Are respiratory complications of Plasmodium vivax malaria an underestimated problem?
Abstract Background Respiratory complications are uncommon, but often life-threatening features of Plasmodium vivax malaria. This study aimed to estimate the prevalence and lethality associated with such complications among P. vivax malaria patients in a tertiary hospital in the Western Brazilian Am...
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ftdoajarticles:oai:doaj.org/article:23b3c740b044435b944c2988d2f4d306 2023-05-15T15:11:19+02:00 Are respiratory complications of Plasmodium vivax malaria an underestimated problem? Fernando Val Sara Avalos André Alexandre Gomes José Evelio Albornoz Zerpa Gustavo Fontecha André Machado Siqueira Quique Bassat Maria Graças Costa Alecrim Wuelton Marcelo Monteiro Marcus Vinícius Guimarães Lacerda 2017-12-01T00:00:00Z https://doi.org/10.1186/s12936-017-2143-y https://doaj.org/article/23b3c740b044435b944c2988d2f4d306 EN eng BMC http://link.springer.com/article/10.1186/s12936-017-2143-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-2143-y 1475-2875 https://doaj.org/article/23b3c740b044435b944c2988d2f4d306 Malaria Journal, Vol 16, Iss 1, Pp 1-16 (2017) Plasmodium vivax Severe malaria Respiratory distress Lung Case fatality Prevalence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2017 ftdoajarticles https://doi.org/10.1186/s12936-017-2143-y 2022-12-31T13:44:28Z Abstract Background Respiratory complications are uncommon, but often life-threatening features of Plasmodium vivax malaria. This study aimed to estimate the prevalence and lethality associated with such complications among P. vivax malaria patients in a tertiary hospital in the Western Brazilian Amazon, and to identify variables associated with severe respiratory complications, intensive care need and death. Medical records from 2009 to 2016 were reviewed aiming to identify all patients diagnosed with P. vivax malaria and respiratory complications. Prevalence, lethality and risk factors associated with WHO defined respiratory complications, intensive care need and death were assessed. Results A total of 587 vivax malaria patients were hospitalized during the study period. Thirty (5.1%) developed respiratory complications. Thirteen (43.3%) developed severe respiratory complications, intensive care was required for 12 (40%) patients and 5 (16.6%) died. On admission, anaemia and thrombocytopaenia were common findings, whereas fever was unusual. Patients presented different classes of parasitaemia and six were aparasitaemic on admission. Time to respiratory complications occurred after anti-malarials administration in 18 (60%) patients and progressed very rapidly. Seventeen patients (56.7%) had comorbidities and/or concomitant conditions, which were significantly associated to higher odds of developing severe respiratory complications, need for intensive care and death (p < 0.05). Conclusion Respiratory complications were shown to be associated with significant mortality in this population. Patients with comorbidities and/or concomitant conditions require special attention to avoid this potential life-threatening complication. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 16 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Plasmodium vivax Severe malaria Respiratory distress Lung Case fatality Prevalence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Plasmodium vivax Severe malaria Respiratory distress Lung Case fatality Prevalence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Fernando Val Sara Avalos André Alexandre Gomes José Evelio Albornoz Zerpa Gustavo Fontecha André Machado Siqueira Quique Bassat Maria Graças Costa Alecrim Wuelton Marcelo Monteiro Marcus Vinícius Guimarães Lacerda Are respiratory complications of Plasmodium vivax malaria an underestimated problem? |
topic_facet |
Plasmodium vivax Severe malaria Respiratory distress Lung Case fatality Prevalence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Respiratory complications are uncommon, but often life-threatening features of Plasmodium vivax malaria. This study aimed to estimate the prevalence and lethality associated with such complications among P. vivax malaria patients in a tertiary hospital in the Western Brazilian Amazon, and to identify variables associated with severe respiratory complications, intensive care need and death. Medical records from 2009 to 2016 were reviewed aiming to identify all patients diagnosed with P. vivax malaria and respiratory complications. Prevalence, lethality and risk factors associated with WHO defined respiratory complications, intensive care need and death were assessed. Results A total of 587 vivax malaria patients were hospitalized during the study period. Thirty (5.1%) developed respiratory complications. Thirteen (43.3%) developed severe respiratory complications, intensive care was required for 12 (40%) patients and 5 (16.6%) died. On admission, anaemia and thrombocytopaenia were common findings, whereas fever was unusual. Patients presented different classes of parasitaemia and six were aparasitaemic on admission. Time to respiratory complications occurred after anti-malarials administration in 18 (60%) patients and progressed very rapidly. Seventeen patients (56.7%) had comorbidities and/or concomitant conditions, which were significantly associated to higher odds of developing severe respiratory complications, need for intensive care and death (p < 0.05). Conclusion Respiratory complications were shown to be associated with significant mortality in this population. Patients with comorbidities and/or concomitant conditions require special attention to avoid this potential life-threatening complication. |
format |
Article in Journal/Newspaper |
author |
Fernando Val Sara Avalos André Alexandre Gomes José Evelio Albornoz Zerpa Gustavo Fontecha André Machado Siqueira Quique Bassat Maria Graças Costa Alecrim Wuelton Marcelo Monteiro Marcus Vinícius Guimarães Lacerda |
author_facet |
Fernando Val Sara Avalos André Alexandre Gomes José Evelio Albornoz Zerpa Gustavo Fontecha André Machado Siqueira Quique Bassat Maria Graças Costa Alecrim Wuelton Marcelo Monteiro Marcus Vinícius Guimarães Lacerda |
author_sort |
Fernando Val |
title |
Are respiratory complications of Plasmodium vivax malaria an underestimated problem? |
title_short |
Are respiratory complications of Plasmodium vivax malaria an underestimated problem? |
title_full |
Are respiratory complications of Plasmodium vivax malaria an underestimated problem? |
title_fullStr |
Are respiratory complications of Plasmodium vivax malaria an underestimated problem? |
title_full_unstemmed |
Are respiratory complications of Plasmodium vivax malaria an underestimated problem? |
title_sort |
are respiratory complications of plasmodium vivax malaria an underestimated problem? |
publisher |
BMC |
publishDate |
2017 |
url |
https://doi.org/10.1186/s12936-017-2143-y https://doaj.org/article/23b3c740b044435b944c2988d2f4d306 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 16, Iss 1, Pp 1-16 (2017) |
op_relation |
http://link.springer.com/article/10.1186/s12936-017-2143-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-2143-y 1475-2875 https://doaj.org/article/23b3c740b044435b944c2988d2f4d306 |
op_doi |
https://doi.org/10.1186/s12936-017-2143-y |
container_title |
Malaria Journal |
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16 |
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1 |
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1766342193337860096 |