Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Caio Vinicius Botelho Brito, Érika Dayane Leal Rodrigues, Fernanda Monik Silva Martins, Lavinia Dias Tavares, André Luis de Sousa Nogueira Lima, Lucas Carvalho Ferreira, Carlos Junior Lopes Santana, João Augusto Gomes de Souza Monteiro de Brito, Lívia Medeiros Neves Casseb, José Antonio Picanço Diniz Junior
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 2021
• Subjects: Rabies; Rabies virus; Tetrahydrobiopterin; Blood-Brain Barrier; Interleukin-6; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/s1678-9946202163028; https://doaj.org/article/230a04e264ab4731af423ce8e20b6ab9

ABSTRACT Currently, the Milwaukee protocol presents healing results in human beings affected by the rabies virus. However, there are many points to clarify on the action of drugs and the immune mechanism involved in the evolution of the disease. One of the drugs used is biopterin, which is an important cofactor for nitric oxide, important for preventing vasospasm. Thus, we describe the effect of biopterin on some inflammatory factors in a rabies virus infection developed in an animal model. The immunological mediators studied in animals infected with rabies virus submitted to doses of sapropterin were Anti-RABV, IL-6, IL-2, IL-17a, INF-gamma and Anti-iNOS. It is suggested that the medication in the context of a RABV infection already installed, had the effect of modulating the inflammatory mechanisms mainly linked to the permeability of the blood-brain barrier and the migration of cytotoxic cells.