The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995–2005

Abstract Background The use of genotyping to distinguish recrudescent from new infections is currently recommended for all clinical antimalarial efficacy trials by the World Health Organization. However, genotyping-adjusted drug efficacy estimates may vary between trials due to the use of different...

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Published in:Malaria Journal
Main Authors: Rosenthal Philip J, Greenhouse Bryan, Collins William J, Dorsey Grant
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2006
Subjects:
Online Access:https://doi.org/10.1186/1475-2875-5-122
https://doaj.org/article/25e18567c74b4a1093bbf07067f58bfe
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spelling ftdoajarticles:oai:doaj.org/article:25e18567c74b4a1093bbf07067f58bfe 2023-05-15T15:05:59+02:00 The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995–2005 Rosenthal Philip J Greenhouse Bryan Collins William J Dorsey Grant 2006-12-01T00:00:00Z https://doi.org/10.1186/1475-2875-5-122 https://doaj.org/article/25e18567c74b4a1093bbf07067f58bfe EN eng BMC http://www.malariajournal.com/content/5/1/122 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-5-122 1475-2875 https://doaj.org/article/25e18567c74b4a1093bbf07067f58bfe Malaria Journal, Vol 5, Iss 1, p 122 (2006) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2006 ftdoajarticles https://doi.org/10.1186/1475-2875-5-122 2022-12-31T13:49:32Z Abstract Background The use of genotyping to distinguish recrudescent from new infections is currently recommended for all clinical antimalarial efficacy trials by the World Health Organization. However, genotyping-adjusted drug efficacy estimates may vary between trials due to the use of different genotyping methods and to the different settings in which these methods are applied. Methods A systematic review of all clinical antimalarial efficacy trials published from 1995–2005 was performed to characterize the use of genotyping, including the methods used and the effect of these methods on estimates of drug efficacy. Results In a multivariate analysis, the method of interpretation of genotyping results, the studied therapy, the location of the trial, and the duration of study follow-up all had statistically significant effects on the percent of genotyped outcomes classified as new infections. Conclusion Criteria for defining appropriate, standardized genotyping methods for use in different settings are needed to enable more accurate estimates of antimalarial drug efficacy and better comparison between trials. The advantages and disadvantages of different genotyping methods and their potential impact in various settings are discussed. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 5 1 122
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
spellingShingle Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Rosenthal Philip J
Greenhouse Bryan
Collins William J
Dorsey Grant
The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995–2005
topic_facet Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
description Abstract Background The use of genotyping to distinguish recrudescent from new infections is currently recommended for all clinical antimalarial efficacy trials by the World Health Organization. However, genotyping-adjusted drug efficacy estimates may vary between trials due to the use of different genotyping methods and to the different settings in which these methods are applied. Methods A systematic review of all clinical antimalarial efficacy trials published from 1995–2005 was performed to characterize the use of genotyping, including the methods used and the effect of these methods on estimates of drug efficacy. Results In a multivariate analysis, the method of interpretation of genotyping results, the studied therapy, the location of the trial, and the duration of study follow-up all had statistically significant effects on the percent of genotyped outcomes classified as new infections. Conclusion Criteria for defining appropriate, standardized genotyping methods for use in different settings are needed to enable more accurate estimates of antimalarial drug efficacy and better comparison between trials. The advantages and disadvantages of different genotyping methods and their potential impact in various settings are discussed.
format Article in Journal/Newspaper
author Rosenthal Philip J
Greenhouse Bryan
Collins William J
Dorsey Grant
author_facet Rosenthal Philip J
Greenhouse Bryan
Collins William J
Dorsey Grant
author_sort Rosenthal Philip J
title The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995–2005
title_short The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995–2005
title_full The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995–2005
title_fullStr The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995–2005
title_full_unstemmed The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995–2005
title_sort use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995–2005
publisher BMC
publishDate 2006
url https://doi.org/10.1186/1475-2875-5-122
https://doaj.org/article/25e18567c74b4a1093bbf07067f58bfe
geographic Arctic
geographic_facet Arctic
genre Arctic
genre_facet Arctic
op_source Malaria Journal, Vol 5, Iss 1, p 122 (2006)
op_relation http://www.malariajournal.com/content/5/1/122
https://doaj.org/toc/1475-2875
doi:10.1186/1475-2875-5-122
1475-2875
https://doaj.org/article/25e18567c74b4a1093bbf07067f58bfe
op_doi https://doi.org/10.1186/1475-2875-5-122
container_title Malaria Journal
container_volume 5
container_issue 1
container_start_page 122
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