Appropriate antivenom doses for six types of envenomations caused by snakes in taiwan
Six of the 15 species of venomous snakes found in Taiwan are responsible for most of the clinically significant envenomations in the country. These species are: Trimeresurus mucrosquamatus, Trimeresurus stejnegeri, Naja atra, Bungarus multicinctus, Deinagkistrodon acutus and Daboia russelii siamensi...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:2482a3e5bb9846e8a8593daf7bbed83d 2023-05-15T15:10:08+02:00 Appropriate antivenom doses for six types of envenomations caused by snakes in taiwan C Chieh-Fan L Tzeng-Jih H Wen-Chi Y Hua-Wei 2009-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992009000300009 https://doaj.org/article/2482a3e5bb9846e8a8593daf7bbed83d EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000300009 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992009000300009 1678-9199 https://doaj.org/article/2482a3e5bb9846e8a8593daf7bbed83d Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 15, Iss 3, Pp 479-490 (2009) antivenom venomous snakes snake envenomation neurotoxic venom hemorrhagic venom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2009 ftdoajarticles https://doi.org/10.1590/S1678-91992009000300009 2022-12-31T04:15:52Z Six of the 15 species of venomous snakes found in Taiwan are responsible for most of the clinically significant envenomations in the country. These species are: Trimeresurus mucrosquamatus, Trimeresurus stejnegeri, Naja atra, Bungarus multicinctus, Deinagkistrodon acutus and Daboia russelii siamensis, which together can be subdivided into three groups based on their venom effects. Primary treatment consists of rapid administration of appropriate antivenoms. The present study aimed to identify a proper dose of antivenom for each snake group as well as to describe hemorrhagic, neurotoxic, and mixed effects of their venoms. A retrospective chart review identified 72 snakebite cases referred to an emergency department. Data on epidemiology, examination findings, snake identification, treatment, antivenom dose and complications were collected. After excluding 14 patients, data from 58 victims were analyzed. Most studied cases were male (86%). Significantly higher doses of antivenom were administered against neurotoxic envenomations (mean dose: three vials) compared with the other two (p < 0.05). Moreover, patients affected by neurotoxic bites were more likely to develop blurred vision and other complications (p < 0.05). Multivariate logistic regression analysis indicated that neurotoxic envenomation was a risk factor for complications (OR: 8.84, 95% CI: 1.06-73.73). Neurotoxic envenomations and complication occurrence were positively correlated with antivenom dosage. In conclusion, patients affected by neurotoxic envenomations received higher doses of antivenom than others whereas incidence of complications was associated with higher antivenom doses. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 15 3 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
antivenom venomous snakes snake envenomation neurotoxic venom hemorrhagic venom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
antivenom venomous snakes snake envenomation neurotoxic venom hemorrhagic venom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 C Chieh-Fan L Tzeng-Jih H Wen-Chi Y Hua-Wei Appropriate antivenom doses for six types of envenomations caused by snakes in taiwan |
topic_facet |
antivenom venomous snakes snake envenomation neurotoxic venom hemorrhagic venom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Six of the 15 species of venomous snakes found in Taiwan are responsible for most of the clinically significant envenomations in the country. These species are: Trimeresurus mucrosquamatus, Trimeresurus stejnegeri, Naja atra, Bungarus multicinctus, Deinagkistrodon acutus and Daboia russelii siamensis, which together can be subdivided into three groups based on their venom effects. Primary treatment consists of rapid administration of appropriate antivenoms. The present study aimed to identify a proper dose of antivenom for each snake group as well as to describe hemorrhagic, neurotoxic, and mixed effects of their venoms. A retrospective chart review identified 72 snakebite cases referred to an emergency department. Data on epidemiology, examination findings, snake identification, treatment, antivenom dose and complications were collected. After excluding 14 patients, data from 58 victims were analyzed. Most studied cases were male (86%). Significantly higher doses of antivenom were administered against neurotoxic envenomations (mean dose: three vials) compared with the other two (p < 0.05). Moreover, patients affected by neurotoxic bites were more likely to develop blurred vision and other complications (p < 0.05). Multivariate logistic regression analysis indicated that neurotoxic envenomation was a risk factor for complications (OR: 8.84, 95% CI: 1.06-73.73). Neurotoxic envenomations and complication occurrence were positively correlated with antivenom dosage. In conclusion, patients affected by neurotoxic envenomations received higher doses of antivenom than others whereas incidence of complications was associated with higher antivenom doses. |
format |
Article in Journal/Newspaper |
author |
C Chieh-Fan L Tzeng-Jih H Wen-Chi Y Hua-Wei |
author_facet |
C Chieh-Fan L Tzeng-Jih H Wen-Chi Y Hua-Wei |
author_sort |
C Chieh-Fan |
title |
Appropriate antivenom doses for six types of envenomations caused by snakes in taiwan |
title_short |
Appropriate antivenom doses for six types of envenomations caused by snakes in taiwan |
title_full |
Appropriate antivenom doses for six types of envenomations caused by snakes in taiwan |
title_fullStr |
Appropriate antivenom doses for six types of envenomations caused by snakes in taiwan |
title_full_unstemmed |
Appropriate antivenom doses for six types of envenomations caused by snakes in taiwan |
title_sort |
appropriate antivenom doses for six types of envenomations caused by snakes in taiwan |
publisher |
SciELO |
publishDate |
2009 |
url |
https://doi.org/10.1590/S1678-91992009000300009 https://doaj.org/article/2482a3e5bb9846e8a8593daf7bbed83d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 15, Iss 3, Pp 479-490 (2009) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000300009 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992009000300009 1678-9199 https://doaj.org/article/2482a3e5bb9846e8a8593daf7bbed83d |
op_doi |
https://doi.org/10.1590/S1678-91992009000300009 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
15 |
container_issue |
3 |
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1766341180135571456 |