Plasma glutathione and oxidized glutathione level, glutathione/oxidized glutathione ratio, and albumin concentration in complicated and uncomplicated falciparum malaria
Objective: To compare the level of glutathione (GSH) and oxidized glutathione (GSSG), the ratio of GSH/GSSG and the concentration of albumin in plasma of patients with complicated and un-complicated falciparum malaria. Methods: This research was a cross sectional study using comparison analysis with...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Wolters Kluwer Medknow Publications
2016
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Online Access: | https://doi.org/10.1016/j.apjtb.2016.06.003 https://doaj.org/article/21f80662b8cd4fe6b4431d8f849966e1 |
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ftdoajarticles:oai:doaj.org/article:21f80662b8cd4fe6b4431d8f849966e1 2023-05-15T15:12:35+02:00 Plasma glutathione and oxidized glutathione level, glutathione/oxidized glutathione ratio, and albumin concentration in complicated and uncomplicated falciparum malaria Loeki Enggar Fitri Agustin Iskandar Teguh Wahju Sardjono Ummu Ditya Erliana Widya Rahmawati Didi Candradikusuma Utama Budi Saputra Eko Suhartono Bambang Setiawan Erma Sulistyaningsih 2016-08-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2016.06.003 https://doaj.org/article/21f80662b8cd4fe6b4431d8f849966e1 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115308911 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.06.003 https://doaj.org/article/21f80662b8cd4fe6b4431d8f849966e1 Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 8, Pp 646-650 (2016) Albumin Complicated malaria Glutathione Oxidized glutathione Glutathione/oxidized glutathione ratio Uncomplicated malaria Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2016 ftdoajarticles https://doi.org/10.1016/j.apjtb.2016.06.003 2022-12-31T11:03:49Z Objective: To compare the level of glutathione (GSH) and oxidized glutathione (GSSG), the ratio of GSH/GSSG and the concentration of albumin in plasma of patients with complicated and un-complicated falciparum malaria. Methods: This research was a cross sectional study using comparison analysis with the plasma GSH and GSSG, the ratio of plasma GSH/GSSG and the concentration of plasma albumin as variables. The complicated malaria patients were obtained from Dr. Saiful Anwar Hospital Malang, whereas uncomplicated malaria patients were obtained from the Regency of Pleihari South Kalimantan. Plasma GSH and GSSG levels were determined by the spectrophotometer at the wave length of 412 nm, whereas the concentration of albumin was determined by bromocresol green method in the pH of 4.1. Results: There were no significant differences between the level of plasma GSH and GSSG in complicated and uncomplicated malaria patients, as well as the ratio of plasma GSH/GSSG in the two groups (P = 0.373; P = 0.538; and P = 0.615, respectively, independent t-test). In contrast, the plasma albumin concentration in complicated malaria patients were significantly higher than uncomplicated malaria patients (P = 0.000, Mann Whitney U test). Conclusions: It can be concluded that the average of plasma GSH and GSSG level, also plasma GSH/GSSG ratio in complicated malaria are not different from uncomplicated malaria. Although plasma concentration of albumin in both groups is below the normal range, there is an increase in complicated malaria that might be as compensation of oxidative stress. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 6 8 646 650 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Albumin Complicated malaria Glutathione Oxidized glutathione Glutathione/oxidized glutathione ratio Uncomplicated malaria Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Albumin Complicated malaria Glutathione Oxidized glutathione Glutathione/oxidized glutathione ratio Uncomplicated malaria Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Loeki Enggar Fitri Agustin Iskandar Teguh Wahju Sardjono Ummu Ditya Erliana Widya Rahmawati Didi Candradikusuma Utama Budi Saputra Eko Suhartono Bambang Setiawan Erma Sulistyaningsih Plasma glutathione and oxidized glutathione level, glutathione/oxidized glutathione ratio, and albumin concentration in complicated and uncomplicated falciparum malaria |
topic_facet |
Albumin Complicated malaria Glutathione Oxidized glutathione Glutathione/oxidized glutathione ratio Uncomplicated malaria Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To compare the level of glutathione (GSH) and oxidized glutathione (GSSG), the ratio of GSH/GSSG and the concentration of albumin in plasma of patients with complicated and un-complicated falciparum malaria. Methods: This research was a cross sectional study using comparison analysis with the plasma GSH and GSSG, the ratio of plasma GSH/GSSG and the concentration of plasma albumin as variables. The complicated malaria patients were obtained from Dr. Saiful Anwar Hospital Malang, whereas uncomplicated malaria patients were obtained from the Regency of Pleihari South Kalimantan. Plasma GSH and GSSG levels were determined by the spectrophotometer at the wave length of 412 nm, whereas the concentration of albumin was determined by bromocresol green method in the pH of 4.1. Results: There were no significant differences between the level of plasma GSH and GSSG in complicated and uncomplicated malaria patients, as well as the ratio of plasma GSH/GSSG in the two groups (P = 0.373; P = 0.538; and P = 0.615, respectively, independent t-test). In contrast, the plasma albumin concentration in complicated malaria patients were significantly higher than uncomplicated malaria patients (P = 0.000, Mann Whitney U test). Conclusions: It can be concluded that the average of plasma GSH and GSSG level, also plasma GSH/GSSG ratio in complicated malaria are not different from uncomplicated malaria. Although plasma concentration of albumin in both groups is below the normal range, there is an increase in complicated malaria that might be as compensation of oxidative stress. |
format |
Article in Journal/Newspaper |
author |
Loeki Enggar Fitri Agustin Iskandar Teguh Wahju Sardjono Ummu Ditya Erliana Widya Rahmawati Didi Candradikusuma Utama Budi Saputra Eko Suhartono Bambang Setiawan Erma Sulistyaningsih |
author_facet |
Loeki Enggar Fitri Agustin Iskandar Teguh Wahju Sardjono Ummu Ditya Erliana Widya Rahmawati Didi Candradikusuma Utama Budi Saputra Eko Suhartono Bambang Setiawan Erma Sulistyaningsih |
author_sort |
Loeki Enggar Fitri |
title |
Plasma glutathione and oxidized glutathione level, glutathione/oxidized glutathione ratio, and albumin concentration in complicated and uncomplicated falciparum malaria |
title_short |
Plasma glutathione and oxidized glutathione level, glutathione/oxidized glutathione ratio, and albumin concentration in complicated and uncomplicated falciparum malaria |
title_full |
Plasma glutathione and oxidized glutathione level, glutathione/oxidized glutathione ratio, and albumin concentration in complicated and uncomplicated falciparum malaria |
title_fullStr |
Plasma glutathione and oxidized glutathione level, glutathione/oxidized glutathione ratio, and albumin concentration in complicated and uncomplicated falciparum malaria |
title_full_unstemmed |
Plasma glutathione and oxidized glutathione level, glutathione/oxidized glutathione ratio, and albumin concentration in complicated and uncomplicated falciparum malaria |
title_sort |
plasma glutathione and oxidized glutathione level, glutathione/oxidized glutathione ratio, and albumin concentration in complicated and uncomplicated falciparum malaria |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2016 |
url |
https://doi.org/10.1016/j.apjtb.2016.06.003 https://doaj.org/article/21f80662b8cd4fe6b4431d8f849966e1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 8, Pp 646-650 (2016) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115308911 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.06.003 https://doaj.org/article/21f80662b8cd4fe6b4431d8f849966e1 |
op_doi |
https://doi.org/10.1016/j.apjtb.2016.06.003 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
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6 |
container_issue |
8 |
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646 |
op_container_end_page |
650 |
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1766343254374088704 |