Molecular identification and antifungal susceptibility profiles of Candida parapsilosis complex species isolated from culture collection of clinical samples
AbstractINTRODUCTION:Candida parapsilosis is a common yeast species found in cases of onychomycosis and candidemia associated with infected intravascular devices. In this study, we differentiated Candida parapsilosis sensu stricto, Candida orthopsilosis , and Candida metapsilosis from a culture coll...
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ftdoajarticles:oai:doaj.org/article:23b580ec3c704fa091d764ba04683bcc 2023-05-15T15:11:17+02:00 Molecular identification and antifungal susceptibility profiles of Candida parapsilosis complex species isolated from culture collection of clinical samples Fábio Silvestre Ataides Carolina Rodrigues Costa Lúcia Kioko Hasimoto e Souza Orionalda deFátima Lisboa Fernandes Rosália Santos Amorim Jesuino Maria do Rosário Rodrigues Silva 2015-08-01T00:00:00Z https://doi.org/10.1590/0037-8682-0120-2015 https://doaj.org/article/23b580ec3c704fa091d764ba04683bcc EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000400454&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0120-2015 https://doaj.org/article/23b580ec3c704fa091d764ba04683bcc Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 4, Pp 454-459 (2015) Candida parapsilosis In vitro antifungal susceptibility Candidemia Onychomycosis Arctic medicine. Tropical medicine RC955-962 article 2015 ftdoajarticles https://doi.org/10.1590/0037-8682-0120-2015 2022-12-30T23:08:09Z AbstractINTRODUCTION:Candida parapsilosis is a common yeast species found in cases of onychomycosis and candidemia associated with infected intravascular devices. In this study, we differentiated Candida parapsilosis sensu stricto, Candida orthopsilosis , and Candida metapsilosis from a culture collection containing blood and subungual scraping samples. Furthermore, we assessed the in vitro antifungal susceptibility of these species to fluconazole, itraconazole, voriconazole, posaconazole, amphotericin B, and caspofungin.METHODS:Differentiation of C. parapsilosis complex species was performed by amplification of the secondary alcohol dehydrogenase (SADH) gene and digestion by the restriction enzyme Ban I. All isolates were evaluated for the determination of minimal inhibitory concentrations using Etest, a method for antifungal susceptibility testing.RESULTS:Among the 87 isolates, 78 (89.7%) were identified as C. parapsilosis sensu stricto , five (5.7%) were identified as C. orthopsilosis , and four (4.6%) were identified as C. metapsilosis . Analysis of antifungal susceptibility showed that C. parapsilosis sensu strictoisolates were less susceptible to amphotericin B and itraconazole. One C. parapsilosis sensu stricto isolate was resistant to amphotericin B and itraconazole. Moreover, 10.2% of C. parapsilosis sensu stricto isolates were resistant to caspofungin. Two C. parapsilosis sensu strictoisolates and one C. metapsilosis isolate were susceptible to fluconazole in a dose-dependent manner.CONCLUSIONS:We reported the first molecular identification of C. parapsilosiscomplex species in State of Goiás, Brazil. Additionally, we showed that although the three species exhibited differences in antifungal susceptibility profiles, the primary susceptibility of this species was to caspofungin. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 48 4 454 459 |
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Candida parapsilosis In vitro antifungal susceptibility Candidemia Onychomycosis Arctic medicine. Tropical medicine RC955-962 |
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Candida parapsilosis In vitro antifungal susceptibility Candidemia Onychomycosis Arctic medicine. Tropical medicine RC955-962 Fábio Silvestre Ataides Carolina Rodrigues Costa Lúcia Kioko Hasimoto e Souza Orionalda deFátima Lisboa Fernandes Rosália Santos Amorim Jesuino Maria do Rosário Rodrigues Silva Molecular identification and antifungal susceptibility profiles of Candida parapsilosis complex species isolated from culture collection of clinical samples |
topic_facet |
Candida parapsilosis In vitro antifungal susceptibility Candidemia Onychomycosis Arctic medicine. Tropical medicine RC955-962 |
description |
AbstractINTRODUCTION:Candida parapsilosis is a common yeast species found in cases of onychomycosis and candidemia associated with infected intravascular devices. In this study, we differentiated Candida parapsilosis sensu stricto, Candida orthopsilosis , and Candida metapsilosis from a culture collection containing blood and subungual scraping samples. Furthermore, we assessed the in vitro antifungal susceptibility of these species to fluconazole, itraconazole, voriconazole, posaconazole, amphotericin B, and caspofungin.METHODS:Differentiation of C. parapsilosis complex species was performed by amplification of the secondary alcohol dehydrogenase (SADH) gene and digestion by the restriction enzyme Ban I. All isolates were evaluated for the determination of minimal inhibitory concentrations using Etest, a method for antifungal susceptibility testing.RESULTS:Among the 87 isolates, 78 (89.7%) were identified as C. parapsilosis sensu stricto , five (5.7%) were identified as C. orthopsilosis , and four (4.6%) were identified as C. metapsilosis . Analysis of antifungal susceptibility showed that C. parapsilosis sensu strictoisolates were less susceptible to amphotericin B and itraconazole. One C. parapsilosis sensu stricto isolate was resistant to amphotericin B and itraconazole. Moreover, 10.2% of C. parapsilosis sensu stricto isolates were resistant to caspofungin. Two C. parapsilosis sensu strictoisolates and one C. metapsilosis isolate were susceptible to fluconazole in a dose-dependent manner.CONCLUSIONS:We reported the first molecular identification of C. parapsilosiscomplex species in State of Goiás, Brazil. Additionally, we showed that although the three species exhibited differences in antifungal susceptibility profiles, the primary susceptibility of this species was to caspofungin. |
format |
Article in Journal/Newspaper |
author |
Fábio Silvestre Ataides Carolina Rodrigues Costa Lúcia Kioko Hasimoto e Souza Orionalda deFátima Lisboa Fernandes Rosália Santos Amorim Jesuino Maria do Rosário Rodrigues Silva |
author_facet |
Fábio Silvestre Ataides Carolina Rodrigues Costa Lúcia Kioko Hasimoto e Souza Orionalda deFátima Lisboa Fernandes Rosália Santos Amorim Jesuino Maria do Rosário Rodrigues Silva |
author_sort |
Fábio Silvestre Ataides |
title |
Molecular identification and antifungal susceptibility profiles of Candida parapsilosis complex species isolated from culture collection of clinical samples |
title_short |
Molecular identification and antifungal susceptibility profiles of Candida parapsilosis complex species isolated from culture collection of clinical samples |
title_full |
Molecular identification and antifungal susceptibility profiles of Candida parapsilosis complex species isolated from culture collection of clinical samples |
title_fullStr |
Molecular identification and antifungal susceptibility profiles of Candida parapsilosis complex species isolated from culture collection of clinical samples |
title_full_unstemmed |
Molecular identification and antifungal susceptibility profiles of Candida parapsilosis complex species isolated from culture collection of clinical samples |
title_sort |
molecular identification and antifungal susceptibility profiles of candida parapsilosis complex species isolated from culture collection of clinical samples |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2015 |
url |
https://doi.org/10.1590/0037-8682-0120-2015 https://doaj.org/article/23b580ec3c704fa091d764ba04683bcc |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 4, Pp 454-459 (2015) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000400454&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0120-2015 https://doaj.org/article/23b580ec3c704fa091d764ba04683bcc |
op_doi |
https://doi.org/10.1590/0037-8682-0120-2015 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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48 |
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454 |
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459 |
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