Systematic review and meta-analysis: rapid diagnostic tests versus placental histology, microscopy and PCR for malaria in pregnant women
Abstract Background During pregnancy, malaria infection with Plasmodium falciparum or Plasmodium vivax is related to adverse maternal health and poor birth outcomes. Diagnosis of malaria, during pregnancy, is complicated by the absence or low parasite densities in peripheral blood. Diagnostic method...
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ftdoajarticles:oai:doaj.org/article:22514f99fdb54fa3a04b9bfc3ac62962 2023-05-15T15:17:26+02:00 Systematic review and meta-analysis: rapid diagnostic tests versus placental histology, microscopy and PCR for malaria in pregnant women Kattenberg Johanna H Ochodo Eleanor A Boer Kimberly R Schallig Henk DFH Mens Petra F Leeflang Mariska MG 2011-10-01T00:00:00Z https://doi.org/10.1186/1475-2875-10-321 https://doaj.org/article/22514f99fdb54fa3a04b9bfc3ac62962 EN eng BMC http://www.malariajournal.com/content/10/1/321 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-321 1475-2875 https://doaj.org/article/22514f99fdb54fa3a04b9bfc3ac62962 Malaria Journal, Vol 10, Iss 1, p 321 (2011) Malaria pregnancy malaria in pregnancy (MiP) rapid diagnostic tests (RDTs) PCR microscopy histology diagnostic test accuracy systematic review meta-analysis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1186/1475-2875-10-321 2022-12-31T00:46:54Z Abstract Background During pregnancy, malaria infection with Plasmodium falciparum or Plasmodium vivax is related to adverse maternal health and poor birth outcomes. Diagnosis of malaria, during pregnancy, is complicated by the absence or low parasite densities in peripheral blood. Diagnostic methods, other than microscopy, are needed for detection of placental malaria. Therefore, the diagnostic accuracy of rapid diagnostic tests (RDTs), detecting antigen, and molecular techniques (PCR), detecting DNA, for the diagnosis of Plasmodium infections in pregnancy was systematically reviewed. Methods MEDLINE, EMBASE and Web of Science were searched for studies assessing the diagnostic accuracy of RDTs, PCR, microscopy of peripheral and placental blood and placental histology for the detection of malaria infection (all species) in pregnant women. Results The results of 49 studies were analysed in metandi (Stata), of which the majority described P. falciparum infections. Although both placental and peripheral blood microscopy cannot reliably replace histology as a reference standard for placental P. falciparum infection, many studies compared RDTs and PCR to these tests. The proportion of microscopy positives in placental blood (sensitivity) detected by peripheral blood microscopy, RDTs and PCR are respectively 72% [95% CI 62-80], 81% [95% CI 55-93] and 94% [95% CI 86-98]. The proportion of placental blood microscopy negative women that were negative in peripheral blood microscopy, RDTs and PCR (specificity) are 98% [95% CI 95-99], 94% [95% CI 76-99] and 77% [95% CI 71-82]. Based on the current data, it was not possible to determine if the false positives in RDTs and PCR are caused by sequestered parasites in the placenta that are not detected by placental microscopy. Conclusion The findings suggest that RDTs and PCR may have good performance characteristics to serve as alternatives for the diagnosis of malaria in pregnancy, besides any other limitations and practical considerations concerning the use of these tests. ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 10 1 |
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topic |
Malaria pregnancy malaria in pregnancy (MiP) rapid diagnostic tests (RDTs) PCR microscopy histology diagnostic test accuracy systematic review meta-analysis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria pregnancy malaria in pregnancy (MiP) rapid diagnostic tests (RDTs) PCR microscopy histology diagnostic test accuracy systematic review meta-analysis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Kattenberg Johanna H Ochodo Eleanor A Boer Kimberly R Schallig Henk DFH Mens Petra F Leeflang Mariska MG Systematic review and meta-analysis: rapid diagnostic tests versus placental histology, microscopy and PCR for malaria in pregnant women |
topic_facet |
Malaria pregnancy malaria in pregnancy (MiP) rapid diagnostic tests (RDTs) PCR microscopy histology diagnostic test accuracy systematic review meta-analysis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background During pregnancy, malaria infection with Plasmodium falciparum or Plasmodium vivax is related to adverse maternal health and poor birth outcomes. Diagnosis of malaria, during pregnancy, is complicated by the absence or low parasite densities in peripheral blood. Diagnostic methods, other than microscopy, are needed for detection of placental malaria. Therefore, the diagnostic accuracy of rapid diagnostic tests (RDTs), detecting antigen, and molecular techniques (PCR), detecting DNA, for the diagnosis of Plasmodium infections in pregnancy was systematically reviewed. Methods MEDLINE, EMBASE and Web of Science were searched for studies assessing the diagnostic accuracy of RDTs, PCR, microscopy of peripheral and placental blood and placental histology for the detection of malaria infection (all species) in pregnant women. Results The results of 49 studies were analysed in metandi (Stata), of which the majority described P. falciparum infections. Although both placental and peripheral blood microscopy cannot reliably replace histology as a reference standard for placental P. falciparum infection, many studies compared RDTs and PCR to these tests. The proportion of microscopy positives in placental blood (sensitivity) detected by peripheral blood microscopy, RDTs and PCR are respectively 72% [95% CI 62-80], 81% [95% CI 55-93] and 94% [95% CI 86-98]. The proportion of placental blood microscopy negative women that were negative in peripheral blood microscopy, RDTs and PCR (specificity) are 98% [95% CI 95-99], 94% [95% CI 76-99] and 77% [95% CI 71-82]. Based on the current data, it was not possible to determine if the false positives in RDTs and PCR are caused by sequestered parasites in the placenta that are not detected by placental microscopy. Conclusion The findings suggest that RDTs and PCR may have good performance characteristics to serve as alternatives for the diagnosis of malaria in pregnancy, besides any other limitations and practical considerations concerning the use of these tests. ... |
format |
Article in Journal/Newspaper |
author |
Kattenberg Johanna H Ochodo Eleanor A Boer Kimberly R Schallig Henk DFH Mens Petra F Leeflang Mariska MG |
author_facet |
Kattenberg Johanna H Ochodo Eleanor A Boer Kimberly R Schallig Henk DFH Mens Petra F Leeflang Mariska MG |
author_sort |
Kattenberg Johanna H |
title |
Systematic review and meta-analysis: rapid diagnostic tests versus placental histology, microscopy and PCR for malaria in pregnant women |
title_short |
Systematic review and meta-analysis: rapid diagnostic tests versus placental histology, microscopy and PCR for malaria in pregnant women |
title_full |
Systematic review and meta-analysis: rapid diagnostic tests versus placental histology, microscopy and PCR for malaria in pregnant women |
title_fullStr |
Systematic review and meta-analysis: rapid diagnostic tests versus placental histology, microscopy and PCR for malaria in pregnant women |
title_full_unstemmed |
Systematic review and meta-analysis: rapid diagnostic tests versus placental histology, microscopy and PCR for malaria in pregnant women |
title_sort |
systematic review and meta-analysis: rapid diagnostic tests versus placental histology, microscopy and pcr for malaria in pregnant women |
publisher |
BMC |
publishDate |
2011 |
url |
https://doi.org/10.1186/1475-2875-10-321 https://doaj.org/article/22514f99fdb54fa3a04b9bfc3ac62962 |
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Arctic |
geographic_facet |
Arctic |
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Arctic |
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Arctic |
op_source |
Malaria Journal, Vol 10, Iss 1, p 321 (2011) |
op_relation |
http://www.malariajournal.com/content/10/1/321 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-321 1475-2875 https://doaj.org/article/22514f99fdb54fa3a04b9bfc3ac62962 |
op_doi |
https://doi.org/10.1186/1475-2875-10-321 |
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Malaria Journal |
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10 |
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1766347675737784320 |