Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner.
Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis and is caused by several species of Leishmania parasite. Clinical presentation of CL varies from a self-healing infection to a chronic form of the disease determined by the virulence of infecting Leishmania species and host immune...
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ftdoajarticles:oai:doaj.org/article:24384e00ef204afaae191ff676d7f220 2023-05-15T15:08:51+02:00 Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner. Md Abu Musa Risa Nakamura Asma Hena Sanjay Varikuti Hira L Nakhasi Yasuyuki Goto Abhay R Satoskar Shinjiro Hamano 2019-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007865 https://doaj.org/article/24384e00ef204afaae191ff676d7f220 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007865 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007865 https://doaj.org/article/24384e00ef204afaae191ff676d7f220 PLoS Neglected Tropical Diseases, Vol 13, Iss 11, p e0007865 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007865 2022-12-31T07:16:57Z Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis and is caused by several species of Leishmania parasite. Clinical presentation of CL varies from a self-healing infection to a chronic form of the disease determined by the virulence of infecting Leishmania species and host immune responses to the parasite. Mouse models of CL show contradictory roles of lymphocytes in pathogenesis, while acquired immune responses are responsible for host protection from diseases. To reconcile the inconclusive roles of acquired immune responses in pathogenesis, we infected mice from various genetic backgrounds with two pathogenic strains of Leishmania major, Friedlin or 5ASKH, and assessed the outcome of the infections. Our findings showed that the genetic backgrounds of L. major determine the impact of lymphocytes for pathogenesis. In the absence of lymphocytes, L. major Friedlin induced the lowest inflammatory reaction and pathology at the site of infection, while 5ASKH infection induced a strong inflammatory reaction and severe pathology. Lymphocytes ameliorated 5ASKH mediated pathology, while it exacerbated pathology during Friedlin infection. Excess inflammatory reactions, like the recruitment of macrophages, neutrophils, eosinophils and production of pro-inflammatory cytokines, together with uncontrolled parasite growth in the absence of lymphocytes during 5ASKH infection may induce severe pathology development. Taken together our study provides insight into the impact of differences in the genetic background of Leishmania on CL pathogenesis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 11 e0007865 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Md Abu Musa Risa Nakamura Asma Hena Sanjay Varikuti Hira L Nakhasi Yasuyuki Goto Abhay R Satoskar Shinjiro Hamano Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis and is caused by several species of Leishmania parasite. Clinical presentation of CL varies from a self-healing infection to a chronic form of the disease determined by the virulence of infecting Leishmania species and host immune responses to the parasite. Mouse models of CL show contradictory roles of lymphocytes in pathogenesis, while acquired immune responses are responsible for host protection from diseases. To reconcile the inconclusive roles of acquired immune responses in pathogenesis, we infected mice from various genetic backgrounds with two pathogenic strains of Leishmania major, Friedlin or 5ASKH, and assessed the outcome of the infections. Our findings showed that the genetic backgrounds of L. major determine the impact of lymphocytes for pathogenesis. In the absence of lymphocytes, L. major Friedlin induced the lowest inflammatory reaction and pathology at the site of infection, while 5ASKH infection induced a strong inflammatory reaction and severe pathology. Lymphocytes ameliorated 5ASKH mediated pathology, while it exacerbated pathology during Friedlin infection. Excess inflammatory reactions, like the recruitment of macrophages, neutrophils, eosinophils and production of pro-inflammatory cytokines, together with uncontrolled parasite growth in the absence of lymphocytes during 5ASKH infection may induce severe pathology development. Taken together our study provides insight into the impact of differences in the genetic background of Leishmania on CL pathogenesis. |
format |
Article in Journal/Newspaper |
author |
Md Abu Musa Risa Nakamura Asma Hena Sanjay Varikuti Hira L Nakhasi Yasuyuki Goto Abhay R Satoskar Shinjiro Hamano |
author_facet |
Md Abu Musa Risa Nakamura Asma Hena Sanjay Varikuti Hira L Nakhasi Yasuyuki Goto Abhay R Satoskar Shinjiro Hamano |
author_sort |
Md Abu Musa |
title |
Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner. |
title_short |
Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner. |
title_full |
Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner. |
title_fullStr |
Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner. |
title_full_unstemmed |
Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner. |
title_sort |
lymphocytes influence leishmania major pathogenesis in a strain-dependent manner. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007865 https://doaj.org/article/24384e00ef204afaae191ff676d7f220 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 11, p e0007865 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007865 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007865 https://doaj.org/article/24384e00ef204afaae191ff676d7f220 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007865 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
11 |
container_start_page |
e0007865 |
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1766340125716905984 |