Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis
The aim. The objective of the research was to study the pharmacological activity of dry extract of Sakhalin willow shoots – DEWS against the background of experimental thrombophlebitis. Materials and methods. Dry extract of Sakhalin willow shoots (DEWS) was the object matter of the present research...
Published in: | ScienceRise: Pharmaceutical Science |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
PC Technology Center
2023
|
Subjects: | |
Online Access: | https://doi.org/10.15587/2519-4852.2023.286723 https://doaj.org/article/2235788b13974c379f31fbe6581b2159 |
id |
ftdoajarticles:oai:doaj.org/article:2235788b13974c379f31fbe6581b2159 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:2235788b13974c379f31fbe6581b2159 2023-10-09T21:55:41+02:00 Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis Liudmyla Maloshtan Kateryna Artemova Natalia Borodina Oleksandr Kukhtenko 2023-08-01T00:00:00Z https://doi.org/10.15587/2519-4852.2023.286723 https://doaj.org/article/2235788b13974c379f31fbe6581b2159 EN eng PC Technology Center https://journals.uran.ua/sr_pharm/article/view/286723 https://doaj.org/toc/2519-4844 https://doaj.org/toc/2519-4852 2519-4844 2519-4852 doi:10.15587/2519-4852.2023.286723 https://doaj.org/article/2235788b13974c379f31fbe6581b2159 ScienceRise: Pharmaceutical Science, Iss 4(44), Pp 97-103 (2023) dry extract of sakhalin willow shoots experimental thrombophlebitis inflammatory process pharmacological activity rabbits Pharmacy and materia medica RS1-441 article 2023 ftdoajarticles https://doi.org/10.15587/2519-4852.2023.286723 2023-09-17T00:36:18Z The aim. The objective of the research was to study the pharmacological activity of dry extract of Sakhalin willow shoots – DEWS against the background of experimental thrombophlebitis. Materials and methods. Dry extract of Sakhalin willow shoots (DEWS) was the object matter of the present research and served as a therapeutic and prophylactic agent. In the experiment conducted, rabbits weighing 2.0 – 2.5 kg were used. The animals were divided into three groups. Group 1 was a control group; group 2 were animals that had been intragastrically injected with DEWS at a dose of 30 mg/kg prior to modelling thrombophlebitis; group 3 similarly received Eskuvit 20 mg/kg as a reference drug – pills (JSC Halychpharm, Ukraine). The dose for animals was recalculated, taking into account body weight according to the Rybolovlev method. Experimental thrombophlebitis was caused by injecting an intravenous solution of 2 % lugol at a dose of 0.1 ml into the marginal vein of the ear. Statistical data processing was carried out using the Statistica for Windows 11.0 program based on variance analysis for repeated measurement data using the Mann-Whitney criteria at a probability level of p<0.05. Results. Against the background of the development of experimental thrombophlebitis in rabbits, the development of thrombosis of the ear vein and the inflammatory process of adjacent tissues were observed. The inflammatory process was accompanied by pronounced hyperemia and oedema. Prophylactic administration of DEWS for 6 days contributed to a decrease in the inflammatory process already on the 5th day of observation. The area of the injured area was 20 % smaller than in the control pathology group. The therapeutic and prophylactic effect of herbal medicine can be explained by the content of flavonoids and salicylates in its composition. Eskuvit showed a less pronounced thrombolytic effect in terms of its influence on thrombosis and thrombolysis. Conclusions. The administration of DEWS in the therapeutic and prophylactic regimen at a dose ... Article in Journal/Newspaper Sakhalin Directory of Open Access Journals: DOAJ Articles ScienceRise: Pharmaceutical Science 4(44) 97 103 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
dry extract of sakhalin willow shoots experimental thrombophlebitis inflammatory process pharmacological activity rabbits Pharmacy and materia medica RS1-441 |
spellingShingle |
dry extract of sakhalin willow shoots experimental thrombophlebitis inflammatory process pharmacological activity rabbits Pharmacy and materia medica RS1-441 Liudmyla Maloshtan Kateryna Artemova Natalia Borodina Oleksandr Kukhtenko Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis |
topic_facet |
dry extract of sakhalin willow shoots experimental thrombophlebitis inflammatory process pharmacological activity rabbits Pharmacy and materia medica RS1-441 |
description |
The aim. The objective of the research was to study the pharmacological activity of dry extract of Sakhalin willow shoots – DEWS against the background of experimental thrombophlebitis. Materials and methods. Dry extract of Sakhalin willow shoots (DEWS) was the object matter of the present research and served as a therapeutic and prophylactic agent. In the experiment conducted, rabbits weighing 2.0 – 2.5 kg were used. The animals were divided into three groups. Group 1 was a control group; group 2 were animals that had been intragastrically injected with DEWS at a dose of 30 mg/kg prior to modelling thrombophlebitis; group 3 similarly received Eskuvit 20 mg/kg as a reference drug – pills (JSC Halychpharm, Ukraine). The dose for animals was recalculated, taking into account body weight according to the Rybolovlev method. Experimental thrombophlebitis was caused by injecting an intravenous solution of 2 % lugol at a dose of 0.1 ml into the marginal vein of the ear. Statistical data processing was carried out using the Statistica for Windows 11.0 program based on variance analysis for repeated measurement data using the Mann-Whitney criteria at a probability level of p<0.05. Results. Against the background of the development of experimental thrombophlebitis in rabbits, the development of thrombosis of the ear vein and the inflammatory process of adjacent tissues were observed. The inflammatory process was accompanied by pronounced hyperemia and oedema. Prophylactic administration of DEWS for 6 days contributed to a decrease in the inflammatory process already on the 5th day of observation. The area of the injured area was 20 % smaller than in the control pathology group. The therapeutic and prophylactic effect of herbal medicine can be explained by the content of flavonoids and salicylates in its composition. Eskuvit showed a less pronounced thrombolytic effect in terms of its influence on thrombosis and thrombolysis. Conclusions. The administration of DEWS in the therapeutic and prophylactic regimen at a dose ... |
format |
Article in Journal/Newspaper |
author |
Liudmyla Maloshtan Kateryna Artemova Natalia Borodina Oleksandr Kukhtenko |
author_facet |
Liudmyla Maloshtan Kateryna Artemova Natalia Borodina Oleksandr Kukhtenko |
author_sort |
Liudmyla Maloshtan |
title |
Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis |
title_short |
Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis |
title_full |
Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis |
title_fullStr |
Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis |
title_full_unstemmed |
Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis |
title_sort |
study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis |
publisher |
PC Technology Center |
publishDate |
2023 |
url |
https://doi.org/10.15587/2519-4852.2023.286723 https://doaj.org/article/2235788b13974c379f31fbe6581b2159 |
genre |
Sakhalin |
genre_facet |
Sakhalin |
op_source |
ScienceRise: Pharmaceutical Science, Iss 4(44), Pp 97-103 (2023) |
op_relation |
https://journals.uran.ua/sr_pharm/article/view/286723 https://doaj.org/toc/2519-4844 https://doaj.org/toc/2519-4852 2519-4844 2519-4852 doi:10.15587/2519-4852.2023.286723 https://doaj.org/article/2235788b13974c379f31fbe6581b2159 |
op_doi |
https://doi.org/10.15587/2519-4852.2023.286723 |
container_title |
ScienceRise: Pharmaceutical Science |
container_issue |
4(44) |
container_start_page |
97 |
op_container_end_page |
103 |
_version_ |
1779319673317228544 |