N eisseria meningitidis carriage rate, antibiotic susceptibility profile, and associated factors among prisoners at Jimma zonal correction facility in Jimma Town, Southwestern Ethiopia: a cross-sectional study
Abstract Background Neisseria meningitidis causes severe life-threatening meningococcal disease with a case fatality rate of 10–15% even with proper treatment. In Ethiopia, particularly in our study area, inadequate information is found on meningococcal disease. So, this study aimed to assess N. men...
Published in: | Tropical Medicine and Health |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2022
|
Subjects: | |
Online Access: | https://doi.org/10.1186/s41182-022-00462-z https://doaj.org/article/2366d7a4139347bab551b2a08c5e5c5e |
id |
ftdoajarticles:oai:doaj.org/article:2366d7a4139347bab551b2a08c5e5c5e |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:2366d7a4139347bab551b2a08c5e5c5e 2023-05-15T15:16:29+02:00 N eisseria meningitidis carriage rate, antibiotic susceptibility profile, and associated factors among prisoners at Jimma zonal correction facility in Jimma Town, Southwestern Ethiopia: a cross-sectional study Samuel Assefa Alemseged Abdissa Yared Alemu Lencho Girma Degemu Sahlu 2022-09-01T00:00:00Z https://doi.org/10.1186/s41182-022-00462-z https://doaj.org/article/2366d7a4139347bab551b2a08c5e5c5e EN eng BMC https://doi.org/10.1186/s41182-022-00462-z https://doaj.org/toc/1349-4147 doi:10.1186/s41182-022-00462-z 1349-4147 https://doaj.org/article/2366d7a4139347bab551b2a08c5e5c5e Tropical Medicine and Health, Vol 50, Iss 1, Pp 1-11 (2022) Meningitides Serogroup Prisoner Pharyngeal Carriage Antibiotic Arctic medicine. Tropical medicine RC955-962 article 2022 ftdoajarticles https://doi.org/10.1186/s41182-022-00462-z 2022-12-30T21:59:06Z Abstract Background Neisseria meningitidis causes severe life-threatening meningococcal disease with a case fatality rate of 10–15% even with proper treatment. In Ethiopia, particularly in our study area, inadequate information is found on meningococcal disease. So, this study aimed to assess N. meningitidis carriage rate, antibiotic susceptibility profile, and associated factors among prisoners in Jimma Town, Southwestern Ethiopia. Methods A cross-sectional study was conducted in Jimma town, Southwest Ethiopia, from May to October 2019. A stratified sampling technique was used and proportional allocation was done. A total of 550 oropharyngeal swabs were collected, processed, isolated, and identified N. meningitidis using standard microbiological techniques. Antibiotics susceptibility test was done for isolates using the disk diffusion method. Data on demographic and associated factors for carriage were collected using a structured questionnaire. Data were summarized using frequency, percentage, graph, and table. A logistic regression model was used to see the association between the dependent and independent variables. Variables with a p-value < 0.25 during bivariate analysis were included in multivariate analysis to identify factors significantly associated with the meningococcal carriage and, a p-value < 0.05 was considered statistically significant. Result Out of the 550 study participants, 76(13.8%) with (CI: 7.20–18.20) were found carriers of N meningitidis. The predominant isolates were non-serogroupable 26(34.2%) and serogroup W/Y 22(28.9%), respectively. N. meningitidis isolates showed highest sensitivity to chloramphenicol 74(97.4%). Meningococcal carriage rate was significantly associated with being age group of 16–20 years; having respiratory symptoms within 3 months and active cigarette smoking within 3 months. Conclusions The majority of participants harbor most of the serogroups responsible for invasive cases of meningococcal disease. Respiratory symptoms, active cigarette smoking, and age ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Tropical Medicine and Health 50 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Meningitides Serogroup Prisoner Pharyngeal Carriage Antibiotic Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Meningitides Serogroup Prisoner Pharyngeal Carriage Antibiotic Arctic medicine. Tropical medicine RC955-962 Samuel Assefa Alemseged Abdissa Yared Alemu Lencho Girma Degemu Sahlu N eisseria meningitidis carriage rate, antibiotic susceptibility profile, and associated factors among prisoners at Jimma zonal correction facility in Jimma Town, Southwestern Ethiopia: a cross-sectional study |
topic_facet |
Meningitides Serogroup Prisoner Pharyngeal Carriage Antibiotic Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background Neisseria meningitidis causes severe life-threatening meningococcal disease with a case fatality rate of 10–15% even with proper treatment. In Ethiopia, particularly in our study area, inadequate information is found on meningococcal disease. So, this study aimed to assess N. meningitidis carriage rate, antibiotic susceptibility profile, and associated factors among prisoners in Jimma Town, Southwestern Ethiopia. Methods A cross-sectional study was conducted in Jimma town, Southwest Ethiopia, from May to October 2019. A stratified sampling technique was used and proportional allocation was done. A total of 550 oropharyngeal swabs were collected, processed, isolated, and identified N. meningitidis using standard microbiological techniques. Antibiotics susceptibility test was done for isolates using the disk diffusion method. Data on demographic and associated factors for carriage were collected using a structured questionnaire. Data were summarized using frequency, percentage, graph, and table. A logistic regression model was used to see the association between the dependent and independent variables. Variables with a p-value < 0.25 during bivariate analysis were included in multivariate analysis to identify factors significantly associated with the meningococcal carriage and, a p-value < 0.05 was considered statistically significant. Result Out of the 550 study participants, 76(13.8%) with (CI: 7.20–18.20) were found carriers of N meningitidis. The predominant isolates were non-serogroupable 26(34.2%) and serogroup W/Y 22(28.9%), respectively. N. meningitidis isolates showed highest sensitivity to chloramphenicol 74(97.4%). Meningococcal carriage rate was significantly associated with being age group of 16–20 years; having respiratory symptoms within 3 months and active cigarette smoking within 3 months. Conclusions The majority of participants harbor most of the serogroups responsible for invasive cases of meningococcal disease. Respiratory symptoms, active cigarette smoking, and age ... |
format |
Article in Journal/Newspaper |
author |
Samuel Assefa Alemseged Abdissa Yared Alemu Lencho Girma Degemu Sahlu |
author_facet |
Samuel Assefa Alemseged Abdissa Yared Alemu Lencho Girma Degemu Sahlu |
author_sort |
Samuel Assefa |
title |
N eisseria meningitidis carriage rate, antibiotic susceptibility profile, and associated factors among prisoners at Jimma zonal correction facility in Jimma Town, Southwestern Ethiopia: a cross-sectional study |
title_short |
N eisseria meningitidis carriage rate, antibiotic susceptibility profile, and associated factors among prisoners at Jimma zonal correction facility in Jimma Town, Southwestern Ethiopia: a cross-sectional study |
title_full |
N eisseria meningitidis carriage rate, antibiotic susceptibility profile, and associated factors among prisoners at Jimma zonal correction facility in Jimma Town, Southwestern Ethiopia: a cross-sectional study |
title_fullStr |
N eisseria meningitidis carriage rate, antibiotic susceptibility profile, and associated factors among prisoners at Jimma zonal correction facility in Jimma Town, Southwestern Ethiopia: a cross-sectional study |
title_full_unstemmed |
N eisseria meningitidis carriage rate, antibiotic susceptibility profile, and associated factors among prisoners at Jimma zonal correction facility in Jimma Town, Southwestern Ethiopia: a cross-sectional study |
title_sort |
n eisseria meningitidis carriage rate, antibiotic susceptibility profile, and associated factors among prisoners at jimma zonal correction facility in jimma town, southwestern ethiopia: a cross-sectional study |
publisher |
BMC |
publishDate |
2022 |
url |
https://doi.org/10.1186/s41182-022-00462-z https://doaj.org/article/2366d7a4139347bab551b2a08c5e5c5e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Tropical Medicine and Health, Vol 50, Iss 1, Pp 1-11 (2022) |
op_relation |
https://doi.org/10.1186/s41182-022-00462-z https://doaj.org/toc/1349-4147 doi:10.1186/s41182-022-00462-z 1349-4147 https://doaj.org/article/2366d7a4139347bab551b2a08c5e5c5e |
op_doi |
https://doi.org/10.1186/s41182-022-00462-z |
container_title |
Tropical Medicine and Health |
container_volume |
50 |
container_issue |
1 |
_version_ |
1766346785419165696 |