High Resolution Esophageal Manometry in Patients with Chagas Disease: A Cross-Sectional Evaluation.
INTRODUCTION:Gastrointestinal involvement affects 30-40% of the patients with chronic Chagas disease. Esophageal symptoms appear once the structural damage is established. Little is known about the usefulness of high resolution manometry to early identification of esophageal involvement. METHOD:We p...
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ftdoajarticles:oai:doaj.org/article:21d26fb53c8547329d873cde51165b63 2023-05-15T15:15:18+02:00 High Resolution Esophageal Manometry in Patients with Chagas Disease: A Cross-Sectional Evaluation. Adrián Sánchez-Montalvá María Moris Marianela Mego Fernando Salvador Anna Accarino Kathleen Ramírez Fernando Azpiroz Antonio Ruiz-de-Leon Israel Molina 2016-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004416 https://doaj.org/article/21d26fb53c8547329d873cde51165b63 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4744054?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004416 https://doaj.org/article/21d26fb53c8547329d873cde51165b63 PLoS Neglected Tropical Diseases, Vol 10, Iss 2, p e0004416 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004416 2022-12-31T12:07:08Z INTRODUCTION:Gastrointestinal involvement affects 30-40% of the patients with chronic Chagas disease. Esophageal symptoms appear once the structural damage is established. Little is known about the usefulness of high resolution manometry to early identification of esophageal involvement. METHOD:We performed a cross-sectional study at the Vall d'Hebron University Hospital (Barcelona, Spain) between May 2011 and April 2012. Consecutive patients diagnosed with Chagas disease in the chronic phase were offered to participate. All patients underwent a structured questionnaire about digestive symptoms, a barium esophagogram (Rezende classification) and an esophageal high resolution manometry (HRM). A control group of patients with heartburn who underwent an esophageal HRM in our hospital was selected. RESULTS:62 out of 73 patients that were included in the study fulfilled the study protocol. The median age of the Chagas disease group (CG) was 37 (IQR 32-45) years, and 42 (67.7%) patients were female. Twenty-seven (43.5%) patients had esophageal symptoms, heartburn being the most frequent. Esophagogram was abnormal in 5 (8.77%). The esophageal HRM in the CG showed a pathological motility pattern in 14 patients (22.6%). All of them had minor disorders of the peristalsis (13 with ineffective esophageal motility and 1 with fragmented peristalsis). Hypotonic lower esophageal sphincter was found more frequently in the CG than in the control group (21% vs 3.3%; p<0.01). Upper esophageal sphincter was hypertonic in 22 (35.5%) and hypotonic in 1 patient. When comparing specific manometric parameters or patterns in the CG according to the presence of symptoms or esophagogram no statistically significant association were seen, except for distal latency. CONCLUSION:The esophageal involvement measured by HRM in patients with chronic Chagas disease in our cohort is 22.6%. All the patients with esophageal alterations had minor disorders of the peristalsis. Symptoms and esophagogram results did not correlate with the HRM results. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 2 e0004416 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Adrián Sánchez-Montalvá María Moris Marianela Mego Fernando Salvador Anna Accarino Kathleen Ramírez Fernando Azpiroz Antonio Ruiz-de-Leon Israel Molina High Resolution Esophageal Manometry in Patients with Chagas Disease: A Cross-Sectional Evaluation. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
INTRODUCTION:Gastrointestinal involvement affects 30-40% of the patients with chronic Chagas disease. Esophageal symptoms appear once the structural damage is established. Little is known about the usefulness of high resolution manometry to early identification of esophageal involvement. METHOD:We performed a cross-sectional study at the Vall d'Hebron University Hospital (Barcelona, Spain) between May 2011 and April 2012. Consecutive patients diagnosed with Chagas disease in the chronic phase were offered to participate. All patients underwent a structured questionnaire about digestive symptoms, a barium esophagogram (Rezende classification) and an esophageal high resolution manometry (HRM). A control group of patients with heartburn who underwent an esophageal HRM in our hospital was selected. RESULTS:62 out of 73 patients that were included in the study fulfilled the study protocol. The median age of the Chagas disease group (CG) was 37 (IQR 32-45) years, and 42 (67.7%) patients were female. Twenty-seven (43.5%) patients had esophageal symptoms, heartburn being the most frequent. Esophagogram was abnormal in 5 (8.77%). The esophageal HRM in the CG showed a pathological motility pattern in 14 patients (22.6%). All of them had minor disorders of the peristalsis (13 with ineffective esophageal motility and 1 with fragmented peristalsis). Hypotonic lower esophageal sphincter was found more frequently in the CG than in the control group (21% vs 3.3%; p<0.01). Upper esophageal sphincter was hypertonic in 22 (35.5%) and hypotonic in 1 patient. When comparing specific manometric parameters or patterns in the CG according to the presence of symptoms or esophagogram no statistically significant association were seen, except for distal latency. CONCLUSION:The esophageal involvement measured by HRM in patients with chronic Chagas disease in our cohort is 22.6%. All the patients with esophageal alterations had minor disorders of the peristalsis. Symptoms and esophagogram results did not correlate with the HRM results. |
format |
Article in Journal/Newspaper |
author |
Adrián Sánchez-Montalvá María Moris Marianela Mego Fernando Salvador Anna Accarino Kathleen Ramírez Fernando Azpiroz Antonio Ruiz-de-Leon Israel Molina |
author_facet |
Adrián Sánchez-Montalvá María Moris Marianela Mego Fernando Salvador Anna Accarino Kathleen Ramírez Fernando Azpiroz Antonio Ruiz-de-Leon Israel Molina |
author_sort |
Adrián Sánchez-Montalvá |
title |
High Resolution Esophageal Manometry in Patients with Chagas Disease: A Cross-Sectional Evaluation. |
title_short |
High Resolution Esophageal Manometry in Patients with Chagas Disease: A Cross-Sectional Evaluation. |
title_full |
High Resolution Esophageal Manometry in Patients with Chagas Disease: A Cross-Sectional Evaluation. |
title_fullStr |
High Resolution Esophageal Manometry in Patients with Chagas Disease: A Cross-Sectional Evaluation. |
title_full_unstemmed |
High Resolution Esophageal Manometry in Patients with Chagas Disease: A Cross-Sectional Evaluation. |
title_sort |
high resolution esophageal manometry in patients with chagas disease: a cross-sectional evaluation. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004416 https://doaj.org/article/21d26fb53c8547329d873cde51165b63 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 2, p e0004416 (2016) |
op_relation |
http://europepmc.org/articles/PMC4744054?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004416 https://doaj.org/article/21d26fb53c8547329d873cde51165b63 |
op_doi |
https://doi.org/10.1371/journal.pntd.0004416 |
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PLOS Neglected Tropical Diseases |
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10 |
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2 |
container_start_page |
e0004416 |
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