Dioxin-like compounds are not associated with bone strength measured by ultrasonography in Inuit women from Nunavik (Canada): results of a cross-sectional study
Background. Bone strength in Inuit people appears lower than that of non-Aboriginals. Inuit are exposed to persistent organic pollutants including dioxin-like compounds (DLCs) through their traditional diet that comprises predatory fish and marine mammal fat. Results from experimental and population...
Published in: | International Journal of Circumpolar Health |
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2013
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ftdoajarticles:oai:doaj.org/article:21bdd45d26a94bc29784cf86194dc417 2023-05-15T15:12:23+02:00 Dioxin-like compounds are not associated with bone strength measured by ultrasonography in Inuit women from Nunavik (Canada): results of a cross-sectional study Alexandra-Cristina Paunescu Pierre Ayotte Éric Dewailly Sylvie Dodin 2013-05-01T00:00:00Z https://doi.org/10.3402/ijch.v72i0.20843 https://doaj.org/article/21bdd45d26a94bc29784cf86194dc417 EN eng Taylor & Francis Group http://www.circumpolarhealthjournal.net/index.php/ijch/article/download/20843/pdf_1 https://doaj.org/toc/2242-3982 doi:10.3402/ijch.v72i0.20843 2242-3982 https://doaj.org/article/21bdd45d26a94bc29784cf86194dc417 International Journal of Circumpolar Health, Vol 72, Iss 0, Pp 1-8 (2013) bone strength stiffness index dioxin-like compounds polychlorinated biphenyls Inuit women Arctic medicine. Tropical medicine RC955-962 article 2013 ftdoajarticles https://doi.org/10.3402/ijch.v72i0.20843 2022-12-31T11:47:37Z Background. Bone strength in Inuit people appears lower than that of non-Aboriginals. Inuit are exposed to persistent organic pollutants including dioxin-like compounds (DLCs) through their traditional diet that comprises predatory fish and marine mammal fat. Results from experimental and population studies suggest that some DLCs can alter bone metabolism and increase bone fragility. Objective. This cross-sectional descriptive study was conducted to examine the relationship between the stiffness index (SI) and plasma concentrations of total DLCs or specific dioxin-like polychlorinated biphenyls (DL-PCBs) in Inuit women of Nunavik (Northern Quebec, Canada). Methods. SI was determined by ultrasonography at the right calcaneus of 194 Inuit women aged 35–72 years who participated to Qanuippitaa? How Are We? Nunavik Inuit Health Survey in 2004. Plasma total DLC levels were quantified by measuring the aryl hydrocarbon receptor–mediated transcriptional activity elicited by plasma sample extracts in a cell-based reporter gene assay. Plasma concentrations of DL-PCBs nos. 105, 118, 156, 157, 167 and 189 were measured by gas chromatography–mass spectrometry. We used multiple linear regression analyses to investigate relations between total DLCs or specific DL-PCBs and SI, taking into consideration several potential confounders. Results. Neither total plasma DLCs nor specific DL-PCBs were associated with SI after adjustment for several confounders and covariates. Conclusion. Our results do not support a relation between exposure to DLCs and bone strength measured by ultrasonography in Inuit women of Nunavik. Article in Journal/Newspaper Arctic Circumpolar Health International Journal of Circumpolar Health inuit Nunavik Directory of Open Access Journals: DOAJ Articles Arctic Canada Nunavik International Journal of Circumpolar Health 72 1 20843 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
bone strength stiffness index dioxin-like compounds polychlorinated biphenyls Inuit women Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
bone strength stiffness index dioxin-like compounds polychlorinated biphenyls Inuit women Arctic medicine. Tropical medicine RC955-962 Alexandra-Cristina Paunescu Pierre Ayotte Éric Dewailly Sylvie Dodin Dioxin-like compounds are not associated with bone strength measured by ultrasonography in Inuit women from Nunavik (Canada): results of a cross-sectional study |
topic_facet |
bone strength stiffness index dioxin-like compounds polychlorinated biphenyls Inuit women Arctic medicine. Tropical medicine RC955-962 |
description |
Background. Bone strength in Inuit people appears lower than that of non-Aboriginals. Inuit are exposed to persistent organic pollutants including dioxin-like compounds (DLCs) through their traditional diet that comprises predatory fish and marine mammal fat. Results from experimental and population studies suggest that some DLCs can alter bone metabolism and increase bone fragility. Objective. This cross-sectional descriptive study was conducted to examine the relationship between the stiffness index (SI) and plasma concentrations of total DLCs or specific dioxin-like polychlorinated biphenyls (DL-PCBs) in Inuit women of Nunavik (Northern Quebec, Canada). Methods. SI was determined by ultrasonography at the right calcaneus of 194 Inuit women aged 35–72 years who participated to Qanuippitaa? How Are We? Nunavik Inuit Health Survey in 2004. Plasma total DLC levels were quantified by measuring the aryl hydrocarbon receptor–mediated transcriptional activity elicited by plasma sample extracts in a cell-based reporter gene assay. Plasma concentrations of DL-PCBs nos. 105, 118, 156, 157, 167 and 189 were measured by gas chromatography–mass spectrometry. We used multiple linear regression analyses to investigate relations between total DLCs or specific DL-PCBs and SI, taking into consideration several potential confounders. Results. Neither total plasma DLCs nor specific DL-PCBs were associated with SI after adjustment for several confounders and covariates. Conclusion. Our results do not support a relation between exposure to DLCs and bone strength measured by ultrasonography in Inuit women of Nunavik. |
format |
Article in Journal/Newspaper |
author |
Alexandra-Cristina Paunescu Pierre Ayotte Éric Dewailly Sylvie Dodin |
author_facet |
Alexandra-Cristina Paunescu Pierre Ayotte Éric Dewailly Sylvie Dodin |
author_sort |
Alexandra-Cristina Paunescu |
title |
Dioxin-like compounds are not associated with bone strength measured by ultrasonography in Inuit women from Nunavik (Canada): results of a cross-sectional study |
title_short |
Dioxin-like compounds are not associated with bone strength measured by ultrasonography in Inuit women from Nunavik (Canada): results of a cross-sectional study |
title_full |
Dioxin-like compounds are not associated with bone strength measured by ultrasonography in Inuit women from Nunavik (Canada): results of a cross-sectional study |
title_fullStr |
Dioxin-like compounds are not associated with bone strength measured by ultrasonography in Inuit women from Nunavik (Canada): results of a cross-sectional study |
title_full_unstemmed |
Dioxin-like compounds are not associated with bone strength measured by ultrasonography in Inuit women from Nunavik (Canada): results of a cross-sectional study |
title_sort |
dioxin-like compounds are not associated with bone strength measured by ultrasonography in inuit women from nunavik (canada): results of a cross-sectional study |
publisher |
Taylor & Francis Group |
publishDate |
2013 |
url |
https://doi.org/10.3402/ijch.v72i0.20843 https://doaj.org/article/21bdd45d26a94bc29784cf86194dc417 |
geographic |
Arctic Canada Nunavik |
geographic_facet |
Arctic Canada Nunavik |
genre |
Arctic Circumpolar Health International Journal of Circumpolar Health inuit Nunavik |
genre_facet |
Arctic Circumpolar Health International Journal of Circumpolar Health inuit Nunavik |
op_source |
International Journal of Circumpolar Health, Vol 72, Iss 0, Pp 1-8 (2013) |
op_relation |
http://www.circumpolarhealthjournal.net/index.php/ijch/article/download/20843/pdf_1 https://doaj.org/toc/2242-3982 doi:10.3402/ijch.v72i0.20843 2242-3982 https://doaj.org/article/21bdd45d26a94bc29784cf86194dc417 |
op_doi |
https://doi.org/10.3402/ijch.v72i0.20843 |
container_title |
International Journal of Circumpolar Health |
container_volume |
72 |
container_issue |
1 |
container_start_page |
20843 |
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1766343077910282240 |