The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis.
Background Individual helminth infections are ubiquitous in the tropics; geographical overlaps in endemicity and epidemiological reports suggest areas endemic for multiple helminthiases are also burdened with high prevalences of intestinal protozoan infections, malaria, tuberculosis (TB), and human...
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ftdoajarticles:oai:doaj.org/article:23242eee18584deb882ea00ccd170589 2023-05-15T15:13:33+02:00 The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis. Rose E Donohue Zoë K Cross Edwin Michael 2019-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007455 https://doaj.org/article/23242eee18584deb882ea00ccd170589 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007455 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007455 https://doaj.org/article/23242eee18584deb882ea00ccd170589 PLoS Neglected Tropical Diseases, Vol 13, Iss 6, p e0007455 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007455 2022-12-31T06:00:22Z Background Individual helminth infections are ubiquitous in the tropics; geographical overlaps in endemicity and epidemiological reports suggest areas endemic for multiple helminthiases are also burdened with high prevalences of intestinal protozoan infections, malaria, tuberculosis (TB), and human immunodeficiency virus (HIV). Despite this, pathogens tend to be studied in isolation, and there remains a need for a better understanding of the community ecology and health consequences of helminth polyparasitism to inform the design of effective parasite control programs. Methodology We performed meta-analyses to (i) evaluate the commonality of polyparasitism for helminth-helminth, helminth-intestinal protozoa, helminth-malaria, helminth-TB, and helminth-HIV co-infections, (ii) assess the potential for interspecies interactions among helminth-helminth and helminth-intestinal protozoan infections, and (iii) determine the presence and magnitude of association between specific parasite pairs. Additionally, we conducted a review of reported health consequences of multiply-infected individuals compared to singly- or not multiply-infected individuals. Principal findings We found that helminth-helminth and helminth-intestinal protozoan multiple infections were significantly more common than single infections, while individuals with malaria, TB, and HIV were more likely to be singly-infected with these infections than co-infected with at least one helminth. Most observed species density distributions significantly differed from the expected distributions, suggesting the potential presence of interspecies interactions. All significant associations between parasite pairs were positive in direction, irrespective of the combination of pathogens. Polyparasitized individuals largely exhibited lower hemoglobin levels and higher anemia prevalence, while the differences in growth-related variables were mostly statistically insignificant. Conclusions Our findings confirm that helminth polyparasitism and co-infection with major ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 6 e0007455 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Rose E Donohue Zoë K Cross Edwin Michael The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Individual helminth infections are ubiquitous in the tropics; geographical overlaps in endemicity and epidemiological reports suggest areas endemic for multiple helminthiases are also burdened with high prevalences of intestinal protozoan infections, malaria, tuberculosis (TB), and human immunodeficiency virus (HIV). Despite this, pathogens tend to be studied in isolation, and there remains a need for a better understanding of the community ecology and health consequences of helminth polyparasitism to inform the design of effective parasite control programs. Methodology We performed meta-analyses to (i) evaluate the commonality of polyparasitism for helminth-helminth, helminth-intestinal protozoa, helminth-malaria, helminth-TB, and helminth-HIV co-infections, (ii) assess the potential for interspecies interactions among helminth-helminth and helminth-intestinal protozoan infections, and (iii) determine the presence and magnitude of association between specific parasite pairs. Additionally, we conducted a review of reported health consequences of multiply-infected individuals compared to singly- or not multiply-infected individuals. Principal findings We found that helminth-helminth and helminth-intestinal protozoan multiple infections were significantly more common than single infections, while individuals with malaria, TB, and HIV were more likely to be singly-infected with these infections than co-infected with at least one helminth. Most observed species density distributions significantly differed from the expected distributions, suggesting the potential presence of interspecies interactions. All significant associations between parasite pairs were positive in direction, irrespective of the combination of pathogens. Polyparasitized individuals largely exhibited lower hemoglobin levels and higher anemia prevalence, while the differences in growth-related variables were mostly statistically insignificant. Conclusions Our findings confirm that helminth polyparasitism and co-infection with major ... |
format |
Article in Journal/Newspaper |
author |
Rose E Donohue Zoë K Cross Edwin Michael |
author_facet |
Rose E Donohue Zoë K Cross Edwin Michael |
author_sort |
Rose E Donohue |
title |
The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis. |
title_short |
The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis. |
title_full |
The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis. |
title_fullStr |
The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis. |
title_full_unstemmed |
The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis. |
title_sort |
extent, nature, and pathogenic consequences of helminth polyparasitism in humans: a meta-analysis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007455 https://doaj.org/article/23242eee18584deb882ea00ccd170589 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 6, p e0007455 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007455 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007455 https://doaj.org/article/23242eee18584deb882ea00ccd170589 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007455 |
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PLOS Neglected Tropical Diseases |
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13 |
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6 |
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e0007455 |
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