A pre-vaccine exploratory survey of SARS-CoV-2 humoral immunity among Egyptian general population
Abstract Background Population-based studies on COVID-19 have important implications for modeling the pandemic and determining vaccination policies. Limited data are available from such surveys in Egypt. Methods This cross-sectional was conducted throughout the period between January and June 2021,...
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ftdoajarticles:oai:doaj.org/article:2356248e8d1f4981813b3a69f917ac21 2023-05-15T15:12:44+02:00 A pre-vaccine exploratory survey of SARS-CoV-2 humoral immunity among Egyptian general population Engy Mohamed El-Ghitany Shehata Farag Azza Galal Farghaly Mona H. Hashish Mahmoud A. Hassaan Eman A. Omran 2022-08-01T00:00:00Z https://doi.org/10.1186/s41182-022-00448-x https://doaj.org/article/2356248e8d1f4981813b3a69f917ac21 EN eng BMC https://doi.org/10.1186/s41182-022-00448-x https://doaj.org/toc/1349-4147 doi:10.1186/s41182-022-00448-x 1349-4147 https://doaj.org/article/2356248e8d1f4981813b3a69f917ac21 Tropical Medicine and Health, Vol 50, Iss 1, Pp 1-10 (2022) SARS-CoV-2 Seroprevalence Anti-spike Immune-response Arctic medicine. Tropical medicine RC955-962 article 2022 ftdoajarticles https://doi.org/10.1186/s41182-022-00448-x 2022-12-31T00:55:33Z Abstract Background Population-based studies on COVID-19 have important implications for modeling the pandemic and determining vaccination policies. Limited data are available from such surveys in Egypt. Methods This cross-sectional was conducted throughout the period between January and June 2021, which coincided with the second and third waves of the COVID-19 pandemic in Egypt. At that time, vaccines against COVID-19 were not available to the general population. The study was carried out in eight Egyptian governorates and included 2360 participants, who were recruited through a multistage stratified cluster sample technique, based on gender, age, and district followed by a random sample within each district. Socio-demographic data were recorded and serum samples were collected and tested for SARS-Co-V2 spike (S) antibodies. Results The overall adjusted prevalence of anti-S was 46.3% (95% CI 44.2–48.3%), with significant differences between governorates. Factors associated with anti-S seropositivity were: being female (p = 0.001), living in a rural area (p = 0.008), and reporting a history of COVID-19 infection (p = 0.001). Higher medians of anti-S titers were significantly associated with: extremes of age (p < 0.001), living in urban areas, having primary education (p = 0.009), and reporting a history of COVID-19 infection, especially if based on chest CT or PCR (p < 0.001). Conclusions High seroprevalence rates indicate increased COVID-19 infection and immune response among a considerable percentage of the community. Age, gender, residence, educational level, and previous PCR-confirmed COVID-19 infections were all determinants of the immune response. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Tropical Medicine and Health 50 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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SARS-CoV-2 Seroprevalence Anti-spike Immune-response Arctic medicine. Tropical medicine RC955-962 |
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SARS-CoV-2 Seroprevalence Anti-spike Immune-response Arctic medicine. Tropical medicine RC955-962 Engy Mohamed El-Ghitany Shehata Farag Azza Galal Farghaly Mona H. Hashish Mahmoud A. Hassaan Eman A. Omran A pre-vaccine exploratory survey of SARS-CoV-2 humoral immunity among Egyptian general population |
topic_facet |
SARS-CoV-2 Seroprevalence Anti-spike Immune-response Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background Population-based studies on COVID-19 have important implications for modeling the pandemic and determining vaccination policies. Limited data are available from such surveys in Egypt. Methods This cross-sectional was conducted throughout the period between January and June 2021, which coincided with the second and third waves of the COVID-19 pandemic in Egypt. At that time, vaccines against COVID-19 were not available to the general population. The study was carried out in eight Egyptian governorates and included 2360 participants, who were recruited through a multistage stratified cluster sample technique, based on gender, age, and district followed by a random sample within each district. Socio-demographic data were recorded and serum samples were collected and tested for SARS-Co-V2 spike (S) antibodies. Results The overall adjusted prevalence of anti-S was 46.3% (95% CI 44.2–48.3%), with significant differences between governorates. Factors associated with anti-S seropositivity were: being female (p = 0.001), living in a rural area (p = 0.008), and reporting a history of COVID-19 infection (p = 0.001). Higher medians of anti-S titers were significantly associated with: extremes of age (p < 0.001), living in urban areas, having primary education (p = 0.009), and reporting a history of COVID-19 infection, especially if based on chest CT or PCR (p < 0.001). Conclusions High seroprevalence rates indicate increased COVID-19 infection and immune response among a considerable percentage of the community. Age, gender, residence, educational level, and previous PCR-confirmed COVID-19 infections were all determinants of the immune response. |
format |
Article in Journal/Newspaper |
author |
Engy Mohamed El-Ghitany Shehata Farag Azza Galal Farghaly Mona H. Hashish Mahmoud A. Hassaan Eman A. Omran |
author_facet |
Engy Mohamed El-Ghitany Shehata Farag Azza Galal Farghaly Mona H. Hashish Mahmoud A. Hassaan Eman A. Omran |
author_sort |
Engy Mohamed El-Ghitany |
title |
A pre-vaccine exploratory survey of SARS-CoV-2 humoral immunity among Egyptian general population |
title_short |
A pre-vaccine exploratory survey of SARS-CoV-2 humoral immunity among Egyptian general population |
title_full |
A pre-vaccine exploratory survey of SARS-CoV-2 humoral immunity among Egyptian general population |
title_fullStr |
A pre-vaccine exploratory survey of SARS-CoV-2 humoral immunity among Egyptian general population |
title_full_unstemmed |
A pre-vaccine exploratory survey of SARS-CoV-2 humoral immunity among Egyptian general population |
title_sort |
pre-vaccine exploratory survey of sars-cov-2 humoral immunity among egyptian general population |
publisher |
BMC |
publishDate |
2022 |
url |
https://doi.org/10.1186/s41182-022-00448-x https://doaj.org/article/2356248e8d1f4981813b3a69f917ac21 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Tropical Medicine and Health, Vol 50, Iss 1, Pp 1-10 (2022) |
op_relation |
https://doi.org/10.1186/s41182-022-00448-x https://doaj.org/toc/1349-4147 doi:10.1186/s41182-022-00448-x 1349-4147 https://doaj.org/article/2356248e8d1f4981813b3a69f917ac21 |
op_doi |
https://doi.org/10.1186/s41182-022-00448-x |
container_title |
Tropical Medicine and Health |
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50 |
container_issue |
1 |
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1766343372134416384 |