Genetic characterization of Venezuelan equine encephalitis virus from Bolivia, Ecuador and Peru: identification of a new subtype ID lineage.
Venezuelan equine encephalitis virus (VEEV) has been responsible for hundreds of thousands of human and equine cases of severe disease in the Americas. A passive surveillance study was conducted in Peru, Bolivia and Ecuador to determine the arboviral etiology of febrile illness. Patients with suspec...
Published in: | PLoS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0000514 https://doaj.org/article/24bc19211c4240d287c94d8d9c2630a2 |
id |
ftdoajarticles:oai:doaj.org/article:24bc19211c4240d287c94d8d9c2630a2 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:24bc19211c4240d287c94d8d9c2630a2 2023-05-15T15:11:47+02:00 Genetic characterization of Venezuelan equine encephalitis virus from Bolivia, Ecuador and Peru: identification of a new subtype ID lineage. Patricia V Aguilar A Paige Adams Victor Suárez Luis Beingolea Jorge Vargas Stephen Manock Juan Freire Willan R Espinoza Vidal Felices Ana Diaz Xiaodong Liang Yelin Roca Scott C Weaver Tadeusz J Kochel 2009-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000514 https://doaj.org/article/24bc19211c4240d287c94d8d9c2630a2 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2734058?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000514 https://doaj.org/article/24bc19211c4240d287c94d8d9c2630a2 PLoS Neglected Tropical Diseases, Vol 3, Iss 9, p e514 (2009) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2009 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000514 2022-12-31T09:50:09Z Venezuelan equine encephalitis virus (VEEV) has been responsible for hundreds of thousands of human and equine cases of severe disease in the Americas. A passive surveillance study was conducted in Peru, Bolivia and Ecuador to determine the arboviral etiology of febrile illness. Patients with suspected viral-associated, acute, undifferentiated febrile illness of <7 days duration were enrolled in the study and blood samples were obtained from each patient and assayed by virus isolation. Demographic and clinical information from each patient was also obtained at the time of voluntary enrollment. In 2005-2007, cases of Venezuelan equine encephalitis (VEE) were diagnosed for the first time in residents of Bolivia; the patients did not report traveling, suggesting endemic circulation of VEEV in Bolivia. In 2001 and 2003, VEE cases were also identified in Ecuador. Since 1993, VEEV has been continuously isolated from patients in Loreto, Peru, and more recently (2005), in Madre de Dios, Peru. We performed phylogenetic analyses with VEEV from Bolivia, Ecuador and Peru and compared their relationships to strains from other parts of South America. We found that VEEV subtype ID Panama/Peru genotype is the predominant one circulating in Peru. We also demonstrated that VEEV subtype ID strains circulating in Ecuador belong to the Colombia/Venezuela genotype and VEEV from Madre de Dios, Peru and Cochabamba, Bolivia belong to a new ID genotype. In summary, we identified a new major lineage of enzootic VEEV subtype ID, information that could aid in the understanding of the emergence and evolution of VEEV in South America. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 3 9 e514 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Patricia V Aguilar A Paige Adams Victor Suárez Luis Beingolea Jorge Vargas Stephen Manock Juan Freire Willan R Espinoza Vidal Felices Ana Diaz Xiaodong Liang Yelin Roca Scott C Weaver Tadeusz J Kochel Genetic characterization of Venezuelan equine encephalitis virus from Bolivia, Ecuador and Peru: identification of a new subtype ID lineage. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Venezuelan equine encephalitis virus (VEEV) has been responsible for hundreds of thousands of human and equine cases of severe disease in the Americas. A passive surveillance study was conducted in Peru, Bolivia and Ecuador to determine the arboviral etiology of febrile illness. Patients with suspected viral-associated, acute, undifferentiated febrile illness of <7 days duration were enrolled in the study and blood samples were obtained from each patient and assayed by virus isolation. Demographic and clinical information from each patient was also obtained at the time of voluntary enrollment. In 2005-2007, cases of Venezuelan equine encephalitis (VEE) were diagnosed for the first time in residents of Bolivia; the patients did not report traveling, suggesting endemic circulation of VEEV in Bolivia. In 2001 and 2003, VEE cases were also identified in Ecuador. Since 1993, VEEV has been continuously isolated from patients in Loreto, Peru, and more recently (2005), in Madre de Dios, Peru. We performed phylogenetic analyses with VEEV from Bolivia, Ecuador and Peru and compared their relationships to strains from other parts of South America. We found that VEEV subtype ID Panama/Peru genotype is the predominant one circulating in Peru. We also demonstrated that VEEV subtype ID strains circulating in Ecuador belong to the Colombia/Venezuela genotype and VEEV from Madre de Dios, Peru and Cochabamba, Bolivia belong to a new ID genotype. In summary, we identified a new major lineage of enzootic VEEV subtype ID, information that could aid in the understanding of the emergence and evolution of VEEV in South America. |
format |
Article in Journal/Newspaper |
author |
Patricia V Aguilar A Paige Adams Victor Suárez Luis Beingolea Jorge Vargas Stephen Manock Juan Freire Willan R Espinoza Vidal Felices Ana Diaz Xiaodong Liang Yelin Roca Scott C Weaver Tadeusz J Kochel |
author_facet |
Patricia V Aguilar A Paige Adams Victor Suárez Luis Beingolea Jorge Vargas Stephen Manock Juan Freire Willan R Espinoza Vidal Felices Ana Diaz Xiaodong Liang Yelin Roca Scott C Weaver Tadeusz J Kochel |
author_sort |
Patricia V Aguilar |
title |
Genetic characterization of Venezuelan equine encephalitis virus from Bolivia, Ecuador and Peru: identification of a new subtype ID lineage. |
title_short |
Genetic characterization of Venezuelan equine encephalitis virus from Bolivia, Ecuador and Peru: identification of a new subtype ID lineage. |
title_full |
Genetic characterization of Venezuelan equine encephalitis virus from Bolivia, Ecuador and Peru: identification of a new subtype ID lineage. |
title_fullStr |
Genetic characterization of Venezuelan equine encephalitis virus from Bolivia, Ecuador and Peru: identification of a new subtype ID lineage. |
title_full_unstemmed |
Genetic characterization of Venezuelan equine encephalitis virus from Bolivia, Ecuador and Peru: identification of a new subtype ID lineage. |
title_sort |
genetic characterization of venezuelan equine encephalitis virus from bolivia, ecuador and peru: identification of a new subtype id lineage. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2009 |
url |
https://doi.org/10.1371/journal.pntd.0000514 https://doaj.org/article/24bc19211c4240d287c94d8d9c2630a2 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 3, Iss 9, p e514 (2009) |
op_relation |
http://europepmc.org/articles/PMC2734058?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000514 https://doaj.org/article/24bc19211c4240d287c94d8d9c2630a2 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000514 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
3 |
container_issue |
9 |
container_start_page |
e514 |
_version_ |
1766342576662642688 |