Unsuspected Dengue as a Cause of Acute Febrile Illness in Children and Adults in Western Nicaragua.
BACKGROUND:Dengue is an emerging infectious disease of global significance. Suspected dengue, especially in children in Nicaragua's heavily-urbanized capital of Managua, has been well documented, but unsuspected dengue among children and adults with undifferentitated fever has not. METHODOLOGY/...
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ftdoajarticles:oai:doaj.org/article:24d078776d2f45da9f5d5ff4369bd395 2023-05-15T15:09:18+02:00 Unsuspected Dengue as a Cause of Acute Febrile Illness in Children and Adults in Western Nicaragua. Megan E Reller Aravinda M de Silva Jeremy J Miles Ramesh S Jadi Anne Broadwater Katie Walker Christopher Woods Orlando Mayorga Armando Matute 2016-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005026 https://doaj.org/article/24d078776d2f45da9f5d5ff4369bd395 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5085067?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005026 https://doaj.org/article/24d078776d2f45da9f5d5ff4369bd395 PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005026 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005026 2022-12-31T01:02:22Z BACKGROUND:Dengue is an emerging infectious disease of global significance. Suspected dengue, especially in children in Nicaragua's heavily-urbanized capital of Managua, has been well documented, but unsuspected dengue among children and adults with undifferentitated fever has not. METHODOLOGY/PRINCIPAL FINDINGS:To prospectively study dengue in semi-urban and rural western Nicaragua, we obtained epidemiologic and clinical data as well as acute and convalescent sera (2 to 4 weeks after onset of illness) from a convenience sample (enrollment Monday to Saturday daytime to early evening) of consecutively enrolled patients (n = 740) aged ≥ 1 years presenting with acute febrile illness. We tested paired sera for dengue IgG and IgM and serotyped dengue virus using reverse transcriptase-PCR. Among 740 febrile patients enrolled, 90% had paired sera. We found 470 (63.5%) were seropositive for dengue at enrollment. The dengue seroprevalance increased with age and reached >90% in people over the age of 20 years. We identified acute dengue (serotypes 1 and 2) in 38 (5.1%) patients. Only 8.1% (3/37) of confirmed cases were suspected clinically. CONCLUSIONS/SIGNIFICANCE:Dengue is an important and largely unrecognized cause of fever in rural western Nicaragua. Since Zika virus is transmitted by the same vector and has been associated with severe congenital infections, the population we studied is at particular risk for being devastated by the Zika epidemic that has now reached Central America. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 10 e0005026 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Megan E Reller Aravinda M de Silva Jeremy J Miles Ramesh S Jadi Anne Broadwater Katie Walker Christopher Woods Orlando Mayorga Armando Matute Unsuspected Dengue as a Cause of Acute Febrile Illness in Children and Adults in Western Nicaragua. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Dengue is an emerging infectious disease of global significance. Suspected dengue, especially in children in Nicaragua's heavily-urbanized capital of Managua, has been well documented, but unsuspected dengue among children and adults with undifferentitated fever has not. METHODOLOGY/PRINCIPAL FINDINGS:To prospectively study dengue in semi-urban and rural western Nicaragua, we obtained epidemiologic and clinical data as well as acute and convalescent sera (2 to 4 weeks after onset of illness) from a convenience sample (enrollment Monday to Saturday daytime to early evening) of consecutively enrolled patients (n = 740) aged ≥ 1 years presenting with acute febrile illness. We tested paired sera for dengue IgG and IgM and serotyped dengue virus using reverse transcriptase-PCR. Among 740 febrile patients enrolled, 90% had paired sera. We found 470 (63.5%) were seropositive for dengue at enrollment. The dengue seroprevalance increased with age and reached >90% in people over the age of 20 years. We identified acute dengue (serotypes 1 and 2) in 38 (5.1%) patients. Only 8.1% (3/37) of confirmed cases were suspected clinically. CONCLUSIONS/SIGNIFICANCE:Dengue is an important and largely unrecognized cause of fever in rural western Nicaragua. Since Zika virus is transmitted by the same vector and has been associated with severe congenital infections, the population we studied is at particular risk for being devastated by the Zika epidemic that has now reached Central America. |
format |
Article in Journal/Newspaper |
author |
Megan E Reller Aravinda M de Silva Jeremy J Miles Ramesh S Jadi Anne Broadwater Katie Walker Christopher Woods Orlando Mayorga Armando Matute |
author_facet |
Megan E Reller Aravinda M de Silva Jeremy J Miles Ramesh S Jadi Anne Broadwater Katie Walker Christopher Woods Orlando Mayorga Armando Matute |
author_sort |
Megan E Reller |
title |
Unsuspected Dengue as a Cause of Acute Febrile Illness in Children and Adults in Western Nicaragua. |
title_short |
Unsuspected Dengue as a Cause of Acute Febrile Illness in Children and Adults in Western Nicaragua. |
title_full |
Unsuspected Dengue as a Cause of Acute Febrile Illness in Children and Adults in Western Nicaragua. |
title_fullStr |
Unsuspected Dengue as a Cause of Acute Febrile Illness in Children and Adults in Western Nicaragua. |
title_full_unstemmed |
Unsuspected Dengue as a Cause of Acute Febrile Illness in Children and Adults in Western Nicaragua. |
title_sort |
unsuspected dengue as a cause of acute febrile illness in children and adults in western nicaragua. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0005026 https://doaj.org/article/24d078776d2f45da9f5d5ff4369bd395 |
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Arctic |
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Arctic |
genre |
Arctic |
genre_facet |
Arctic |
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PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005026 (2016) |
op_relation |
http://europepmc.org/articles/PMC5085067?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005026 https://doaj.org/article/24d078776d2f45da9f5d5ff4369bd395 |
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https://doi.org/10.1371/journal.pntd.0005026 |
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PLOS Neglected Tropical Diseases |
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e0005026 |
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