Pancreatic involvement in fatal human leptospirosis: clinical and histopathological features
Hyperamylasemia has been reported in more than 65% of patients with severe leptospirosis, and the true diagnosis of acute pancreatitis is complicated by the fact that renal failure can increase serum amylase levels. Based on these data we retrospectively analyzed the clinical and histopathological f...
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ftdoajarticles:oai:doaj.org/article:264ad269c06f4599ae90883b8df58b07 2024-09-09T19:26:04+00:00 Pancreatic involvement in fatal human leptospirosis: clinical and histopathological features Daher Elizabeth De Francesco Brunetta Denise Menezes Silva Júnior Geraldo Bezerra da Puster Rainardo Antonio Patrocínio Régia Maria do Socorro Vidal 2003-01-01T00:00:00Z https://doaj.org/article/264ad269c06f4599ae90883b8df58b07 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652003000600002 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/264ad269c06f4599ae90883b8df58b07 Revista do Instituto de Medicina Tropical de São Paulo, Vol 45, Iss 6, Pp 307-313 (2003) Pancreatitis Leptospirosis Acute renal failure Hyperamylasemia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2003 ftdoajarticles 2024-08-05T17:49:30Z Hyperamylasemia has been reported in more than 65% of patients with severe leptospirosis, and the true diagnosis of acute pancreatitis is complicated by the fact that renal failure can increase serum amylase levels. Based on these data we retrospectively analyzed the clinical and histopathological features of pancreas involvement in 13 cases of fatal human leptospirosis. The most common signs and symptoms presented at admission were fever, chills, vomiting, myalgia, dehydratation, abdominal pain and diarrhea. Trombocytopenia was evident in 11 patients. Mild increased of AST and ALT levels was seen in 9 patients. Hyperamylasemia was recorded in every patient in whom it was measured, with values above 180 IU/L (3 cases). All patients presented acute renal failure and five have been submitted to dialytic treatment. The main cause of death was acute respiratory failure due to pulmonary hemorrhage. Pancreas fragments were collected for histological study and fat necrosis was the criterion used to classify acute pancreatitis. Histological pancreatic findings were edema, mild inflammatory infiltrate of lymphocytes, hemorrhage, congestion, fat necrosis and calcification. All the patients infected with severe form of leptospirosis who develop abdominal pain should raise the suspect of pancreatic involvement. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Pancreatitis Leptospirosis Acute renal failure Hyperamylasemia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Pancreatitis Leptospirosis Acute renal failure Hyperamylasemia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Daher Elizabeth De Francesco Brunetta Denise Menezes Silva Júnior Geraldo Bezerra da Puster Rainardo Antonio Patrocínio Régia Maria do Socorro Vidal Pancreatic involvement in fatal human leptospirosis: clinical and histopathological features |
topic_facet |
Pancreatitis Leptospirosis Acute renal failure Hyperamylasemia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Hyperamylasemia has been reported in more than 65% of patients with severe leptospirosis, and the true diagnosis of acute pancreatitis is complicated by the fact that renal failure can increase serum amylase levels. Based on these data we retrospectively analyzed the clinical and histopathological features of pancreas involvement in 13 cases of fatal human leptospirosis. The most common signs and symptoms presented at admission were fever, chills, vomiting, myalgia, dehydratation, abdominal pain and diarrhea. Trombocytopenia was evident in 11 patients. Mild increased of AST and ALT levels was seen in 9 patients. Hyperamylasemia was recorded in every patient in whom it was measured, with values above 180 IU/L (3 cases). All patients presented acute renal failure and five have been submitted to dialytic treatment. The main cause of death was acute respiratory failure due to pulmonary hemorrhage. Pancreas fragments were collected for histological study and fat necrosis was the criterion used to classify acute pancreatitis. Histological pancreatic findings were edema, mild inflammatory infiltrate of lymphocytes, hemorrhage, congestion, fat necrosis and calcification. All the patients infected with severe form of leptospirosis who develop abdominal pain should raise the suspect of pancreatic involvement. |
format |
Article in Journal/Newspaper |
author |
Daher Elizabeth De Francesco Brunetta Denise Menezes Silva Júnior Geraldo Bezerra da Puster Rainardo Antonio Patrocínio Régia Maria do Socorro Vidal |
author_facet |
Daher Elizabeth De Francesco Brunetta Denise Menezes Silva Júnior Geraldo Bezerra da Puster Rainardo Antonio Patrocínio Régia Maria do Socorro Vidal |
author_sort |
Daher Elizabeth De Francesco |
title |
Pancreatic involvement in fatal human leptospirosis: clinical and histopathological features |
title_short |
Pancreatic involvement in fatal human leptospirosis: clinical and histopathological features |
title_full |
Pancreatic involvement in fatal human leptospirosis: clinical and histopathological features |
title_fullStr |
Pancreatic involvement in fatal human leptospirosis: clinical and histopathological features |
title_full_unstemmed |
Pancreatic involvement in fatal human leptospirosis: clinical and histopathological features |
title_sort |
pancreatic involvement in fatal human leptospirosis: clinical and histopathological features |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2003 |
url |
https://doaj.org/article/264ad269c06f4599ae90883b8df58b07 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 45, Iss 6, Pp 307-313 (2003) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652003000600002 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/264ad269c06f4599ae90883b8df58b07 |
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1809895756421660672 |