Pimarane-Type Diterpenes with Anti-Inflammatory Activity from Arctic-Derived Fungus Eutypella sp. D-1
The Arctic-derived fungus Eutypella sp. D-1 can produce numerous secondary metabolites, and some compounds exhibit excellent biological activity. Seven pimarane-type diterpenes, including three new compounds eutypellenone F ( 1 ), libertellenone Y ( 2 ), and libertellenone Z ( 3 ), and four known co...
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ftdoajarticles:oai:doaj.org/article:2287c2f0bf9b4dd39ace93caa3e31d4f 2023-11-12T04:12:26+01:00 Pimarane-Type Diterpenes with Anti-Inflammatory Activity from Arctic-Derived Fungus Eutypella sp. D-1 Yaodong Ning Shi Zhang Te Zheng Yao Xu Song Li Jianpeng Zhang Binghua Jiao Yun Zhang Zengling Ma Xiaoling Lu 2023-10-01T00:00:00Z https://doi.org/10.3390/md21100541 https://doaj.org/article/2287c2f0bf9b4dd39ace93caa3e31d4f EN eng MDPI AG https://www.mdpi.com/1660-3397/21/10/541 https://doaj.org/toc/1660-3397 doi:10.3390/md21100541 1660-3397 https://doaj.org/article/2287c2f0bf9b4dd39ace93caa3e31d4f Marine Drugs, Vol 21, Iss 541, p 541 (2023) Eutypella sp. D-1 diterpene anti-inflammatory zebrafish model Biology (General) QH301-705.5 article 2023 ftdoajarticles https://doi.org/10.3390/md21100541 2023-10-29T00:36:12Z The Arctic-derived fungus Eutypella sp. D-1 can produce numerous secondary metabolites, and some compounds exhibit excellent biological activity. Seven pimarane-type diterpenes, including three new compounds eutypellenone F ( 1 ), libertellenone Y ( 2 ), and libertellenone Z ( 3 ), and four known compounds ( 4 – 7 ), were isolated from fermentation broth of Eutypella sp. D-1 by the OSMAC strategy of adding ethanol as a promoter in the culture medium. Compound 2 has a rare tetrahydrofuran-fused pimarane diterpene skeleton. The anti-inflammatory activity of all compounds was evaluated. Compounds 3 – 6 showed a significant inhibitory effect on cell NO release at 10 μmol/L by in vitro experiments, of which 3 – 5 had inhibitory rates over 60% on nitric oxide (NO) release. Subsequently, the anti-inflammatory activity of 3 – 5 was evaluated based on a zebrafish model, and the results showed that 3 had a significant inhibitory effect on inflammatory cells migration at 40 μmol/L, while 4 and 5 had a significant inhibitory effect at 20 μmol/L. Moreover, compounds 3 – 5 have the same conjugated double bond structure, which may be an important group for these compounds to exert anti-inflammatory activity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Marine Drugs 21 10 541 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Eutypella sp. D-1 diterpene anti-inflammatory zebrafish model Biology (General) QH301-705.5 |
spellingShingle |
Eutypella sp. D-1 diterpene anti-inflammatory zebrafish model Biology (General) QH301-705.5 Yaodong Ning Shi Zhang Te Zheng Yao Xu Song Li Jianpeng Zhang Binghua Jiao Yun Zhang Zengling Ma Xiaoling Lu Pimarane-Type Diterpenes with Anti-Inflammatory Activity from Arctic-Derived Fungus Eutypella sp. D-1 |
topic_facet |
Eutypella sp. D-1 diterpene anti-inflammatory zebrafish model Biology (General) QH301-705.5 |
description |
The Arctic-derived fungus Eutypella sp. D-1 can produce numerous secondary metabolites, and some compounds exhibit excellent biological activity. Seven pimarane-type diterpenes, including three new compounds eutypellenone F ( 1 ), libertellenone Y ( 2 ), and libertellenone Z ( 3 ), and four known compounds ( 4 – 7 ), were isolated from fermentation broth of Eutypella sp. D-1 by the OSMAC strategy of adding ethanol as a promoter in the culture medium. Compound 2 has a rare tetrahydrofuran-fused pimarane diterpene skeleton. The anti-inflammatory activity of all compounds was evaluated. Compounds 3 – 6 showed a significant inhibitory effect on cell NO release at 10 μmol/L by in vitro experiments, of which 3 – 5 had inhibitory rates over 60% on nitric oxide (NO) release. Subsequently, the anti-inflammatory activity of 3 – 5 was evaluated based on a zebrafish model, and the results showed that 3 had a significant inhibitory effect on inflammatory cells migration at 40 μmol/L, while 4 and 5 had a significant inhibitory effect at 20 μmol/L. Moreover, compounds 3 – 5 have the same conjugated double bond structure, which may be an important group for these compounds to exert anti-inflammatory activity. |
format |
Article in Journal/Newspaper |
author |
Yaodong Ning Shi Zhang Te Zheng Yao Xu Song Li Jianpeng Zhang Binghua Jiao Yun Zhang Zengling Ma Xiaoling Lu |
author_facet |
Yaodong Ning Shi Zhang Te Zheng Yao Xu Song Li Jianpeng Zhang Binghua Jiao Yun Zhang Zengling Ma Xiaoling Lu |
author_sort |
Yaodong Ning |
title |
Pimarane-Type Diterpenes with Anti-Inflammatory Activity from Arctic-Derived Fungus Eutypella sp. D-1 |
title_short |
Pimarane-Type Diterpenes with Anti-Inflammatory Activity from Arctic-Derived Fungus Eutypella sp. D-1 |
title_full |
Pimarane-Type Diterpenes with Anti-Inflammatory Activity from Arctic-Derived Fungus Eutypella sp. D-1 |
title_fullStr |
Pimarane-Type Diterpenes with Anti-Inflammatory Activity from Arctic-Derived Fungus Eutypella sp. D-1 |
title_full_unstemmed |
Pimarane-Type Diterpenes with Anti-Inflammatory Activity from Arctic-Derived Fungus Eutypella sp. D-1 |
title_sort |
pimarane-type diterpenes with anti-inflammatory activity from arctic-derived fungus eutypella sp. d-1 |
publisher |
MDPI AG |
publishDate |
2023 |
url |
https://doi.org/10.3390/md21100541 https://doaj.org/article/2287c2f0bf9b4dd39ace93caa3e31d4f |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Marine Drugs, Vol 21, Iss 541, p 541 (2023) |
op_relation |
https://www.mdpi.com/1660-3397/21/10/541 https://doaj.org/toc/1660-3397 doi:10.3390/md21100541 1660-3397 https://doaj.org/article/2287c2f0bf9b4dd39ace93caa3e31d4f |
op_doi |
https://doi.org/10.3390/md21100541 |
container_title |
Marine Drugs |
container_volume |
21 |
container_issue |
10 |
container_start_page |
541 |
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1782330968621711360 |