Congenital Rift Valley fever in Sprague Dawley rats is associated with diffuse infection and pathology of the placenta.
Rift Valley fever (RVF) is a disease of animals and humans associated with abortions in ruminants and late-gestation miscarriages in women. Here, we use a rat model of congenital RVF to identify tropisms, pathologies, and immune responses in the placenta during vertical transmission. Infection of la...
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ftdoajarticles:oai:doaj.org/article:252dffdec9d24454814de48ee8408d52 2023-07-16T03:56:58+02:00 Congenital Rift Valley fever in Sprague Dawley rats is associated with diffuse infection and pathology of the placenta. Cynthia M McMillen Devin A Boyles Stefan G Kostadinov Ryan M Hoehl Madeline M Schwarz Joseph R Albe Matthew J Demers Amy L Hartman 2022-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010898 https://doaj.org/article/252dffdec9d24454814de48ee8408d52 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010898 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010898 https://doaj.org/article/252dffdec9d24454814de48ee8408d52 PLoS Neglected Tropical Diseases, Vol 16, Iss 10, p e0010898 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010898 2023-06-25T00:36:01Z Rift Valley fever (RVF) is a disease of animals and humans associated with abortions in ruminants and late-gestation miscarriages in women. Here, we use a rat model of congenital RVF to identify tropisms, pathologies, and immune responses in the placenta during vertical transmission. Infection of late-gestation pregnant rats resulted in vertical transmission to the placenta and widespread infection throughout the decidua, basal zone, and labyrinth zone. Some pups from infected dams appeared normal while others had gross signs of teratogenicity including death. Histopathological lesions were detected in placenta from pups regardless of teratogenicity, while teratogenic pups had widespread hemorrhage throughout multiple placenta layers. Teratogenic events were associated with significant increases in placental pro-inflammatory cytokines, type I interferons, and chemokines. RVFV displays a high degree of tropism for all placental tissue layers and the degree of hemorrhage and inflammatory mediator production is highest in placenta from pups with adverse outcomes. Given the potential for RVFV to emerge in new locations and the recent evidence of emerging viruses, like Zika and SARS-CoV-2, to undergo vertical transmission, this study provides essential understanding regarding the mechanisms by which RVFV crosses the placenta barrier. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Labyrinth ENVELOPE(160.833,160.833,-77.550,-77.550) PLOS Neglected Tropical Diseases 16 10 e0010898 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Cynthia M McMillen Devin A Boyles Stefan G Kostadinov Ryan M Hoehl Madeline M Schwarz Joseph R Albe Matthew J Demers Amy L Hartman Congenital Rift Valley fever in Sprague Dawley rats is associated with diffuse infection and pathology of the placenta. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Rift Valley fever (RVF) is a disease of animals and humans associated with abortions in ruminants and late-gestation miscarriages in women. Here, we use a rat model of congenital RVF to identify tropisms, pathologies, and immune responses in the placenta during vertical transmission. Infection of late-gestation pregnant rats resulted in vertical transmission to the placenta and widespread infection throughout the decidua, basal zone, and labyrinth zone. Some pups from infected dams appeared normal while others had gross signs of teratogenicity including death. Histopathological lesions were detected in placenta from pups regardless of teratogenicity, while teratogenic pups had widespread hemorrhage throughout multiple placenta layers. Teratogenic events were associated with significant increases in placental pro-inflammatory cytokines, type I interferons, and chemokines. RVFV displays a high degree of tropism for all placental tissue layers and the degree of hemorrhage and inflammatory mediator production is highest in placenta from pups with adverse outcomes. Given the potential for RVFV to emerge in new locations and the recent evidence of emerging viruses, like Zika and SARS-CoV-2, to undergo vertical transmission, this study provides essential understanding regarding the mechanisms by which RVFV crosses the placenta barrier. |
format |
Article in Journal/Newspaper |
author |
Cynthia M McMillen Devin A Boyles Stefan G Kostadinov Ryan M Hoehl Madeline M Schwarz Joseph R Albe Matthew J Demers Amy L Hartman |
author_facet |
Cynthia M McMillen Devin A Boyles Stefan G Kostadinov Ryan M Hoehl Madeline M Schwarz Joseph R Albe Matthew J Demers Amy L Hartman |
author_sort |
Cynthia M McMillen |
title |
Congenital Rift Valley fever in Sprague Dawley rats is associated with diffuse infection and pathology of the placenta. |
title_short |
Congenital Rift Valley fever in Sprague Dawley rats is associated with diffuse infection and pathology of the placenta. |
title_full |
Congenital Rift Valley fever in Sprague Dawley rats is associated with diffuse infection and pathology of the placenta. |
title_fullStr |
Congenital Rift Valley fever in Sprague Dawley rats is associated with diffuse infection and pathology of the placenta. |
title_full_unstemmed |
Congenital Rift Valley fever in Sprague Dawley rats is associated with diffuse infection and pathology of the placenta. |
title_sort |
congenital rift valley fever in sprague dawley rats is associated with diffuse infection and pathology of the placenta. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010898 https://doaj.org/article/252dffdec9d24454814de48ee8408d52 |
long_lat |
ENVELOPE(160.833,160.833,-77.550,-77.550) |
geographic |
Arctic Labyrinth |
geographic_facet |
Arctic Labyrinth |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 10, p e0010898 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010898 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010898 https://doaj.org/article/252dffdec9d24454814de48ee8408d52 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010898 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
16 |
container_issue |
10 |
container_start_page |
e0010898 |
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1771543487362105344 |