Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic Response.
Thromboembolic events were described in patients with Chagas disease without cardiomyopathy. We aim to confirm if there is a hypercoagulable state in these patients and to determine if there is an early normalization of hemostasis factors after antiparasitic treatment. Ninety-nine individuals from C...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0004269 https://doaj.org/article/2637f91cabf242139b92923e643da228 |
id |
ftdoajarticles:oai:doaj.org/article:2637f91cabf242139b92923e643da228 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:2637f91cabf242139b92923e643da228 2023-05-15T15:09:32+02:00 Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic Response. Maria-Jesus Pinazo Elizabeth de Jesus Posada Luis Izquierdo Dolors Tassies Alexandre-Ferreira Marques Elisa de Lazzari Edelweiss Aldasoro Jose Muñoz Alba Abras Silvia Tebar Montserrat Gallego Igor Correia de Almeida Joan-Carles Reverter Joaquim Gascon 2016-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004269 https://doaj.org/article/2637f91cabf242139b92923e643da228 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4700971?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004269 https://doaj.org/article/2637f91cabf242139b92923e643da228 PLoS Neglected Tropical Diseases, Vol 10, Iss 1, p e0004269 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004269 2022-12-31T11:08:10Z Thromboembolic events were described in patients with Chagas disease without cardiomyopathy. We aim to confirm if there is a hypercoagulable state in these patients and to determine if there is an early normalization of hemostasis factors after antiparasitic treatment. Ninety-nine individuals from Chagas disease-endemic areas were classified in two groups: G1, with T.cruzi infection (n = 56); G2, healthy individuals (n = 43). Twenty-four hemostasis factors were measured at baseline. G1 patients treated with benznidazole were followed for 36 months, recording clinical parameters and performance of conventional serology, chemiluminescent enzyme-linked immunosorbent assay (trypomastigote-derived glycosylphosphatidylinositol-anchored mucins), quantitative polymerase chain reaction, and hemostasis tests every 6-month visits. Prothrombin fragment 1+2 (F1+2) and endogenous thrombin potential (ETP) were abnormally expressed in 77% and 50% of infected patients at baseline but returned to and remained at normal levels shortly after treatment in 76% and 96% of cases, respectively. Plasmin-antiplasmin complexes (PAP) were altered before treatment in 32% of G1 patients but normalized in 94% of cases several months after treatment. None of the patients with normal F1+2 values during follow-up had a positive qRT-PCR result, but 3/24 patients (13%) with normal ETP values did. In a percentage of chronic T. cruzi infected patients treated with benznidazole, altered coagulation markers returned into normal levels. F1+2, ETP and PAP could be useful markers for assessing sustained response to benznidazole. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 1 e0004269 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Maria-Jesus Pinazo Elizabeth de Jesus Posada Luis Izquierdo Dolors Tassies Alexandre-Ferreira Marques Elisa de Lazzari Edelweiss Aldasoro Jose Muñoz Alba Abras Silvia Tebar Montserrat Gallego Igor Correia de Almeida Joan-Carles Reverter Joaquim Gascon Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic Response. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Thromboembolic events were described in patients with Chagas disease without cardiomyopathy. We aim to confirm if there is a hypercoagulable state in these patients and to determine if there is an early normalization of hemostasis factors after antiparasitic treatment. Ninety-nine individuals from Chagas disease-endemic areas were classified in two groups: G1, with T.cruzi infection (n = 56); G2, healthy individuals (n = 43). Twenty-four hemostasis factors were measured at baseline. G1 patients treated with benznidazole were followed for 36 months, recording clinical parameters and performance of conventional serology, chemiluminescent enzyme-linked immunosorbent assay (trypomastigote-derived glycosylphosphatidylinositol-anchored mucins), quantitative polymerase chain reaction, and hemostasis tests every 6-month visits. Prothrombin fragment 1+2 (F1+2) and endogenous thrombin potential (ETP) were abnormally expressed in 77% and 50% of infected patients at baseline but returned to and remained at normal levels shortly after treatment in 76% and 96% of cases, respectively. Plasmin-antiplasmin complexes (PAP) were altered before treatment in 32% of G1 patients but normalized in 94% of cases several months after treatment. None of the patients with normal F1+2 values during follow-up had a positive qRT-PCR result, but 3/24 patients (13%) with normal ETP values did. In a percentage of chronic T. cruzi infected patients treated with benznidazole, altered coagulation markers returned into normal levels. F1+2, ETP and PAP could be useful markers for assessing sustained response to benznidazole. |
format |
Article in Journal/Newspaper |
author |
Maria-Jesus Pinazo Elizabeth de Jesus Posada Luis Izquierdo Dolors Tassies Alexandre-Ferreira Marques Elisa de Lazzari Edelweiss Aldasoro Jose Muñoz Alba Abras Silvia Tebar Montserrat Gallego Igor Correia de Almeida Joan-Carles Reverter Joaquim Gascon |
author_facet |
Maria-Jesus Pinazo Elizabeth de Jesus Posada Luis Izquierdo Dolors Tassies Alexandre-Ferreira Marques Elisa de Lazzari Edelweiss Aldasoro Jose Muñoz Alba Abras Silvia Tebar Montserrat Gallego Igor Correia de Almeida Joan-Carles Reverter Joaquim Gascon |
author_sort |
Maria-Jesus Pinazo |
title |
Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic Response. |
title_short |
Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic Response. |
title_full |
Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic Response. |
title_fullStr |
Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic Response. |
title_full_unstemmed |
Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic Response. |
title_sort |
altered hypercoagulability factors in patients with chronic chagas disease: potential biomarkers of therapeutic response. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004269 https://doaj.org/article/2637f91cabf242139b92923e643da228 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 1, p e0004269 (2016) |
op_relation |
http://europepmc.org/articles/PMC4700971?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004269 https://doaj.org/article/2637f91cabf242139b92923e643da228 |
op_doi |
https://doi.org/10.1371/journal.pntd.0004269 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
10 |
container_issue |
1 |
container_start_page |
e0004269 |
_version_ |
1766340717210238976 |