Pre- and post-bronchodilator airway obstruction are associated with similar clinical characteristics but different prognosis – report from a population-based study
Sami Sawalha,1 Linnea Hedman,2 Eva Rönmark,2 Bo Lundbäck,3 Anne Lindberg1 1Department of Public Health and Clinical Medicine, Division of Medicine, 2Department of Public Health and Clinical Medicine, The OLIN Unit, Division of Occupational and Environmental Medicine, Umeå University, Umeå, 3Krefting...
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ftdoajarticles:oai:doaj.org/article:251a488b7377498fbce18e781b006414 2023-05-15T18:13:31+02:00 Pre- and post-bronchodilator airway obstruction are associated with similar clinical characteristics but different prognosis – report from a population-based study Sawalha S Hedman L Rönmark E Lundbäck B Lindberg A 2017-04-01T00:00:00Z https://doaj.org/article/251a488b7377498fbce18e781b006414 EN eng Dove Medical Press https://www.dovepress.com/pre--and-post-bronchodilator-airway-obstruction-are-associated-with-s-peer-reviewed-article-COPD https://doaj.org/toc/1178-2005 1178-2005 https://doaj.org/article/251a488b7377498fbce18e781b006414 International Journal of COPD, Vol Volume 12, Pp 1269-1277 (2017) epidemiology spirometry chronic airflow obstructions mortality Diseases of the respiratory system RC705-779 article 2017 ftdoajarticles 2022-12-31T07:11:50Z Sami Sawalha,1 Linnea Hedman,2 Eva Rönmark,2 Bo Lundbäck,3 Anne Lindberg1 1Department of Public Health and Clinical Medicine, Division of Medicine, 2Department of Public Health and Clinical Medicine, The OLIN Unit, Division of Occupational and Environmental Medicine, Umeå University, Umeå, 3Krefting Research Center, Institution of Medicine, University of Gothenburg, Gothenburg, Sweden Introduction: According to guidelines, the diagnosis of COPD should be confirmed by post-bronchodilator (post-BD) airway obstruction on spirometry; however, in clinical practice, this is not always performed. The aim of this population-based study was to compare clinical characteristics and prognosis, assessed as mortality, between subjects with airway obstruction divided into pre- but not post-BD obstruction, post-BD airway obstruction (COPD), and subjects without airway obstruction.Materials and methods: In 2002–2004, four adult population-based cohorts were reexamined with spirometry and structured interview. Subjects with airway obstruction, with a ratio of forced expiratory volume in 1 s to (forced) vital capacity <0.70 (n=993), were identified together with sex- and age-matched referents (n=993). These subjects were further divided into subjects with pre- but not post-BD airway obstruction (pre- not post-BD obstruction) and subjects with post-BD airway obstruction (COPD). Mortality data were collected until December 31, 2014.Results: Out of 993 subjects with airway obstruction, 736 (74%) had COPD and 257 (26%) pre- not post-BD obstruction. Any respiratory symptoms, allergic rhinitis, asthma, exacerbations, and comorbidities were equally common among subjects with COPD and pre- not post-BD obstruction, but less common among nonobstructive subjects. Mortality was highest among subjects with COPD and higher in men than in women. In both sexes, COPD, but not pre- not post-BD obstruction, was associated with an increased risk for death compared to those without airway obstruction. When COPD was divided into Global Initiative ... Article in Journal/Newspaper sami Directory of Open Access Journals: DOAJ Articles |
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Directory of Open Access Journals: DOAJ Articles |
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epidemiology spirometry chronic airflow obstructions mortality Diseases of the respiratory system RC705-779 |
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epidemiology spirometry chronic airflow obstructions mortality Diseases of the respiratory system RC705-779 Sawalha S Hedman L Rönmark E Lundbäck B Lindberg A Pre- and post-bronchodilator airway obstruction are associated with similar clinical characteristics but different prognosis – report from a population-based study |
topic_facet |
epidemiology spirometry chronic airflow obstructions mortality Diseases of the respiratory system RC705-779 |
description |
Sami Sawalha,1 Linnea Hedman,2 Eva Rönmark,2 Bo Lundbäck,3 Anne Lindberg1 1Department of Public Health and Clinical Medicine, Division of Medicine, 2Department of Public Health and Clinical Medicine, The OLIN Unit, Division of Occupational and Environmental Medicine, Umeå University, Umeå, 3Krefting Research Center, Institution of Medicine, University of Gothenburg, Gothenburg, Sweden Introduction: According to guidelines, the diagnosis of COPD should be confirmed by post-bronchodilator (post-BD) airway obstruction on spirometry; however, in clinical practice, this is not always performed. The aim of this population-based study was to compare clinical characteristics and prognosis, assessed as mortality, between subjects with airway obstruction divided into pre- but not post-BD obstruction, post-BD airway obstruction (COPD), and subjects without airway obstruction.Materials and methods: In 2002–2004, four adult population-based cohorts were reexamined with spirometry and structured interview. Subjects with airway obstruction, with a ratio of forced expiratory volume in 1 s to (forced) vital capacity <0.70 (n=993), were identified together with sex- and age-matched referents (n=993). These subjects were further divided into subjects with pre- but not post-BD airway obstruction (pre- not post-BD obstruction) and subjects with post-BD airway obstruction (COPD). Mortality data were collected until December 31, 2014.Results: Out of 993 subjects with airway obstruction, 736 (74%) had COPD and 257 (26%) pre- not post-BD obstruction. Any respiratory symptoms, allergic rhinitis, asthma, exacerbations, and comorbidities were equally common among subjects with COPD and pre- not post-BD obstruction, but less common among nonobstructive subjects. Mortality was highest among subjects with COPD and higher in men than in women. In both sexes, COPD, but not pre- not post-BD obstruction, was associated with an increased risk for death compared to those without airway obstruction. When COPD was divided into Global Initiative ... |
format |
Article in Journal/Newspaper |
author |
Sawalha S Hedman L Rönmark E Lundbäck B Lindberg A |
author_facet |
Sawalha S Hedman L Rönmark E Lundbäck B Lindberg A |
author_sort |
Sawalha S |
title |
Pre- and post-bronchodilator airway obstruction are associated with similar clinical characteristics but different prognosis – report from a population-based study |
title_short |
Pre- and post-bronchodilator airway obstruction are associated with similar clinical characteristics but different prognosis – report from a population-based study |
title_full |
Pre- and post-bronchodilator airway obstruction are associated with similar clinical characteristics but different prognosis – report from a population-based study |
title_fullStr |
Pre- and post-bronchodilator airway obstruction are associated with similar clinical characteristics but different prognosis – report from a population-based study |
title_full_unstemmed |
Pre- and post-bronchodilator airway obstruction are associated with similar clinical characteristics but different prognosis – report from a population-based study |
title_sort |
pre- and post-bronchodilator airway obstruction are associated with similar clinical characteristics but different prognosis – report from a population-based study |
publisher |
Dove Medical Press |
publishDate |
2017 |
url |
https://doaj.org/article/251a488b7377498fbce18e781b006414 |
genre |
sami |
genre_facet |
sami |
op_source |
International Journal of COPD, Vol Volume 12, Pp 1269-1277 (2017) |
op_relation |
https://www.dovepress.com/pre--and-post-bronchodilator-airway-obstruction-are-associated-with-s-peer-reviewed-article-COPD https://doaj.org/toc/1178-2005 1178-2005 https://doaj.org/article/251a488b7377498fbce18e781b006414 |
_version_ |
1766186080939278336 |