Congenital Rift Valley fever in Sprague Dawley rats is associated with diffuse infection and pathology of the placenta.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Cynthia M McMillen, Devin A Boyles, Stefan G Kostadinov, Ryan M Hoehl, Madeline M Schwarz, Joseph R Albe, Matthew J Demers, Amy L Hartman
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2022
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Labyrinth
• Online Access: https://doi.org/10.1371/journal.pntd.0010898; https://doaj.org/article/252dffdec9d24454814de48ee8408d52

Rift Valley fever (RVF) is a disease of animals and humans associated with abortions in ruminants and late-gestation miscarriages in women. Here, we use a rat model of congenital RVF to identify tropisms, pathologies, and immune responses in the placenta during vertical transmission. Infection of la...