Clinical and parasitological factors in parasite persistence after treatment and clinical cure of cutaneous leishmaniasis.
The determinants of parasite persistence or elimination after treatment and clinical resolution of cutaneous leishmaniasis (CL) are unknown. We investigated clinical and parasitological parameters associated with the presence and viability of Leishmania after treatment and resolution of CL caused by...
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ftdoajarticles:oai:doaj.org/article:22d38178b3bb418e974c903265adf9f9 2023-05-15T15:07:49+02:00 Clinical and parasitological factors in parasite persistence after treatment and clinical cure of cutaneous leishmaniasis. Alvaro J Martínez-Valencia Carlos Frisherald Daza-Rivera Mariana Rosales-Chilama Alexandra Cossio Elkin J Casadiego Rincón Mayur M Desai Nancy Gore Saravia María Adelaida Gómez 2017-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005713 https://doaj.org/article/22d38178b3bb418e974c903265adf9f9 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5526576?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005713 https://doaj.org/article/22d38178b3bb418e974c903265adf9f9 PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005713 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005713 2022-12-31T12:24:11Z The determinants of parasite persistence or elimination after treatment and clinical resolution of cutaneous leishmaniasis (CL) are unknown. We investigated clinical and parasitological parameters associated with the presence and viability of Leishmania after treatment and resolution of CL caused by L. Viannia.Seventy patients who were treated with meglumine antimoniate (n = 38) or miltefosine (n = 32) and cured, were included in this study. Leishmania persistence and viability were determined by detection of kDNA and 7SLRNA transcripts, respectively, before, at the end of treatment (EoT), and 13 weeks after initiation of treatment in lesions and swabs of nasal and tonsillar mucosa.Sixty percent of patients (42/70) had evidence of Leishmania persistence at EoT and 30% (9/30) 13 weeks after treatment initiation. A previous episode of CL was found to be a protective factor for detectable Leishmania persistence (OR: 0.16, 95%CI: 0.03-0.92). kDNA genotyping could not discern differences between parasite populations that persisted and those isolated at diagnosis.Leishmania persist in skin and mucosal tissues in a high proportion of patients who achieved therapeutic cure of CL. This finding prompts assessment of the contribution of persistent infection in transmission and endemicity of CL, and in disease reactivation and protective immunity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 7 e0005713 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Alvaro J Martínez-Valencia Carlos Frisherald Daza-Rivera Mariana Rosales-Chilama Alexandra Cossio Elkin J Casadiego Rincón Mayur M Desai Nancy Gore Saravia María Adelaida Gómez Clinical and parasitological factors in parasite persistence after treatment and clinical cure of cutaneous leishmaniasis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The determinants of parasite persistence or elimination after treatment and clinical resolution of cutaneous leishmaniasis (CL) are unknown. We investigated clinical and parasitological parameters associated with the presence and viability of Leishmania after treatment and resolution of CL caused by L. Viannia.Seventy patients who were treated with meglumine antimoniate (n = 38) or miltefosine (n = 32) and cured, were included in this study. Leishmania persistence and viability were determined by detection of kDNA and 7SLRNA transcripts, respectively, before, at the end of treatment (EoT), and 13 weeks after initiation of treatment in lesions and swabs of nasal and tonsillar mucosa.Sixty percent of patients (42/70) had evidence of Leishmania persistence at EoT and 30% (9/30) 13 weeks after treatment initiation. A previous episode of CL was found to be a protective factor for detectable Leishmania persistence (OR: 0.16, 95%CI: 0.03-0.92). kDNA genotyping could not discern differences between parasite populations that persisted and those isolated at diagnosis.Leishmania persist in skin and mucosal tissues in a high proportion of patients who achieved therapeutic cure of CL. This finding prompts assessment of the contribution of persistent infection in transmission and endemicity of CL, and in disease reactivation and protective immunity. |
format |
Article in Journal/Newspaper |
author |
Alvaro J Martínez-Valencia Carlos Frisherald Daza-Rivera Mariana Rosales-Chilama Alexandra Cossio Elkin J Casadiego Rincón Mayur M Desai Nancy Gore Saravia María Adelaida Gómez |
author_facet |
Alvaro J Martínez-Valencia Carlos Frisherald Daza-Rivera Mariana Rosales-Chilama Alexandra Cossio Elkin J Casadiego Rincón Mayur M Desai Nancy Gore Saravia María Adelaida Gómez |
author_sort |
Alvaro J Martínez-Valencia |
title |
Clinical and parasitological factors in parasite persistence after treatment and clinical cure of cutaneous leishmaniasis. |
title_short |
Clinical and parasitological factors in parasite persistence after treatment and clinical cure of cutaneous leishmaniasis. |
title_full |
Clinical and parasitological factors in parasite persistence after treatment and clinical cure of cutaneous leishmaniasis. |
title_fullStr |
Clinical and parasitological factors in parasite persistence after treatment and clinical cure of cutaneous leishmaniasis. |
title_full_unstemmed |
Clinical and parasitological factors in parasite persistence after treatment and clinical cure of cutaneous leishmaniasis. |
title_sort |
clinical and parasitological factors in parasite persistence after treatment and clinical cure of cutaneous leishmaniasis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005713 https://doaj.org/article/22d38178b3bb418e974c903265adf9f9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005713 (2017) |
op_relation |
http://europepmc.org/articles/PMC5526576?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005713 https://doaj.org/article/22d38178b3bb418e974c903265adf9f9 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005713 |
container_title |
PLOS Neglected Tropical Diseases |
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11 |
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7 |
container_start_page |
e0005713 |
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