Ethnobotanic study of Randia aculeata (Rubiaceae) in Jamapa, Veracruz, Mexico, and its anti-snake venom effects on mouse tissue
In Mexico, medicinal plants are widely used. The use of Randia aculeata by healers against snakebites has never been scientifically tested in relation to possible effects on blood parameters and muscle tissue damage. Interviews were carried out in Jamapa, Veracuz, Mexico, with local residents to col...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:263a05ab4e644789aa52b074bd4391cd 2023-05-15T15:09:40+02:00 Ethnobotanic study of Randia aculeata (Rubiaceae) in Jamapa, Veracruz, Mexico, and its anti-snake venom effects on mouse tissue CA Gallardo-Casas G Guevara-Balcázar E Morales-Ramos Y Tadeo-Jiménez O Gutiérrez-Flores N Jiménez-Sánchez MT Valadez-Omaña MT Valenzuela-Vargas MC Castillo-Hernández 2012-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992012000300006 https://doaj.org/article/263a05ab4e644789aa52b074bd4391cd EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000300006 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992012000300006 1678-9199 https://doaj.org/article/263a05ab4e644789aa52b074bd4391cd Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 18, Iss 3, Pp 287-294 (2012) Rubiaceae antivenoms Bothrops Crotalus cytoprotection Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2012 ftdoajarticles https://doi.org/10.1590/S1678-91992012000300006 2022-12-31T15:48:43Z In Mexico, medicinal plants are widely used. The use of Randia aculeata by healers against snakebites has never been scientifically tested in relation to possible effects on blood parameters and muscle tissue damage. Interviews were carried out in Jamapa, Veracuz, Mexico, with local residents to collect information about the traditional use of Randia aculeata. In this locality, seven pieces of fruit from the plant are mixed in a liter of alcohol, and then administered orally against snakebites. By using histological techniques and a murine model, we explored its cytoprotective properties against the effects of Crotalus simus and Bothrops asper venoms. Possible protections provided by the plant against tissue damage to skeletal and cardiac muscles and against the typical loss of red blood cells were analyzed. Randia aculeata caused an increase in microhematocrit and total hemoglobin, parameters that are often decremented in association with the loss of red blood cells, which is a characteristic effect of animal venom. Randia aculeata was also shown to protect against the lowering of platelet levels caused by Bothrops asper venom. Finally, Randia aculeata produced a partial inhibition of necrosis following administration of snake venom in skeletal and myocardial muscles. The present results provide solid evidence for the traditional use of Randia aculeata against snakebites, as demonstrated by protection against muscular tissue damage and the diminution of red blood cells. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 18 3 287 294 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Rubiaceae antivenoms Bothrops Crotalus cytoprotection Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Rubiaceae antivenoms Bothrops Crotalus cytoprotection Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 CA Gallardo-Casas G Guevara-Balcázar E Morales-Ramos Y Tadeo-Jiménez O Gutiérrez-Flores N Jiménez-Sánchez MT Valadez-Omaña MT Valenzuela-Vargas MC Castillo-Hernández Ethnobotanic study of Randia aculeata (Rubiaceae) in Jamapa, Veracruz, Mexico, and its anti-snake venom effects on mouse tissue |
topic_facet |
Rubiaceae antivenoms Bothrops Crotalus cytoprotection Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
In Mexico, medicinal plants are widely used. The use of Randia aculeata by healers against snakebites has never been scientifically tested in relation to possible effects on blood parameters and muscle tissue damage. Interviews were carried out in Jamapa, Veracuz, Mexico, with local residents to collect information about the traditional use of Randia aculeata. In this locality, seven pieces of fruit from the plant are mixed in a liter of alcohol, and then administered orally against snakebites. By using histological techniques and a murine model, we explored its cytoprotective properties against the effects of Crotalus simus and Bothrops asper venoms. Possible protections provided by the plant against tissue damage to skeletal and cardiac muscles and against the typical loss of red blood cells were analyzed. Randia aculeata caused an increase in microhematocrit and total hemoglobin, parameters that are often decremented in association with the loss of red blood cells, which is a characteristic effect of animal venom. Randia aculeata was also shown to protect against the lowering of platelet levels caused by Bothrops asper venom. Finally, Randia aculeata produced a partial inhibition of necrosis following administration of snake venom in skeletal and myocardial muscles. The present results provide solid evidence for the traditional use of Randia aculeata against snakebites, as demonstrated by protection against muscular tissue damage and the diminution of red blood cells. |
format |
Article in Journal/Newspaper |
author |
CA Gallardo-Casas G Guevara-Balcázar E Morales-Ramos Y Tadeo-Jiménez O Gutiérrez-Flores N Jiménez-Sánchez MT Valadez-Omaña MT Valenzuela-Vargas MC Castillo-Hernández |
author_facet |
CA Gallardo-Casas G Guevara-Balcázar E Morales-Ramos Y Tadeo-Jiménez O Gutiérrez-Flores N Jiménez-Sánchez MT Valadez-Omaña MT Valenzuela-Vargas MC Castillo-Hernández |
author_sort |
CA Gallardo-Casas |
title |
Ethnobotanic study of Randia aculeata (Rubiaceae) in Jamapa, Veracruz, Mexico, and its anti-snake venom effects on mouse tissue |
title_short |
Ethnobotanic study of Randia aculeata (Rubiaceae) in Jamapa, Veracruz, Mexico, and its anti-snake venom effects on mouse tissue |
title_full |
Ethnobotanic study of Randia aculeata (Rubiaceae) in Jamapa, Veracruz, Mexico, and its anti-snake venom effects on mouse tissue |
title_fullStr |
Ethnobotanic study of Randia aculeata (Rubiaceae) in Jamapa, Veracruz, Mexico, and its anti-snake venom effects on mouse tissue |
title_full_unstemmed |
Ethnobotanic study of Randia aculeata (Rubiaceae) in Jamapa, Veracruz, Mexico, and its anti-snake venom effects on mouse tissue |
title_sort |
ethnobotanic study of randia aculeata (rubiaceae) in jamapa, veracruz, mexico, and its anti-snake venom effects on mouse tissue |
publisher |
SciELO |
publishDate |
2012 |
url |
https://doi.org/10.1590/S1678-91992012000300006 https://doaj.org/article/263a05ab4e644789aa52b074bd4391cd |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 18, Iss 3, Pp 287-294 (2012) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000300006 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992012000300006 1678-9199 https://doaj.org/article/263a05ab4e644789aa52b074bd4391cd |
op_doi |
https://doi.org/10.1590/S1678-91992012000300006 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
18 |
container_issue |
3 |
container_start_page |
287 |
op_container_end_page |
294 |
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1766340820626046976 |