SIMULATION OF EPIDEMIC TRANSMISSION OF МYCOBACTERIUM TUBERCULOSIS IN THE SAKHA REPUBLIC (YUKUTIA )

• Published in: Tuberculosis and Lung Diseases
• Main Authors: S. N. Zhdаnovа, O. B. Ogаrkov, M. K. Vinokurovа, G. I. Аlekseevа, A. F. Krаvchenko, E. D. Sаvilov
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: New Terra Publishing House 2017
• Subjects: m. tuberculosis; miru-vntr; эпидемические генотипы; beijing; Diseases of the respiratory system; RC705-779; Sakha; Sakha Republic; Yakutia
• Online Access: https://doi.org/10.21292/2075-1230-2017-95-7-40-47; https://doaj.org/article/26159a3ad0e8489b9f4af5cd530b9754

Goal: reconstruction of epidemic transmission of Beijing genotype of Mycobacterium tuberculosis on the territory with limited migration based on the comparative study of 153 isolates isolated from patients of different generations in theSakhaRepublic (Yakutia).Materials and methods. The structure of Mycobacterium tuberculosis population was described and analyzed through MIRU-VNTR-genotyping, subtyping of the parts of RD105/RD207 genome, pattern classification as per clonal pattern of Merker M. et al (2015), and phylogenetic simulation.Results. It was found out that highly transmissive subtypes of Beijing genotype having a high potential of developing drug resistance was confidently more prevalent (χ2 = 8.3, p < 0.01) among younger people (born after 1990) compared to the older generation (born before 1959). It was also found out that during previous five decades a certain shift occurred in the structure of M. tuberculosis population.Conclusion. The obtained data confirm the hypothesis that epidemic sybtypes ofBeijing genotype were brought to the territory of theSakhaRepublic (Yakutia) fairly recently (approximately fifty years ago) compared to the other regions ofRussia.