A clinico-pathological study of 163 untreated cases of chronic hepatitis C
We performed a clinico-pathological study of 163 untreated cases of chronic hepatitis C. Eighty five percent of the patients were clinically asymptomatic and their physical examinations sbowed unremarkable or minimal changes at the time of the liver biopsy Liver function tests tended to present slig...
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Sociedade Brasileira de Medicina Tropical (SBMT)
1996
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ftdoajarticles:oai:doaj.org/article:22cf0f1c6669461383e58b3cbedc2d30 2023-05-15T15:09:33+02:00 A clinico-pathological study of 163 untreated cases of chronic hepatitis C Joachim Graf Kan Toriyama Hideyo Itakura 1996-02-01T00:00:00Z https://doaj.org/article/22cf0f1c6669461383e58b3cbedc2d30 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821996000100005 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/22cf0f1c6669461383e58b3cbedc2d30 Revista da Sociedade Brasileira de Medicina Tropical, Vol 29, Iss 1, Pp 21-25 (1996) Hepatite crônica C Lesão de dueto biliar Agregado linfóide Histopatologia Chronic hepatitis C Bile duct damage Lymphoid aggregate Histopathology Arctic medicine. Tropical medicine RC955-962 article 1996 ftdoajarticles 2022-12-30T21:39:23Z We performed a clinico-pathological study of 163 untreated cases of chronic hepatitis C. Eighty five percent of the patients were clinically asymptomatic and their physical examinations sbowed unremarkable or minimal changes at the time of the liver biopsy Liver function tests tended to present slight abnormalities, involving mild elevations of the activity of the aminotransferases and gamma-glutamil transferase levels. In spite of these mild abnormalities advanced chronic liver disease ivas histologically detected in eighty nine percent of the patients, mainly showing chronic active hepatitis. The most characteristic histological finding ivas an interlobular bile duct damage which correlated with the presence of tymphoid aggregates in the portal tracts and with the development of fibrosis. Realizou-se estudo clinico-patológico de 163 casos não tratados de hepatite crônica C. A maioria dos pacientes era clinicamente assintomática e seus exames físicos demonstravam alterações inespecíficas ou mínimas por ocasião da biópsia hepática. As provas de função hepática tendiam a apresentar alterações discretas, envolvendo especialmente os níveis séricos das aminotransferases e gama-glutamil transpeptidase. Apesar destas alterações discretas, detectou-se doença hepática crônica histologicamente avançada, consistindo principalmente de hepatite crônica ativa. O achado histológico mais característico foi lesão de dueto biliar interlobular, que se correlacionou com a presença de agregados linfóides nos tratos portais e com o desenvolvimento de fibrose. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic The Portal ENVELOPE(159.167,159.167,-78.100,-78.100) Característico ENVELOPE(-60.167,-60.167,-62.733,-62.733) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Hepatite crônica C Lesão de dueto biliar Agregado linfóide Histopatologia Chronic hepatitis C Bile duct damage Lymphoid aggregate Histopathology Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Hepatite crônica C Lesão de dueto biliar Agregado linfóide Histopatologia Chronic hepatitis C Bile duct damage Lymphoid aggregate Histopathology Arctic medicine. Tropical medicine RC955-962 Joachim Graf Kan Toriyama Hideyo Itakura A clinico-pathological study of 163 untreated cases of chronic hepatitis C |
topic_facet |
Hepatite crônica C Lesão de dueto biliar Agregado linfóide Histopatologia Chronic hepatitis C Bile duct damage Lymphoid aggregate Histopathology Arctic medicine. Tropical medicine RC955-962 |
description |
We performed a clinico-pathological study of 163 untreated cases of chronic hepatitis C. Eighty five percent of the patients were clinically asymptomatic and their physical examinations sbowed unremarkable or minimal changes at the time of the liver biopsy Liver function tests tended to present slight abnormalities, involving mild elevations of the activity of the aminotransferases and gamma-glutamil transferase levels. In spite of these mild abnormalities advanced chronic liver disease ivas histologically detected in eighty nine percent of the patients, mainly showing chronic active hepatitis. The most characteristic histological finding ivas an interlobular bile duct damage which correlated with the presence of tymphoid aggregates in the portal tracts and with the development of fibrosis. Realizou-se estudo clinico-patológico de 163 casos não tratados de hepatite crônica C. A maioria dos pacientes era clinicamente assintomática e seus exames físicos demonstravam alterações inespecíficas ou mínimas por ocasião da biópsia hepática. As provas de função hepática tendiam a apresentar alterações discretas, envolvendo especialmente os níveis séricos das aminotransferases e gama-glutamil transpeptidase. Apesar destas alterações discretas, detectou-se doença hepática crônica histologicamente avançada, consistindo principalmente de hepatite crônica ativa. O achado histológico mais característico foi lesão de dueto biliar interlobular, que se correlacionou com a presença de agregados linfóides nos tratos portais e com o desenvolvimento de fibrose. |
format |
Article in Journal/Newspaper |
author |
Joachim Graf Kan Toriyama Hideyo Itakura |
author_facet |
Joachim Graf Kan Toriyama Hideyo Itakura |
author_sort |
Joachim Graf |
title |
A clinico-pathological study of 163 untreated cases of chronic hepatitis C |
title_short |
A clinico-pathological study of 163 untreated cases of chronic hepatitis C |
title_full |
A clinico-pathological study of 163 untreated cases of chronic hepatitis C |
title_fullStr |
A clinico-pathological study of 163 untreated cases of chronic hepatitis C |
title_full_unstemmed |
A clinico-pathological study of 163 untreated cases of chronic hepatitis C |
title_sort |
clinico-pathological study of 163 untreated cases of chronic hepatitis c |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
1996 |
url |
https://doaj.org/article/22cf0f1c6669461383e58b3cbedc2d30 |
long_lat |
ENVELOPE(159.167,159.167,-78.100,-78.100) ENVELOPE(-60.167,-60.167,-62.733,-62.733) |
geographic |
Arctic The Portal Característico |
geographic_facet |
Arctic The Portal Característico |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 29, Iss 1, Pp 21-25 (1996) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821996000100005 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/22cf0f1c6669461383e58b3cbedc2d30 |
_version_ |
1766340721893179392 |