The dynamic of asymptomatic Plasmodium falciparum infections following mass drug administrations with dihydroarteminisin–piperaquine plus a single low dose of primaquine in Savannakhet Province, Laos
Abstract Background The increase in multidrug resistant Plasmodium falciparum infections threatens the malaria elimination goals in countries within the Greater Mekong Sub-region. A multi-pronged approach assuring access to basic malaria control measures, including insecticide-treated bed nets and e...
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ftdoajarticles:oai:doaj.org/article:220b26ab471b457a924d30a8729fb29b 2023-05-15T15:17:07+02:00 The dynamic of asymptomatic Plasmodium falciparum infections following mass drug administrations with dihydroarteminisin–piperaquine plus a single low dose of primaquine in Savannakhet Province, Laos Tiengkham Pongvongsa Koukeo Phommasone Bipin Adhikari Gisela Henriques Kesinee Chotivanich Borimas Hanboonkunupakarn Mavuto Mukaka Pimnara Peerawaranun Lorenz von Seidlein Nicholas P. J. Day Nicholas J. White Arjen M. Dondorp Mallika Imwong Paul N. Newton Pratap Singhasivanon Mayfong Mayxay Sasithon Pukrittayakamee 2018-11-01T00:00:00Z https://doi.org/10.1186/s12936-018-2541-9 https://doaj.org/article/220b26ab471b457a924d30a8729fb29b EN eng BMC http://link.springer.com/article/10.1186/s12936-018-2541-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2541-9 1475-2875 https://doaj.org/article/220b26ab471b457a924d30a8729fb29b Malaria Journal, Vol 17, Iss 1, Pp 1-13 (2018) Asymptomatic parasitaemia P. falciparum Elimination MDA Savannakhet Laos Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12936-018-2541-9 2022-12-31T07:03:44Z Abstract Background The increase in multidrug resistant Plasmodium falciparum infections threatens the malaria elimination goals in countries within the Greater Mekong Sub-region. A multi-pronged approach assuring access to basic malaria control measures, including insecticide-treated bed nets and early diagnosis and treatment was followed by mass drug administrations (MDA) in southern Savannakhet Province, Laos. The main objective of this study was to evaluate the effectiveness and safety of mass drug administrations as well as their effects on the dynamic of asymptomatic P. falciparum infections in 4 malaria endemic villages. Methods Two villages were randomized to early MDA consisting of 3 rounds of a 3-day course of dihydroartemisinin–piperaquine with a single low dose of primaquine. In the other 2 villages MDA was deferred by 1 year. A total of 1036 residents were enrolled in early MDA villages and 883 in control villages (deferred-MDA). Tri-monthly parasitaemia surveys using uPCR were conducted for a year in the 4 villages. Results Eighty-four percent (872/1036) of the residents participated in the MDAs, of whom 90% (781/872) completed 3 rounds of MDA (9 doses). In intervention villages, the prevalence of asymptomatic P. falciparum infections decreased by 85% after MDA from 4.8% (95% CI 3.4–6.4) at baseline (month 0 or M0) to 0.7% (95% CI 0.3–1.6) at month 12. In control villages there was a decrease of 33% in P. falciparum prevalence between M0: 17.5% (95% CI 15.9–20.3) and M12: 11.6% (95% CI 9.3–14.2). In bivariate and multivariate analyses P. falciparum infections were significantly reduced with early MDA (adjusted incidence rate ratios (AIRR): 0.08, CI 0.01–0.091) and completion of 3 MDA rounds (AIRR: 0.06; CI 0.01–0.66). A quarter of participants (226/872) reported adverse events of which 99% were mild. Conclusion The study found a significant reduction in P. falciparum prevalence and incidence following MDA. MDA was safe, well tolerated, feasible, and achieved high population coverage and adherence. ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 17 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Asymptomatic parasitaemia P. falciparum Elimination MDA Savannakhet Laos Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Asymptomatic parasitaemia P. falciparum Elimination MDA Savannakhet Laos Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Tiengkham Pongvongsa Koukeo Phommasone Bipin Adhikari Gisela Henriques Kesinee Chotivanich Borimas Hanboonkunupakarn Mavuto Mukaka Pimnara Peerawaranun Lorenz von Seidlein Nicholas P. J. Day Nicholas J. White Arjen M. Dondorp Mallika Imwong Paul N. Newton Pratap Singhasivanon Mayfong Mayxay Sasithon Pukrittayakamee The dynamic of asymptomatic Plasmodium falciparum infections following mass drug administrations with dihydroarteminisin–piperaquine plus a single low dose of primaquine in Savannakhet Province, Laos |
topic_facet |
Asymptomatic parasitaemia P. falciparum Elimination MDA Savannakhet Laos Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The increase in multidrug resistant Plasmodium falciparum infections threatens the malaria elimination goals in countries within the Greater Mekong Sub-region. A multi-pronged approach assuring access to basic malaria control measures, including insecticide-treated bed nets and early diagnosis and treatment was followed by mass drug administrations (MDA) in southern Savannakhet Province, Laos. The main objective of this study was to evaluate the effectiveness and safety of mass drug administrations as well as their effects on the dynamic of asymptomatic P. falciparum infections in 4 malaria endemic villages. Methods Two villages were randomized to early MDA consisting of 3 rounds of a 3-day course of dihydroartemisinin–piperaquine with a single low dose of primaquine. In the other 2 villages MDA was deferred by 1 year. A total of 1036 residents were enrolled in early MDA villages and 883 in control villages (deferred-MDA). Tri-monthly parasitaemia surveys using uPCR were conducted for a year in the 4 villages. Results Eighty-four percent (872/1036) of the residents participated in the MDAs, of whom 90% (781/872) completed 3 rounds of MDA (9 doses). In intervention villages, the prevalence of asymptomatic P. falciparum infections decreased by 85% after MDA from 4.8% (95% CI 3.4–6.4) at baseline (month 0 or M0) to 0.7% (95% CI 0.3–1.6) at month 12. In control villages there was a decrease of 33% in P. falciparum prevalence between M0: 17.5% (95% CI 15.9–20.3) and M12: 11.6% (95% CI 9.3–14.2). In bivariate and multivariate analyses P. falciparum infections were significantly reduced with early MDA (adjusted incidence rate ratios (AIRR): 0.08, CI 0.01–0.091) and completion of 3 MDA rounds (AIRR: 0.06; CI 0.01–0.66). A quarter of participants (226/872) reported adverse events of which 99% were mild. Conclusion The study found a significant reduction in P. falciparum prevalence and incidence following MDA. MDA was safe, well tolerated, feasible, and achieved high population coverage and adherence. ... |
format |
Article in Journal/Newspaper |
author |
Tiengkham Pongvongsa Koukeo Phommasone Bipin Adhikari Gisela Henriques Kesinee Chotivanich Borimas Hanboonkunupakarn Mavuto Mukaka Pimnara Peerawaranun Lorenz von Seidlein Nicholas P. J. Day Nicholas J. White Arjen M. Dondorp Mallika Imwong Paul N. Newton Pratap Singhasivanon Mayfong Mayxay Sasithon Pukrittayakamee |
author_facet |
Tiengkham Pongvongsa Koukeo Phommasone Bipin Adhikari Gisela Henriques Kesinee Chotivanich Borimas Hanboonkunupakarn Mavuto Mukaka Pimnara Peerawaranun Lorenz von Seidlein Nicholas P. J. Day Nicholas J. White Arjen M. Dondorp Mallika Imwong Paul N. Newton Pratap Singhasivanon Mayfong Mayxay Sasithon Pukrittayakamee |
author_sort |
Tiengkham Pongvongsa |
title |
The dynamic of asymptomatic Plasmodium falciparum infections following mass drug administrations with dihydroarteminisin–piperaquine plus a single low dose of primaquine in Savannakhet Province, Laos |
title_short |
The dynamic of asymptomatic Plasmodium falciparum infections following mass drug administrations with dihydroarteminisin–piperaquine plus a single low dose of primaquine in Savannakhet Province, Laos |
title_full |
The dynamic of asymptomatic Plasmodium falciparum infections following mass drug administrations with dihydroarteminisin–piperaquine plus a single low dose of primaquine in Savannakhet Province, Laos |
title_fullStr |
The dynamic of asymptomatic Plasmodium falciparum infections following mass drug administrations with dihydroarteminisin–piperaquine plus a single low dose of primaquine in Savannakhet Province, Laos |
title_full_unstemmed |
The dynamic of asymptomatic Plasmodium falciparum infections following mass drug administrations with dihydroarteminisin–piperaquine plus a single low dose of primaquine in Savannakhet Province, Laos |
title_sort |
dynamic of asymptomatic plasmodium falciparum infections following mass drug administrations with dihydroarteminisin–piperaquine plus a single low dose of primaquine in savannakhet province, laos |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s12936-018-2541-9 https://doaj.org/article/220b26ab471b457a924d30a8729fb29b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 17, Iss 1, Pp 1-13 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s12936-018-2541-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2541-9 1475-2875 https://doaj.org/article/220b26ab471b457a924d30a8729fb29b |
op_doi |
https://doi.org/10.1186/s12936-018-2541-9 |
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Malaria Journal |
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17 |
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1 |
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1766347389449273344 |