Histiocytic necrotizing lymphadenitis (Kikuchi lymphadenitis) in an HIV-positive patient Linfadenite necrosante histiocítica (linfadenite de Kikuchi) em um paciente HIV-positivo
Histiocytic necrotizing lymphadenitis, or Kikuchi's lymphadenitis (KL), is an unusual form of lymphadenitis, generally with self-limited clinical course. KL has been reported in rare patients infected with the human immunodeficiency virus (HIV). Pathogenesis of the lesion is probably related to...
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Universidade de São Paulo (USP)
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ftdoajarticles:oai:doaj.org/article:2218fa4ade4c4604aa7673824c018497 2024-09-09T19:27:58+00:00 Histiocytic necrotizing lymphadenitis (Kikuchi lymphadenitis) in an HIV-positive patient Linfadenite necrosante histiocítica (linfadenite de Kikuchi) em um paciente HIV-positivo José VASSALLO João Carlos COELHO FILHO Vânia Gondin Pires do AMARAL 2002-10-01T00:00:00Z https://doi.org/10.1590/S0036-46652002000500006 https://doaj.org/article/2218fa4ade4c4604aa7673824c018497 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652002000500006 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652002000500006 0036-4665 1678-9946 https://doaj.org/article/2218fa4ade4c4604aa7673824c018497 Revista do Instituto de Medicina Tropical de São Paulo, Vol 44, Iss 5, Pp 256-268 (2002) Histiocytic necrotizing lymphadenitis Kikuchi lymphadenitis AIDS HIV Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2002 ftdoajarticles https://doi.org/10.1590/S0036-46652002000500006 2024-08-05T17:49:30Z Histiocytic necrotizing lymphadenitis, or Kikuchi's lymphadenitis (KL), is an unusual form of lymphadenitis, generally with self-limited clinical course. KL has been reported in rare patients infected with the human immunodeficiency virus (HIV). Pathogenesis of the lesion is probably related to an impaired immune function. The purpose of the present article is to report on one case in which KL was diagnosed in an HIV-infected patient. Histomorphology and immunophenotype were similar to previous reports, but a focus of activated CD30+ macrophages was seen, what might be due to the immunological status of the patient. EBV was not detected on the sections using the in situ hybridization technique. Although rare, the occurrence of KL in HIV-infected subjects must be emphasized, because of the potential misdiagnosis of malignancy, especially in the presence of CD30+ cells. A linfadenite necrosante histiocítica, ou linfadenite de Kikuchi (LK), é uma forma rara de linfadenite, geralmente de curso clínico auto-limitado. Raros casos de LK associados à infecção pelo vírus da imunodeficiência humana (HIV) foram relatados, sendo sua patogênese atribuída à disfunção imunológica destes pacientes. O objetivo do presente artigo é relatar um caso de associação de LK em um paciente HIV-positivo. A histomorfologia e a imunofenotipagem foram semelhantes aos casos anteriormente descritos na literatura, mas focos de macrófagos ativados positivos para o CD30 foram vistos, o que pode ser devido ao estado imune do paciente. A pesquisa de EBV por hibridização in situ foi negativa no tecido. Embora rara, a ocorrência de LK em pacientes HIV-positivos deve ser lembrada, por causa do potencial erro diagnóstico com linfoma maligno, especialmente na presença de células CD30+. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 44 5 256 268 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Histiocytic necrotizing lymphadenitis Kikuchi lymphadenitis AIDS HIV Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Histiocytic necrotizing lymphadenitis Kikuchi lymphadenitis AIDS HIV Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 José VASSALLO João Carlos COELHO FILHO Vânia Gondin Pires do AMARAL Histiocytic necrotizing lymphadenitis (Kikuchi lymphadenitis) in an HIV-positive patient Linfadenite necrosante histiocítica (linfadenite de Kikuchi) em um paciente HIV-positivo |
topic_facet |
Histiocytic necrotizing lymphadenitis Kikuchi lymphadenitis AIDS HIV Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Histiocytic necrotizing lymphadenitis, or Kikuchi's lymphadenitis (KL), is an unusual form of lymphadenitis, generally with self-limited clinical course. KL has been reported in rare patients infected with the human immunodeficiency virus (HIV). Pathogenesis of the lesion is probably related to an impaired immune function. The purpose of the present article is to report on one case in which KL was diagnosed in an HIV-infected patient. Histomorphology and immunophenotype were similar to previous reports, but a focus of activated CD30+ macrophages was seen, what might be due to the immunological status of the patient. EBV was not detected on the sections using the in situ hybridization technique. Although rare, the occurrence of KL in HIV-infected subjects must be emphasized, because of the potential misdiagnosis of malignancy, especially in the presence of CD30+ cells. A linfadenite necrosante histiocítica, ou linfadenite de Kikuchi (LK), é uma forma rara de linfadenite, geralmente de curso clínico auto-limitado. Raros casos de LK associados à infecção pelo vírus da imunodeficiência humana (HIV) foram relatados, sendo sua patogênese atribuída à disfunção imunológica destes pacientes. O objetivo do presente artigo é relatar um caso de associação de LK em um paciente HIV-positivo. A histomorfologia e a imunofenotipagem foram semelhantes aos casos anteriormente descritos na literatura, mas focos de macrófagos ativados positivos para o CD30 foram vistos, o que pode ser devido ao estado imune do paciente. A pesquisa de EBV por hibridização in situ foi negativa no tecido. Embora rara, a ocorrência de LK em pacientes HIV-positivos deve ser lembrada, por causa do potencial erro diagnóstico com linfoma maligno, especialmente na presença de células CD30+. |
format |
Article in Journal/Newspaper |
author |
José VASSALLO João Carlos COELHO FILHO Vânia Gondin Pires do AMARAL |
author_facet |
José VASSALLO João Carlos COELHO FILHO Vânia Gondin Pires do AMARAL |
author_sort |
José VASSALLO |
title |
Histiocytic necrotizing lymphadenitis (Kikuchi lymphadenitis) in an HIV-positive patient Linfadenite necrosante histiocítica (linfadenite de Kikuchi) em um paciente HIV-positivo |
title_short |
Histiocytic necrotizing lymphadenitis (Kikuchi lymphadenitis) in an HIV-positive patient Linfadenite necrosante histiocítica (linfadenite de Kikuchi) em um paciente HIV-positivo |
title_full |
Histiocytic necrotizing lymphadenitis (Kikuchi lymphadenitis) in an HIV-positive patient Linfadenite necrosante histiocítica (linfadenite de Kikuchi) em um paciente HIV-positivo |
title_fullStr |
Histiocytic necrotizing lymphadenitis (Kikuchi lymphadenitis) in an HIV-positive patient Linfadenite necrosante histiocítica (linfadenite de Kikuchi) em um paciente HIV-positivo |
title_full_unstemmed |
Histiocytic necrotizing lymphadenitis (Kikuchi lymphadenitis) in an HIV-positive patient Linfadenite necrosante histiocítica (linfadenite de Kikuchi) em um paciente HIV-positivo |
title_sort |
histiocytic necrotizing lymphadenitis (kikuchi lymphadenitis) in an hiv-positive patient linfadenite necrosante histiocítica (linfadenite de kikuchi) em um paciente hiv-positivo |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2002 |
url |
https://doi.org/10.1590/S0036-46652002000500006 https://doaj.org/article/2218fa4ade4c4604aa7673824c018497 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 44, Iss 5, Pp 256-268 (2002) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652002000500006 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652002000500006 0036-4665 1678-9946 https://doaj.org/article/2218fa4ade4c4604aa7673824c018497 |
op_doi |
https://doi.org/10.1590/S0036-46652002000500006 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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44 |
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