Genetic diversity of the cestode Echinococcus multilocularis in red foxes at a continental scale in Europe.
Alveolar echinococcosis (AE) is a severe helminth disease affecting humans, which is caused by the fox tapeworm Echinococcus multilocularis. AE represents a serious public health issue in larger regions of China, Siberia, and other regions in Asia. In Europe, a significant increase in prevalence sin...
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ftdoajarticles:oai:doaj.org/article:22ed9d55b1624116bbce05258f74e8d4 2023-05-15T15:11:16+02:00 Genetic diversity of the cestode Echinococcus multilocularis in red foxes at a continental scale in Europe. Jenny Knapp Jean-Mathieu Bart Patrick Giraudoux Marie-Louise Glowatzki Isabelle Breyer Francis Raoul Peter Deplazes Georg Duscher Karel Martinek Pavol Dubinsky Marie-Hélène Guislain Florence Cliquet Thomas Romig Andrzej Malczewski Bruno Gottstein Renaud Piarroux 2009-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000452 https://doaj.org/article/22ed9d55b1624116bbce05258f74e8d4 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2685985?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000452 https://doaj.org/article/22ed9d55b1624116bbce05258f74e8d4 PLoS Neglected Tropical Diseases, Vol 3, Iss 6, p e452 (2009) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2009 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000452 2022-12-31T09:26:49Z Alveolar echinococcosis (AE) is a severe helminth disease affecting humans, which is caused by the fox tapeworm Echinococcus multilocularis. AE represents a serious public health issue in larger regions of China, Siberia, and other regions in Asia. In Europe, a significant increase in prevalence since the 1990s is not only affecting the historically documented endemic area north of the Alps but more recently also neighbouring regions previously not known to be endemic. The genetic diversity of the parasite population and respective distribution in Europe have now been investigated in view of generating a fine-tuned map of parasite variants occurring in Europe. This approach may serve as a model to study the parasite at a worldwide level.The genetic diversity of E. multilocularis was assessed based upon the tandemly repeated microsatellite marker EmsB in association with matching fox host geographical positions. Our study demonstrated a higher genetic diversity in the endemic areas north of the Alps when compared to other areas.The study of the spatial distribution of E. multilocularis in Europe, based on 32 genetic clusters, suggests that Europe can be considered as a unique global focus of E. multilocularis, which can be schematically drawn as a central core located in Switzerland and Jura Swabe flanked by neighbouring regions where the parasite exhibits a lower genetic diversity. The transmission of the parasite into peripheral regions is governed by a "mainland-island" system. Moreover, the presence of similar genetic profiles in both zones indicated a founder event. Article in Journal/Newspaper Arctic Siberia Directory of Open Access Journals: DOAJ Articles Arctic Jura ENVELOPE(13.501,13.501,68.062,68.062) PLoS Neglected Tropical Diseases 3 6 e452 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jenny Knapp Jean-Mathieu Bart Patrick Giraudoux Marie-Louise Glowatzki Isabelle Breyer Francis Raoul Peter Deplazes Georg Duscher Karel Martinek Pavol Dubinsky Marie-Hélène Guislain Florence Cliquet Thomas Romig Andrzej Malczewski Bruno Gottstein Renaud Piarroux Genetic diversity of the cestode Echinococcus multilocularis in red foxes at a continental scale in Europe. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Alveolar echinococcosis (AE) is a severe helminth disease affecting humans, which is caused by the fox tapeworm Echinococcus multilocularis. AE represents a serious public health issue in larger regions of China, Siberia, and other regions in Asia. In Europe, a significant increase in prevalence since the 1990s is not only affecting the historically documented endemic area north of the Alps but more recently also neighbouring regions previously not known to be endemic. The genetic diversity of the parasite population and respective distribution in Europe have now been investigated in view of generating a fine-tuned map of parasite variants occurring in Europe. This approach may serve as a model to study the parasite at a worldwide level.The genetic diversity of E. multilocularis was assessed based upon the tandemly repeated microsatellite marker EmsB in association with matching fox host geographical positions. Our study demonstrated a higher genetic diversity in the endemic areas north of the Alps when compared to other areas.The study of the spatial distribution of E. multilocularis in Europe, based on 32 genetic clusters, suggests that Europe can be considered as a unique global focus of E. multilocularis, which can be schematically drawn as a central core located in Switzerland and Jura Swabe flanked by neighbouring regions where the parasite exhibits a lower genetic diversity. The transmission of the parasite into peripheral regions is governed by a "mainland-island" system. Moreover, the presence of similar genetic profiles in both zones indicated a founder event. |
format |
Article in Journal/Newspaper |
author |
Jenny Knapp Jean-Mathieu Bart Patrick Giraudoux Marie-Louise Glowatzki Isabelle Breyer Francis Raoul Peter Deplazes Georg Duscher Karel Martinek Pavol Dubinsky Marie-Hélène Guislain Florence Cliquet Thomas Romig Andrzej Malczewski Bruno Gottstein Renaud Piarroux |
author_facet |
Jenny Knapp Jean-Mathieu Bart Patrick Giraudoux Marie-Louise Glowatzki Isabelle Breyer Francis Raoul Peter Deplazes Georg Duscher Karel Martinek Pavol Dubinsky Marie-Hélène Guislain Florence Cliquet Thomas Romig Andrzej Malczewski Bruno Gottstein Renaud Piarroux |
author_sort |
Jenny Knapp |
title |
Genetic diversity of the cestode Echinococcus multilocularis in red foxes at a continental scale in Europe. |
title_short |
Genetic diversity of the cestode Echinococcus multilocularis in red foxes at a continental scale in Europe. |
title_full |
Genetic diversity of the cestode Echinococcus multilocularis in red foxes at a continental scale in Europe. |
title_fullStr |
Genetic diversity of the cestode Echinococcus multilocularis in red foxes at a continental scale in Europe. |
title_full_unstemmed |
Genetic diversity of the cestode Echinococcus multilocularis in red foxes at a continental scale in Europe. |
title_sort |
genetic diversity of the cestode echinococcus multilocularis in red foxes at a continental scale in europe. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2009 |
url |
https://doi.org/10.1371/journal.pntd.0000452 https://doaj.org/article/22ed9d55b1624116bbce05258f74e8d4 |
long_lat |
ENVELOPE(13.501,13.501,68.062,68.062) |
geographic |
Arctic Jura |
geographic_facet |
Arctic Jura |
genre |
Arctic Siberia |
genre_facet |
Arctic Siberia |
op_source |
PLoS Neglected Tropical Diseases, Vol 3, Iss 6, p e452 (2009) |
op_relation |
http://europepmc.org/articles/PMC2685985?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000452 https://doaj.org/article/22ed9d55b1624116bbce05258f74e8d4 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000452 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
3 |
container_issue |
6 |
container_start_page |
e452 |
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1766342147961782272 |