Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis?
Objective. Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease. This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with...
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ftdoajarticles:oai:doaj.org/article:2547561fa1c9435ba2cb470cd904b181 2023-05-15T17:44:44+02:00 Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis? Anna Södergren Kjell Karp Christine Bengtsson Bozena Möller Solbritt Rantapää-Dahlqvist Solveig Wållberg-Jonsson 2015-01-01T00:00:00Z https://doi.org/10.1155/2015/673018 https://doaj.org/article/2547561fa1c9435ba2cb470cd904b181 EN eng Hindawi Limited http://dx.doi.org/10.1155/2015/673018 https://doaj.org/toc/2314-6133 https://doaj.org/toc/2314-6141 2314-6133 2314-6141 doi:10.1155/2015/673018 https://doaj.org/article/2547561fa1c9435ba2cb470cd904b181 BioMed Research International, Vol 2015 (2015) Medicine R article 2015 ftdoajarticles https://doi.org/10.1155/2015/673018 2022-12-31T14:35:40Z Objective. Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease. This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis (RA). Methods. Patients from northern Sweden diagnosed with early RA were consecutively recruited into an ongoing prospective study. From these, all patients ≤60 years (n=71) were included for measurements of subclinical atherosclerosis at inclusion (T0) and five years later (T5). Forty age- and sex-matched controls were included. The patients were clinically assessed, SCORE, Reynolds Risk Score, and Larsen score were calculated, and blood samples were drawn from all individuals at T0 and T5. Results. There was no significant difference in the level of Lp-PLA2 between patients with RA and controls (p>0.05). In simple linear regression models among patients with RA, Lp-PLA2 at T0 was significantly associated with intima media thickness (IMT) at T0 and T5, flow mediated dilation (FMD) at T0 and T5, ever smoking, male sex, HDL-cholesterol (inversely), non-HDL-cholesterol, SCORE, Reynolds Risk Score, and Larsen score (p<0.05). Conclusion. In this cohort of patients with early RA, the concentration of Lp-PLA2 was associated with both subclinical atherosclerosis and disease severity. Article in Journal/Newspaper Northern Sweden Directory of Open Access Journals: DOAJ Articles BioMed Research International 2015 1 7 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
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language |
English |
topic |
Medicine R |
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Medicine R Anna Södergren Kjell Karp Christine Bengtsson Bozena Möller Solbritt Rantapää-Dahlqvist Solveig Wållberg-Jonsson Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis? |
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Medicine R |
description |
Objective. Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease. This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis (RA). Methods. Patients from northern Sweden diagnosed with early RA were consecutively recruited into an ongoing prospective study. From these, all patients ≤60 years (n=71) were included for measurements of subclinical atherosclerosis at inclusion (T0) and five years later (T5). Forty age- and sex-matched controls were included. The patients were clinically assessed, SCORE, Reynolds Risk Score, and Larsen score were calculated, and blood samples were drawn from all individuals at T0 and T5. Results. There was no significant difference in the level of Lp-PLA2 between patients with RA and controls (p>0.05). In simple linear regression models among patients with RA, Lp-PLA2 at T0 was significantly associated with intima media thickness (IMT) at T0 and T5, flow mediated dilation (FMD) at T0 and T5, ever smoking, male sex, HDL-cholesterol (inversely), non-HDL-cholesterol, SCORE, Reynolds Risk Score, and Larsen score (p<0.05). Conclusion. In this cohort of patients with early RA, the concentration of Lp-PLA2 was associated with both subclinical atherosclerosis and disease severity. |
format |
Article in Journal/Newspaper |
author |
Anna Södergren Kjell Karp Christine Bengtsson Bozena Möller Solbritt Rantapää-Dahlqvist Solveig Wållberg-Jonsson |
author_facet |
Anna Södergren Kjell Karp Christine Bengtsson Bozena Möller Solbritt Rantapää-Dahlqvist Solveig Wållberg-Jonsson |
author_sort |
Anna Södergren |
title |
Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis? |
title_short |
Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis? |
title_full |
Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis? |
title_fullStr |
Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis? |
title_full_unstemmed |
Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis? |
title_sort |
is lipoprotein-associated phospholipase a2 a link between inflammation and subclinical atherosclerosis in rheumatoid arthritis? |
publisher |
Hindawi Limited |
publishDate |
2015 |
url |
https://doi.org/10.1155/2015/673018 https://doaj.org/article/2547561fa1c9435ba2cb470cd904b181 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
BioMed Research International, Vol 2015 (2015) |
op_relation |
http://dx.doi.org/10.1155/2015/673018 https://doaj.org/toc/2314-6133 https://doaj.org/toc/2314-6141 2314-6133 2314-6141 doi:10.1155/2015/673018 https://doaj.org/article/2547561fa1c9435ba2cb470cd904b181 |
op_doi |
https://doi.org/10.1155/2015/673018 |
container_title |
BioMed Research International |
container_volume |
2015 |
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1 |
op_container_end_page |
7 |
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1766147019978571776 |