Antimalarial Potential of Carica papaya and Vernonia amygdalina in Mice Infected with Plasmodium berghei
The study determined if administration of Vernonia amygdalina and Carica papaya plants provides synergistic effects in ameliorating plasmodium infection in mice. Thirty mice (17.88–25.3 g) were divided into 6 groups of 5 mice each. Group 1 was normal control, while groups 2–6 were intraperitoneally...
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ftdoajarticles:oai:doaj.org/article:21cbc2e339834ab580e3752a0e3c1d76 2023-05-15T15:08:53+02:00 Antimalarial Potential of Carica papaya and Vernonia amygdalina in Mice Infected with Plasmodium berghei Oche Okpe Nathan Habila Joseph Ikwebe Vincent A. Upev Stanley I. R. Okoduwa Omiagocho T. Isaac 2016-01-01T00:00:00Z https://doi.org/10.1155/2016/8738972 https://doaj.org/article/21cbc2e339834ab580e3752a0e3c1d76 EN eng Hindawi Limited http://dx.doi.org/10.1155/2016/8738972 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2016/8738972 https://doaj.org/article/21cbc2e339834ab580e3752a0e3c1d76 Journal of Tropical Medicine, Vol 2016 (2016) Arctic medicine. Tropical medicine RC955-962 article 2016 ftdoajarticles https://doi.org/10.1155/2016/8738972 2022-12-31T10:56:33Z The study determined if administration of Vernonia amygdalina and Carica papaya plants provides synergistic effects in ameliorating plasmodium infection in mice. Thirty mice (17.88–25.3 g) were divided into 6 groups of 5 mice each. Group 1 was normal control, while groups 2–6 were intraperitoneally inoculated 2.5 × 107 Plasmodium berghei parasitized red blood cell, followed by daily administration of 350 mg/kg aqueous leaf extracts after establishment of infection. Group 2 was disease control, while group 6 was treated with standard drug for four consecutive days. The results showed significant (P<0.05) reduction in percentage of parasite load between the infected treatment groups and disease control group at day 3 after infection, which remained consistent until the end of the experiment. All infected treated groups showed significant (P<0.05) increases in RBC and PCV recovery compared to the disease control, with the exception of WBC. There was insignificant (P>0.05) change in mean body weight of all treated groups except in disease control group. Histological studies of the infected mice indicate recovery of hepatic cells from congested black pigmentation. The reduction in parasite load and recovery of hepatic cell damage/hematological parameters were induced by these plant extracts. This highlighted the important usage of the plant in traditional remedy of malaria infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2016 1 6 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
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Arctic medicine. Tropical medicine RC955-962 Oche Okpe Nathan Habila Joseph Ikwebe Vincent A. Upev Stanley I. R. Okoduwa Omiagocho T. Isaac Antimalarial Potential of Carica papaya and Vernonia amygdalina in Mice Infected with Plasmodium berghei |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
The study determined if administration of Vernonia amygdalina and Carica papaya plants provides synergistic effects in ameliorating plasmodium infection in mice. Thirty mice (17.88–25.3 g) were divided into 6 groups of 5 mice each. Group 1 was normal control, while groups 2–6 were intraperitoneally inoculated 2.5 × 107 Plasmodium berghei parasitized red blood cell, followed by daily administration of 350 mg/kg aqueous leaf extracts after establishment of infection. Group 2 was disease control, while group 6 was treated with standard drug for four consecutive days. The results showed significant (P<0.05) reduction in percentage of parasite load between the infected treatment groups and disease control group at day 3 after infection, which remained consistent until the end of the experiment. All infected treated groups showed significant (P<0.05) increases in RBC and PCV recovery compared to the disease control, with the exception of WBC. There was insignificant (P>0.05) change in mean body weight of all treated groups except in disease control group. Histological studies of the infected mice indicate recovery of hepatic cells from congested black pigmentation. The reduction in parasite load and recovery of hepatic cell damage/hematological parameters were induced by these plant extracts. This highlighted the important usage of the plant in traditional remedy of malaria infection. |
format |
Article in Journal/Newspaper |
author |
Oche Okpe Nathan Habila Joseph Ikwebe Vincent A. Upev Stanley I. R. Okoduwa Omiagocho T. Isaac |
author_facet |
Oche Okpe Nathan Habila Joseph Ikwebe Vincent A. Upev Stanley I. R. Okoduwa Omiagocho T. Isaac |
author_sort |
Oche Okpe |
title |
Antimalarial Potential of Carica papaya and Vernonia amygdalina in Mice Infected with Plasmodium berghei |
title_short |
Antimalarial Potential of Carica papaya and Vernonia amygdalina in Mice Infected with Plasmodium berghei |
title_full |
Antimalarial Potential of Carica papaya and Vernonia amygdalina in Mice Infected with Plasmodium berghei |
title_fullStr |
Antimalarial Potential of Carica papaya and Vernonia amygdalina in Mice Infected with Plasmodium berghei |
title_full_unstemmed |
Antimalarial Potential of Carica papaya and Vernonia amygdalina in Mice Infected with Plasmodium berghei |
title_sort |
antimalarial potential of carica papaya and vernonia amygdalina in mice infected with plasmodium berghei |
publisher |
Hindawi Limited |
publishDate |
2016 |
url |
https://doi.org/10.1155/2016/8738972 https://doaj.org/article/21cbc2e339834ab580e3752a0e3c1d76 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2016 (2016) |
op_relation |
http://dx.doi.org/10.1155/2016/8738972 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2016/8738972 https://doaj.org/article/21cbc2e339834ab580e3752a0e3c1d76 |
op_doi |
https://doi.org/10.1155/2016/8738972 |
container_title |
Journal of Tropical Medicine |
container_volume |
2016 |
container_start_page |
1 |
op_container_end_page |
6 |
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1766340158353833984 |