Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: an additional mechanism for the hypolipidemic effects of berberine
Objective: To evaluate the effects of berberine (BBR) on the liver phosphatidate phosphohydrolase (PAP) and plasma lipids in rats fed on high lipogenic and normal diet. Methods: Forty rats were randomly divided into 5 groups. Group I (control) received standard diet. Group II received standard diet...
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Wolters Kluwer Medknow Publications
2014
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Online Access: | https://doi.org/10.12980/APJTB.4.2014C474 https://doaj.org/article/2435b5c0132e4c52a575100a6c99f4b8 |
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ftdoajarticles:oai:doaj.org/article:2435b5c0132e4c52a575100a6c99f4b8 2023-05-15T15:09:50+02:00 Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: an additional mechanism for the hypolipidemic effects of berberine Esfandiar Heidarian Mahmoud Rafieian-Kopaei Abolfazle Khoshdel Morteza Bakhshesh 2014-05-01T00:00:00Z https://doi.org/10.12980/APJTB.4.2014C474 https://doaj.org/article/2435b5c0132e4c52a575100a6c99f4b8 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115303063 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.2014C474 https://doaj.org/article/2435b5c0132e4c52a575100a6c99f4b8 Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss S1, Pp S429-S435 (2014) Atherogenic index Flavonoid Fatty liver Lipid profile Lipogenic diet Oxidative stress Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2014 ftdoajarticles https://doi.org/10.12980/APJTB.4.2014C474 2022-12-31T14:23:19Z Objective: To evaluate the effects of berberine (BBR) on the liver phosphatidate phosphohydrolase (PAP) and plasma lipids in rats fed on high lipogenic and normal diet. Methods: Forty rats were randomly divided into 5 groups. Group I (control) received standard diet. Group II received standard diet plus 90 mg/kg BBR and Groups IV received lipogenic diet (containing sunflower oil, cholesterol and ethanol) without treatment. Groups III and V received lipogenic diet plus 90 mg/kg BBR and 30 mg/kg gemfibrozil, respectively. On Day 60 of the experiment, blood samples were collected and PAP, total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, very low density lipoprotein, malondialdehyde, plasma antioxidant, and liver histopathology assessments were conducted. Results: PAP, plasma triglyceride, total cholesterol, very low density lipoprotein, and malondialdehyde levels decreased significantly (P<0.05) in Group III compared to Group IV (24.94%, 36.11%, 21.18%, 36.86% and 19.59%, respectively). The liver triglyceride and cholesterol in Groups III and V had a remarkable decrease (P<0.001) compared with Group IV (24.94% and 49.13%, respectively). There was a significant reduction (P<0.05) in atherogenic index in Groups III compared with Group IV. Conclusions: These results clearly suggested that BBR could be effective in reducing liver PAP, lipid abnormality, liver triglyceride and lateral side effects of hyperlipidemia. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 4 S429 S435 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Atherogenic index Flavonoid Fatty liver Lipid profile Lipogenic diet Oxidative stress Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Atherogenic index Flavonoid Fatty liver Lipid profile Lipogenic diet Oxidative stress Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Esfandiar Heidarian Mahmoud Rafieian-Kopaei Abolfazle Khoshdel Morteza Bakhshesh Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: an additional mechanism for the hypolipidemic effects of berberine |
topic_facet |
Atherogenic index Flavonoid Fatty liver Lipid profile Lipogenic diet Oxidative stress Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the effects of berberine (BBR) on the liver phosphatidate phosphohydrolase (PAP) and plasma lipids in rats fed on high lipogenic and normal diet. Methods: Forty rats were randomly divided into 5 groups. Group I (control) received standard diet. Group II received standard diet plus 90 mg/kg BBR and Groups IV received lipogenic diet (containing sunflower oil, cholesterol and ethanol) without treatment. Groups III and V received lipogenic diet plus 90 mg/kg BBR and 30 mg/kg gemfibrozil, respectively. On Day 60 of the experiment, blood samples were collected and PAP, total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, very low density lipoprotein, malondialdehyde, plasma antioxidant, and liver histopathology assessments were conducted. Results: PAP, plasma triglyceride, total cholesterol, very low density lipoprotein, and malondialdehyde levels decreased significantly (P<0.05) in Group III compared to Group IV (24.94%, 36.11%, 21.18%, 36.86% and 19.59%, respectively). The liver triglyceride and cholesterol in Groups III and V had a remarkable decrease (P<0.001) compared with Group IV (24.94% and 49.13%, respectively). There was a significant reduction (P<0.05) in atherogenic index in Groups III compared with Group IV. Conclusions: These results clearly suggested that BBR could be effective in reducing liver PAP, lipid abnormality, liver triglyceride and lateral side effects of hyperlipidemia. |
format |
Article in Journal/Newspaper |
author |
Esfandiar Heidarian Mahmoud Rafieian-Kopaei Abolfazle Khoshdel Morteza Bakhshesh |
author_facet |
Esfandiar Heidarian Mahmoud Rafieian-Kopaei Abolfazle Khoshdel Morteza Bakhshesh |
author_sort |
Esfandiar Heidarian |
title |
Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: an additional mechanism for the hypolipidemic effects of berberine |
title_short |
Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: an additional mechanism for the hypolipidemic effects of berberine |
title_full |
Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: an additional mechanism for the hypolipidemic effects of berberine |
title_fullStr |
Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: an additional mechanism for the hypolipidemic effects of berberine |
title_full_unstemmed |
Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: an additional mechanism for the hypolipidemic effects of berberine |
title_sort |
metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: an additional mechanism for the hypolipidemic effects of berberine |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2014 |
url |
https://doi.org/10.12980/APJTB.4.2014C474 https://doaj.org/article/2435b5c0132e4c52a575100a6c99f4b8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss S1, Pp S429-S435 (2014) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115303063 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.2014C474 https://doaj.org/article/2435b5c0132e4c52a575100a6c99f4b8 |
op_doi |
https://doi.org/10.12980/APJTB.4.2014C474 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
4 |
container_start_page |
S429 |
op_container_end_page |
S435 |
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1766340938082287616 |