Molecular evidence of mother-to-child transmission of HTLV-IIc in the Kararao Village (Kayapo) in the Amazon Region of Brazil
Blood samples from native Indians in the Kararao village (Kayapo), were analysed using serological and molecular methods to characterize infection and analyse transmission of HTLV-II. Specific reactivity was observed in 3/26 individuals, of which two samples were from a mother and child. RFLP analys...
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Sociedade Brasileira de Medicina Tropical (SBMT)
2001
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ftdoajarticles:oai:doaj.org/article:247a8814410f461f9861362b34bc4448 2023-05-15T15:07:34+02:00 Molecular evidence of mother-to-child transmission of HTLV-IIc in the Kararao Village (Kayapo) in the Amazon Region of Brazil Ishak Ricardo Vallinoto Antonio Carlos R. Azevedo Vânia Nakauth Lewis Martha Hall William W. Ishak Marluísa O. Guimarães 2001-01-01T00:00:00Z https://doaj.org/article/247a8814410f461f9861362b34bc4448 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822001000600004 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/247a8814410f461f9861362b34bc4448 Revista da Sociedade Brasileira de Medicina Tropical, Vol 34, Iss 6, Pp 519-525 (2001) HTLV-II Molecular epidemiology Vertical transmission Amerindian populations Arctic medicine. Tropical medicine RC955-962 article 2001 ftdoajarticles 2022-12-30T21:38:31Z Blood samples from native Indians in the Kararao village (Kayapo), were analysed using serological and molecular methods to characterize infection and analyse transmission of HTLV-II. Specific reactivity was observed in 3/26 individuals, of which two samples were from a mother and child. RFLP analysis of the pX and env regions confirmed HTLV-II infection. Nucleotide sequence of the 5' LTR segment and phylogenetic analysis showed a high similarity (98%) between the three samples and prototype HTLV-IIa (Mot), and confirmed the occurrence of the HTLV-IIc subtype. There was a high genetic similarity (99.9%) between the mother and child samples and the only difference was a deletion of two nucleotides (TC) in the mother sequence. Previous epidemiological studies among native Indians from Brazil have provided evidence of intrafamilial and vertical transmission of HTLV-IIc. The present study now provides molecular evidence of mother-to-child transmission of HTLV-IIc, a mechanism that is in large part responsible for the endemicity of HTLV in these relatively closed populations. Although the actual route of transmission is unknown, breast feeding would appear to be most likely. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
HTLV-II Molecular epidemiology Vertical transmission Amerindian populations Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
HTLV-II Molecular epidemiology Vertical transmission Amerindian populations Arctic medicine. Tropical medicine RC955-962 Ishak Ricardo Vallinoto Antonio Carlos R. Azevedo Vânia Nakauth Lewis Martha Hall William W. Ishak Marluísa O. Guimarães Molecular evidence of mother-to-child transmission of HTLV-IIc in the Kararao Village (Kayapo) in the Amazon Region of Brazil |
topic_facet |
HTLV-II Molecular epidemiology Vertical transmission Amerindian populations Arctic medicine. Tropical medicine RC955-962 |
description |
Blood samples from native Indians in the Kararao village (Kayapo), were analysed using serological and molecular methods to characterize infection and analyse transmission of HTLV-II. Specific reactivity was observed in 3/26 individuals, of which two samples were from a mother and child. RFLP analysis of the pX and env regions confirmed HTLV-II infection. Nucleotide sequence of the 5' LTR segment and phylogenetic analysis showed a high similarity (98%) between the three samples and prototype HTLV-IIa (Mot), and confirmed the occurrence of the HTLV-IIc subtype. There was a high genetic similarity (99.9%) between the mother and child samples and the only difference was a deletion of two nucleotides (TC) in the mother sequence. Previous epidemiological studies among native Indians from Brazil have provided evidence of intrafamilial and vertical transmission of HTLV-IIc. The present study now provides molecular evidence of mother-to-child transmission of HTLV-IIc, a mechanism that is in large part responsible for the endemicity of HTLV in these relatively closed populations. Although the actual route of transmission is unknown, breast feeding would appear to be most likely. |
format |
Article in Journal/Newspaper |
author |
Ishak Ricardo Vallinoto Antonio Carlos R. Azevedo Vânia Nakauth Lewis Martha Hall William W. Ishak Marluísa O. Guimarães |
author_facet |
Ishak Ricardo Vallinoto Antonio Carlos R. Azevedo Vânia Nakauth Lewis Martha Hall William W. Ishak Marluísa O. Guimarães |
author_sort |
Ishak Ricardo |
title |
Molecular evidence of mother-to-child transmission of HTLV-IIc in the Kararao Village (Kayapo) in the Amazon Region of Brazil |
title_short |
Molecular evidence of mother-to-child transmission of HTLV-IIc in the Kararao Village (Kayapo) in the Amazon Region of Brazil |
title_full |
Molecular evidence of mother-to-child transmission of HTLV-IIc in the Kararao Village (Kayapo) in the Amazon Region of Brazil |
title_fullStr |
Molecular evidence of mother-to-child transmission of HTLV-IIc in the Kararao Village (Kayapo) in the Amazon Region of Brazil |
title_full_unstemmed |
Molecular evidence of mother-to-child transmission of HTLV-IIc in the Kararao Village (Kayapo) in the Amazon Region of Brazil |
title_sort |
molecular evidence of mother-to-child transmission of htlv-iic in the kararao village (kayapo) in the amazon region of brazil |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2001 |
url |
https://doaj.org/article/247a8814410f461f9861362b34bc4448 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 34, Iss 6, Pp 519-525 (2001) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822001000600004 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/247a8814410f461f9861362b34bc4448 |
_version_ |
1766339044839522304 |