Zika virus congenital syndrome: experimental models and clinical aspects
Abstract Viral infections have long been the cause of severe diseases to humans, increasing morbidity and mortality rates worldwide, either in rich or poor countries. Yellow fever virus, H1N1 virus, HIV, dengue virus, hepatitis B and C are well known threats to human health, being responsible for ma...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:254ccd598888443793ec6b0ccedd398f 2023-05-15T15:09:45+02:00 Zika virus congenital syndrome: experimental models and clinical aspects Carolina Manganeli Polonio Carla Longo de Freitas Nagela Ghabdan Zanluqui Jean Pierre Schatzmann Peron 2017-09-01T00:00:00Z https://doi.org/10.1186/s40409-017-0131-x https://doaj.org/article/254ccd598888443793ec6b0ccedd398f EN eng SciELO http://link.springer.com/article/10.1186/s40409-017-0131-x https://doaj.org/toc/1678-9199 doi:10.1186/s40409-017-0131-x 1678-9199 https://doaj.org/article/254ccd598888443793ec6b0ccedd398f Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 23, Iss 1, Pp 1-9 (2017) Zika virus Congenital infection Arthrogryposis Ocular abnormality Experimental models Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2017 ftdoajarticles https://doi.org/10.1186/s40409-017-0131-x 2022-12-31T09:08:52Z Abstract Viral infections have long been the cause of severe diseases to humans, increasing morbidity and mortality rates worldwide, either in rich or poor countries. Yellow fever virus, H1N1 virus, HIV, dengue virus, hepatitis B and C are well known threats to human health, being responsible for many million deaths annually, associated to a huge economic and social cost. In this context, a recently introduced flavivirus in South America, called Zika virus (ZIKV), led the WHO to declare in February 1st 2016 a warning on Public Health Emergency of International Concern (PHEIC). ZIKV is an arbovirus of the Flaviviridae family firstly isolated from sentinels Rhesus sp. monkeys at the Ziika forest in Uganda, Africa, in 1947. Lately, the virus has well adapted to the worldwide spread Aedes aegypti mosquito, the vector for DENV, CHIKV, YFV and many others. At first, it was not considered a threat to human health, but everything changed when a skyrocketing number of babies born with microcephaly and adults with Guillain-Barré syndrome were reported, mainly in northeastern Brazil. It is now well established that the virus is responsible for the so called congenital Zika syndrome (CZS), whose most dramatic features are microcephaly, arthrogryposis and ocular damage. Thus, in this review, we provide a brief discussion of these main clinical aspects of the CZS, correlating them with the experimental animal models described so far. Article in Journal/Newspaper Arctic Human health Directory of Open Access Journals: DOAJ Articles Arctic Barré ENVELOPE(-68.550,-68.550,-67.500,-67.500) Journal of Venomous Animals and Toxins including Tropical Diseases 23 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Zika virus Congenital infection Arthrogryposis Ocular abnormality Experimental models Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Zika virus Congenital infection Arthrogryposis Ocular abnormality Experimental models Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Carolina Manganeli Polonio Carla Longo de Freitas Nagela Ghabdan Zanluqui Jean Pierre Schatzmann Peron Zika virus congenital syndrome: experimental models and clinical aspects |
topic_facet |
Zika virus Congenital infection Arthrogryposis Ocular abnormality Experimental models Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract Viral infections have long been the cause of severe diseases to humans, increasing morbidity and mortality rates worldwide, either in rich or poor countries. Yellow fever virus, H1N1 virus, HIV, dengue virus, hepatitis B and C are well known threats to human health, being responsible for many million deaths annually, associated to a huge economic and social cost. In this context, a recently introduced flavivirus in South America, called Zika virus (ZIKV), led the WHO to declare in February 1st 2016 a warning on Public Health Emergency of International Concern (PHEIC). ZIKV is an arbovirus of the Flaviviridae family firstly isolated from sentinels Rhesus sp. monkeys at the Ziika forest in Uganda, Africa, in 1947. Lately, the virus has well adapted to the worldwide spread Aedes aegypti mosquito, the vector for DENV, CHIKV, YFV and many others. At first, it was not considered a threat to human health, but everything changed when a skyrocketing number of babies born with microcephaly and adults with Guillain-Barré syndrome were reported, mainly in northeastern Brazil. It is now well established that the virus is responsible for the so called congenital Zika syndrome (CZS), whose most dramatic features are microcephaly, arthrogryposis and ocular damage. Thus, in this review, we provide a brief discussion of these main clinical aspects of the CZS, correlating them with the experimental animal models described so far. |
format |
Article in Journal/Newspaper |
author |
Carolina Manganeli Polonio Carla Longo de Freitas Nagela Ghabdan Zanluqui Jean Pierre Schatzmann Peron |
author_facet |
Carolina Manganeli Polonio Carla Longo de Freitas Nagela Ghabdan Zanluqui Jean Pierre Schatzmann Peron |
author_sort |
Carolina Manganeli Polonio |
title |
Zika virus congenital syndrome: experimental models and clinical aspects |
title_short |
Zika virus congenital syndrome: experimental models and clinical aspects |
title_full |
Zika virus congenital syndrome: experimental models and clinical aspects |
title_fullStr |
Zika virus congenital syndrome: experimental models and clinical aspects |
title_full_unstemmed |
Zika virus congenital syndrome: experimental models and clinical aspects |
title_sort |
zika virus congenital syndrome: experimental models and clinical aspects |
publisher |
SciELO |
publishDate |
2017 |
url |
https://doi.org/10.1186/s40409-017-0131-x https://doaj.org/article/254ccd598888443793ec6b0ccedd398f |
long_lat |
ENVELOPE(-68.550,-68.550,-67.500,-67.500) |
geographic |
Arctic Barré |
geographic_facet |
Arctic Barré |
genre |
Arctic Human health |
genre_facet |
Arctic Human health |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 23, Iss 1, Pp 1-9 (2017) |
op_relation |
http://link.springer.com/article/10.1186/s40409-017-0131-x https://doaj.org/toc/1678-9199 doi:10.1186/s40409-017-0131-x 1678-9199 https://doaj.org/article/254ccd598888443793ec6b0ccedd398f |
op_doi |
https://doi.org/10.1186/s40409-017-0131-x |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
23 |
container_issue |
1 |
_version_ |
1766340884210647040 |