Different evolutionary dynamics of hepatitis B virus genotypes A and D, and hepatitis D virus genotypes 1 and 2 in an endemic area of Yakutia, Russia

• Published in: BMC Infectious Diseases
• Main Authors: Anastasia A. Karlsen, Karen K. Kyuregyan, Olga V. Isaeva, Vera S. Kichatova, Fedor A. Asadi Mobarkhan, Lyudmila V. Bezuglova, Irina G. Netesova, Victor A. Manuylov, Andrey A. Pochtovyi, Vladimir A. Gushchin, Snezhana S. Sleptsova, Margarita E. Ignateva, Mikhail I. Mikhailov
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2022
• Subjects: Hepatitis B virus; Hepatitis delta virus; Viral genotypes; Vaccination; Phylodynamics; Evolutionary dynamics; Infectious and parasitic diseases; RC109-216; Yakutia
• Online Access: https://doi.org/10.1186/s12879-022-07444-w; https://doaj.org/article/2534001ebd934264b6c1834edaea2c71

Abstract Background The geographic distribution of the hepatitis B virus (HBV) and the hepatitis D virus (HDV) genotypes is uneven. We reconstructed the temporal evolution of HBV and HDV in Yakutia, one of the regions of Russia most affected by HBV and HDV, in an attempt to understand the possible mechanisms that led to unusual for Russia pattern of viral genotypes and to identify current distribution trends. Methods HBV and HDV genotypes were determined in sera collected in 2018–2019 in Yakutia from randomly selected 140 patients with HBV monoinfection and 59 patients with HBV/HDV. Total 86 HBV and 88 HDV genomic sequences isolated in Yakutia between 1997 and 2019 were subjected to phylodynamic and philogeographic Bayesian analysis using BEAST v1.10.4 software package. Bayesian SkyGrid reconstruction and Birth–Death Skyline analysis were applied to estimate HBV and HDV population dynamics. Results Currently, HBV-A and HDV-D genotypes are prevalent in Yakutia, in both monoinfected and HDV-coinfected patients. Bayesian analysis has shown that the high prevalence of HBV-A in Yakutia, which is not typical for Russia, initially emerged after the genotype was introduced from Eastern Europe in the fifteenth century (around 600 (95% HPD: 50–715) years ago). The acute hepatitis B epidemics in the 1990s in Yakutia were largely associated with this particular genotype, as indicated by temporal changes in HBV-A population dynamics. HBV-D had a longer history in Yakutia and demonstrated stable population dynamics, indicating ongoing viral circulation despite vaccination. No correlation between HBV and HDV genotypes was observed for coinfected patients in Yakutia (r = − 0.016069332). HDV-2b circulates in Russia in Yakutia only and resulted from a single wave of introduction from Central Asia 135 years ago (95% HPD: 60–350 years), while HDV-1 strains resulted from multiple introductions from Europe, the Middle East, Central Asia, and different parts of Russia starting 180 years ago (95% HPD: 150–210 years) and continuing to ...