6687feba1e4e9 PLoS Neglected Tropical Diseases, Vol 16, Iss 2, p e0010118 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010118 2022-12-31T16:06:18Z Dengue virus (DENV) is a flavivirus that is a significant cause of human disease costing billions of dollars per year in medical and mosquito control costs. It is estimated that up to 20% of DENV infections affect the brain. Incidence of DENV infections is increasing, which suggests more people are at risk of developing neurological complications. The most common neurological manifestations of DENV are encephalitis and encephalopathy, and movement disorders such as parkinsonism have been observed. Parkinsonism describes syndromes similar to Parkinson's Disease where tremors, stiffness, and slow movements are observed. Parkinsonism caused by viral infection is characterized by patients exhibiting at least two of the following symptoms: tremor, bradykinesia, rigidity, and postural instability. To investigate DENV-associated parkinsonism, case studies and reports of DENV-associated parkinsonism were obtained from peer-reviewed manuscripts and gray literature. Seven reports of clinically diagnosed DENV-associated parkinsonism and 15 cases of DENV encephalitis, where the patient met the case criteria for a diagnosis of viral parkinsonism were found. Clinically diagnosed DENV-associated parkinsonism patients were more likely to be male and exhibit expressionless face, speech problems, and lymphocytosis. Suspected patients were more likely to exhibit tremor, have thrombocytopenia and low hemoglobin. Viral parkinsonism can cause a permanent reduction in neurons with consequential cognitive and behavior changes, or it can leave a latent imprint in the brain that can cause neurological dysfunction decades after recovery. DENV-associated parkinsonism is underdiagnosed and better adherence to the case definition of viral parkinsonism is needed for proper management of potential sequalae especially if the patient has an ongoing or potential to develop a neurodegenerative disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 2 e0010118 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Hannah K Hopkins Elizabeth M Traverse Kelli L Barr Viral Parkinsonism: An underdiagnosed neurological complication of Dengue virus infection. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Dengue virus (DENV) is a flavivirus that is a significant cause of human disease costing billions of dollars per year in medical and mosquito control costs. It is estimated that up to 20% of DENV infections affect the brain. Incidence of DENV infections is increasing, which suggests more people are at risk of developing neurological complications. The most common neurological manifestations of DENV are encephalitis and encephalopathy, and movement disorders such as parkinsonism have been observed. Parkinsonism describes syndromes similar to Parkinson's Disease where tremors, stiffness, and slow movements are observed. Parkinsonism caused by viral infection is characterized by patients exhibiting at least two of the following symptoms: tremor, bradykinesia, rigidity, and postural instability. To investigate DENV-associated parkinsonism, case studies and reports of DENV-associated parkinsonism were obtained from peer-reviewed manuscripts and gray literature. Seven reports of clinically diagnosed DENV-associated parkinsonism and 15 cases of DENV encephalitis, where the patient met the case criteria for a diagnosis of viral parkinsonism were found. Clinically diagnosed DENV-associated parkinsonism patients were more likely to be male and exhibit expressionless face, speech problems, and lymphocytosis. Suspected patients were more likely to exhibit tremor, have thrombocytopenia and low hemoglobin. Viral parkinsonism can cause a permanent reduction in neurons with consequential cognitive and behavior changes, or it can leave a latent imprint in the brain that can cause neurological dysfunction decades after recovery. DENV-associated parkinsonism is underdiagnosed and better adherence to the case definition of viral parkinsonism is needed for proper management of potential sequalae especially if the patient has an ongoing or potential to develop a neurodegenerative disease. |
format |
Article in Journal/Newspaper |
author |
Hannah K Hopkins Elizabeth M Traverse Kelli L Barr |
author_facet |
Hannah K Hopkins Elizabeth M Traverse Kelli L Barr |
author_sort |
Hannah K Hopkins |
title |
Viral Parkinsonism: An underdiagnosed neurological complication of Dengue virus infection. |
title_short |
Viral Parkinsonism: An underdiagnosed neurological complication of Dengue virus infection. |
title_full |
Viral Parkinsonism: An underdiagnosed neurological complication of Dengue virus infection. |
title_fullStr |
Viral Parkinsonism: An underdiagnosed neurological complication of Dengue virus infection. |
title_full_unstemmed |
Viral Parkinsonism: An underdiagnosed neurological complication of Dengue virus infection. |
title_sort |
viral parkinsonism: an underdiagnosed neurological complication of dengue virus infection. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010118 https://doaj.org/article/266fb139a4df4492a6f6687feba1e4e9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 2, p e0010118 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010118 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010118 https://doaj.org/article/266fb139a4df4492a6f6687feba1e4e9 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010118 |
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PLOS Neglected Tropical Diseases |
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16 |
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2 |
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e0010118 |
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