Mitochondrial oxidative damage and apoptosis induced by high glucose through Rho kinase signal pathway in renal tubular epithelial cells

• Published in: Asian Pacific Journal of Tropical Medicine
• Main Authors: Wen-Ning Li, Hui Han, Zi-Yang Jing, Xiao-Hong Yang, Yin Zhang, Jia-Li Wei
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018
• Subjects: diabetic nephropathy; mitochondrial oxidative stress; rho kinase signal pathway; tubular epithelial cell; Arctic medicine. Tropical medicine; RC955-962; Arctic; Rho
• Online Access: https://doi.org/10.4103/1995-7645.234769; https://doaj.org/article/21f2e3c5f67c4a45a170569c3b71740a

Objective: To investigate the role of oxidative stress in human renal tubular epithelial cells (HK-2) induced by high glucose and the underlying signal pathway in vitro. Methods: MYPT1, pro-caspase-3, PGC-1α, and Drp1 protein expressions were measured by Western blot. MnSOD2, Drp1 and PGC-1α mRNA ex...